Mutations at homologous positions to ABCB1 p.Ile160
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCB1 |
p.Ile160Thr
p.Val801Met
p.Val801Ser
|
D
D
?
N
N
?
D
D
?
|
ABCB4 |
p.Ile162Lys
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
ABCB1 |
p.Gln158Lys
p.Gln158Gly
p.Gly161Val
p.Phe163Cys
p.Asp164Ala
p.Asp164Cys
p.Asp164Gln
p.Leu797Ala
p.Asp800Asn
p.Asp800Ala
p.Ser802Ala
p.Ser802Thr
p.Trp803Ala
p.Trp803Cys
p.Trp803Phe
p.Trp803Leu
p.Trp803Ser
p.Trp803Tyr
p.Trp803Asp
p.Trp803Thr
p.Phe804Ala
p.Phe804Ser
p.Phe804Tyr
p.Phe804Leu
p.Phe804Trp
p.Phe804Cys
p.Phe804Gln
p.Phe804Asp
p.Asp805Cys
p.Asp805Asn
p.Asp805Ala
|
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
N
N
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
ABCB11 |
p.Ile182Lys
p.Met183Val
p.Met183Thr
p.Glu186Gly
p.Gly188Trp
|
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
|
ABCB4 |
p.Arg159*
p.Phe165Ile
p.Asp805Cys
p.Asp805Tyr
|
-
-
?
D
D
?
N
D
?
D
D
?
|
ABCB6 |
p.Leu356Pro
|
D
D
D
|
The alignment around the queried position:
ABCB1 124
G
L
V
V
-
-
-
F
R
Q
H
K
I
R
K
Q
F
F
H
I
M
R
E
W
-
-
V
H
D
G
E
N
T
R
S
K
I
E
198
ABCB1 765
-
-
-
L
T
K
L
R
M
V
R
S
M
R
Q
D
P
K
T
A
T
T
R
A
A
Q
V
K
G
841
ABCB2 297
A
S
A
V
L
E
F
V
G
D
G
-
-
-
I
Y
N
N
T
M
G
H
H
S
H
L
Q
G
E
V
F
G
A
V
L
R
Q
E
T
E
F
F
Q
-
-
Q
N
Q
T
G
N
I
M
S
R
V
T
E
D
T
T
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
371
ABCB3 202
G
S
S
L
S
A
G
R
G
G
-
-
-
F
T
Y
T
M
S
R
I
N
L
R
I
R
E
Q
L
F
S
S
L
L
R
Q
D
L
G
F
F
Q
-
-
E
T
K
T
G
E
L
N
R
L
S
S
D
T
L
M
S
N
W
L
N
A
N
V
L
S
L
V
276
ABCB4 126
V
L
V
A
A
Y
I
Q
S
-
-
-
F
T
L
A
A
G
I
R
K
I
Q
K
F
F
H
A
I
L
Q
E
G
W
D
-
-
I
N
D
T
T
E
L
N
R
L
T
D
D
I
S
K
I
S
E
I
G
D
K
V
G
M
F
F
Q
A
V
A
200
ABCB4 764
S
F
F
T
F
L
Q
F
-
-
-
F
G
K
A
G
E
I
L
T
R
R
L
S
M
A
F
K
A
M
L
R
Q
D
M
S
W
F
D
H
K
N
S
T
A
L
S
T
R
L
A
T
D
A
A
Q
V
Q
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
840
ABCB5 300
I
C
F
V
S
Y
F
M
Q
G
L
-
-
-
F
Y
G
R
A
G
E
I
L
T
M
R
L
R
H
L
A
F
K
A
M
L
Y
Q
D
I
A
W
F
D
E
K
E
N
S
T
G
L
T
T
I
L
A
I
D
I
A
Q
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
N
T
376
ABCB6 320
T
G
-
T
G
F
V
S
N
L
R
T
F
L
W
I
R
V
Q
Q
F
T
S
R
R
V
E
L
L
I
F
S
H
L
H
E
S
L
R
W
H
L
G
-
-
R
R
T
G
E
V
L
R
I
A
D
G
T
S
S
V
T
G
L
L
S
Y
L
V
F
N
V
I
P
T
L
A
396
ABCB7 199
S
R
A
G
A
A
F
F
N
V
R
N
A
V
F
G
K
V
A
Q
N
S
I
R
R
I
A
K
N
V
F
L
H
L
H
N
L
D
L
G
F
H
L
S
-
-
R
Q
T
G
A
L
S
K
A
I
D
R
G
T
R
G
I
S
F
V
L
S
A
L
V
F
N
L
L
P
I
M
F
276
ABCB8 201
L
Y
G
V
Q
G
L
L
T
F
G
Y
L
V
L
L
S
H
V
G
E
R
M
A
V
D
M
R
R
A
L
F
S
S
L
L
R
Q
D
I
T
F
F
D
-
-
A
N
K
T
G
Q
L
V
S
R
L
T
T
D
V
Q
E
F
K
S
S
F
K
L
V
I
S
Q
G
L
R
S
C
T
278
ABCB9 238
G
S
S
F
A
A
G
I
R
G
G
-
-
-
I
F
T
L
I
F
A
R
L
N
I
R
L
R
N
C
L
F
R
S
L
V
S
Q
E
T
S
F
F
D
-
-
E
N
R
T
G
D
L
I
S
R
L
T
S
D
T
T
M
V
S
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
V
312
ABCB10 224
C
G
A
A
A
N
A
I
R
V
Y
-
-
-
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
-
-
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
298
ABCB11 151
A
V
L
I
T
G
I
Q
I
C
-
-
-
F
W
V
I
A
A
R
Q
I
Q
K
M
R
K
F
Y
F
R
R
M
I
W
F
D
-
-
C
N
V
G
E
N
T
R
F
S
D
D
N
K
I
N
D
I
A
D
Q
A
L
F
I
Q
M
T
225
ABCB11 808
V
S
L
F
T
Q
F
L
Q
G
-
-
-
A
F
A
K
S
G
E
L
T
K
R
L
K
F
G
F
R
A
M
L
G
Q
D
I
A
W
F
D
D
L
R
N
S
P
A
L
T
R
L
A
T
D
S
Q
V
G
A
A
G
Q
I
M
I
V
N
S
F
T
884