Mutations at homologous positions to ABCC7 p.Ile106
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Ile106Cys
|
N
D
?
|
| ABCC8 |
p.Val324Met
|
D
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Leu101Cys
p.Leu101*
p.Leu102Pro
p.Leu102Cys
p.Leu102Arg
p.Gly103*
p.Gly103Cys
p.Gly103Glu
p.Arg104Cys
p.Arg104Glu
p.Arg104Gln
p.Ile105Asn
p.Ala107Val
p.Ala107Cys
p.Ser108Phe
p.Ser108Cys
p.Tyr109Cys
p.Tyr109Asn
p.Tyr109*
p.Asp110Tyr
p.Asp110His
p.Asp110Glu
p.Asp110Asn
p.Asp110Cys
p.Asp110Arg
p.Pro111Leu
p.Pro111Ala
|
N
D
?
-
-
D
D
N
D
?
D
D
?
-
-
?
D
D
?
D
D
?
D
D
?
D
N
?
N
N
?
D
D
N
N
?
N
N
?
N
N
N
D
?
D
D
D
D
D
-
-
D
N
D
N
D
D
N
D
N
D
D
D
D
D
N
D
N
D
D
N
|
| ABCC1 |
p.Lys347Asp
p.Lys347Leu
p.Lys351Asn
p.Val353Met
|
N
D
?
N
D
?
N
N
?
N
N
?
|
| ABCC8 |
p.His326Ala
p.Gly328Arg
|
N
D
?
N
N
?
|
The alignment around the queried position:
ABCC7 69
-
-
I
N
F
F
F
F
I
V
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
N
I
I
L
G
L
L
129
ABCC1 313
-
-
L
F
K
V
L
Y
T
F
G
F
L
M
S
F
F
F
A
I
L
M
M
F
S
G
Q
I
L
L
L
I
F
N
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
K
A
Q
G
Y
F
Y
T
V
L
F
V
372
ABCC2 308
S
W
L
M
K
L
F
T
F
Y
M
V
L
L
F
L
L
L
V
N
I
F
T
F
V
S
P
Q
L
L
K
L
L
I
S
F
A
S
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
T
Y
L
W
I
G
Y
L
A
I
L
L
T
369
ABCC3 299
-
-
F
L
K
A
L
L
A
F
S
S
F
L
I
S
A
C
F
K
L
I
Q
D
L
L
S
F
I
N
P
Q
L
L
S
I
L
I
R
F
I
S
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
P
M
A
P
W
W
G
F
L
V
A
G
L
M
F
L
358
ABCC4 78
S
L
T
R
A
I
I
K
C
Y
W
K
S
Y
L
V
L
G
I
F
T
L
I
E
E
S
A
K
V
I
Q
P
I
F
L
G
K
I
I
N
Y
F
E
N
Y
D
P
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
D
S
V
A
L
N
T
Y
A
Y
A
T
V
L
T
F
143
ABCC5 167
-
-
L
R
R
V
V
W
I
F
C
R
T
R
L
I
L
S
I
V
C
L
M
I
T
Q
L
A
G
F
S
G
P
A
F
M
V
K
H
L
L
E
Y
T
Q
A
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
E
S
N
L
Q
Y
S
L
L
L
V
L
G
L
L
L
227
ABCC6 299
-
-
L
L
K
A
I
W
Q
V
F
H
S
T
F
L
L
G
T
L
L
I
S
D
V
F
R
F
T
V
P
K
L
L
S
L
F
L
E
F
I
G
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
P
K
P
P
A
W
K
G
Y
L
L
A
V
M
F
L
358
ABCC8 285
I
Q
A
L
S
H
F
R
R
L
V
L
S
S
T
F
I
L
L
L
G
F
A
G
P
L
C
I
F
G
I
D
L
K
E
N
D
F
Q
P
Q
F
L
G
Y
F
V
S
S
Q
E
F
L
A
N
V
L
A
V
L
L
F
L
364
ABCC9 283
P
S
I
W
L
A
M
Y
R
A
F
G
R
P
I
L
L
S
S
T
F
R
Y
L
A
D
L
L
G
F
A
G
P
L
C
I
S
G
I
V
Q
R
V
N
E
T
Q
N
G
T
N
N
T
T
G
I
S
-
-
E
T
L
S
S
K
E
F
L
E
N
A
Y
V
L
A
V
L
L
F
L
360
ABCC10 273
-
-
L
W
R
A
L
Y
G
A
F
G
R
C
Y
L
A
L
G
L
L
K
L
V
G
T
M
L
G
F
S
G
P
L
L
L
S
L
L
V
G
F
L
E
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
Q
E
P
L
S
G
L
L
Y
A
L
G
L
A
G
332
ABCC11 151
-
-
V
L
L
V
M
L
R
F
Q
R
T
R
L
I
F
D
A
L
L
G
I
C
F
C
I
A
S
V
L
P
I
L
I
I
P
K
I
L
E
Y
S
E
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Q
L
G
N
V
V
H
G
V
G
L
C
F
A
L
F
L
211
ABCC12 111
-
-
L
S
H
V
V
W
K
F
Q
R
T
R
V
L
M
D
I
V
A
N
I
L
C
I
I
M
A
A
I
G
P
V
I
L
I
H
Q
I
L
Q
Q
T
E
R
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
S
G
K
V
W
V
G
I
G
L
C
I
A
L
F
A
171