ABCB4 p.Asp805Cys

Predicted by SNAP2: A: N (53%), C: N (61%), E: N (72%), F: D (53%), G: D (59%), H: N (61%), I: D (53%), K: N (53%), L: D (53%), M: N (72%), N: N (87%), P: D (71%), Q: N (72%), R: N (61%), S: N (61%), T: N (61%), V: N (53%), W: D (66%), Y: D (53%),
Predicted by PROVEAN: A: D, C: D, E: N, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

[switch to compact view]
Comments [show]
Publications
[hide] Kapoor K, Bhatnagar J, Chufan EE, Ambudkar SV
Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.
J Biol Chem. 2013 Nov 8;288(45):32622-36. doi: 10.1074/jbc.M113.498980. Epub 2013 Sep 24., [PMID:24064216]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Loo TW, Clarke DM
The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein.
J Biol Chem. 2015 Jul 3;290(27):16954-63. doi: 10.1074/jbc.M115.652602. Epub 2015 May 18., [PMID:25987565]

Abstract [show]
Comments [show]
Sentences [show]