Mutations at homologous positions to ABCC2 p.Ile448

Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 536
ABCC2 411
A
R
-
-
K
E
Y
T
V
G
E
T
V
N
L
M
S
V
D
A
Q
K
L
M
D
V
T
N
F
M
H
M
L
W
S
S
V
L
Q
I
V
L
S
I
F
F
L
W
R
E
L
G
P
S
V
L
A
G
V
G
V
M
V
L
V
I
P
I
N
A
I
L
S
T
K
S
K
T
I
Q
 488
ABCC1 414
A
R
-
-
K
S
S
T
V
G
E
I
V
N
L
M
S
V
D
A
Q
R
F
M
D
L
A
T
Y
I
N
M
I
W
S
A
P
L
Q
V
I
L
A
L
Y
L
L
W
L
N
L
G
P
S
V
L
A
G
V
A
V
M
V
L
M
V
P
V
N
A
V
M
A
M
K
T
K
T
Y
Q
 491
ABCC3 400
V
K
-
-
R
A
S
T
V
G
E
I
V
N
L
M
S
V
D
A
Q
R
F
M
D
L
A
P
F
L
N
L
L
W
S
A
P
L
Q
I
I
L
A
I
Y
F
L
W
Q
N
L
G
P
S
V
L
A
G
V
A
F
M
V
L
L
I
P
L
N
G
A
V
A
V
K
M
R
A
F
Q
 477
ABCC4 185
A
M
G
-
-
K
T
T
T
G
Q
I
V
N
L
L
S
N
D
V
N
K
F
D
Q
V
T
V
F
L
H
F
L
W
A
G
P
L
Q
A
I
A
V
T
A
L
L
W
M
E
I
G
I
S
C
L
A
G
M
A
V
L
I
I
L
L
P
L
Q
S
C
F
G
K
L
F
S
S
L
R
 262
ABCC5 269
K
E
-
-
-
-
K
S
L
G
E
L
I
N
I
C
S
N
D
G
Q
R
M
F
E
A
A
A
V
G
S
L
L
A
G
G
P
V
V
A
I
L
G
M
I
Y
N
V
I
I
L
G
P
T
G
F
L
G
S
A
V
F
I
L
F
Y
P
A
M
M
F
A
S
R
L
T
A
Y
F
R
 344
ABCC6 400
S
R
-
-
K
A
S
A
V
G
D
V
V
N
L
V
S
V
D
V
Q
R
L
T
E
S
V
L
Y
L
N
G
L
W
L
P
L
V
W
I
V
V
C
F
V
Y
L
W
Q
L
L
G
P
S
A
L
T
A
I
A
V
F
L
S
L
L
P
L
N
F
F
I
S
K
K
R
N
H
H
Q
 477
ABCC7 171
V
L
D
-
-
K
I
S
I
G
Q
L
V
S
L
L
S
N
N
L
N
K
F
D
E
G
L
A
L
A
H
F
V
W
I
A
P
L
Q
V
A
L
L
M
G
L
I
W
E
L
L
Q
A
S
A
F
C
G
L
G
F
L
I
V
L
A
L
F
Q
A
G
L
G
R
M
M
M
K
Y
R
 248
ABCC8 406
N
L
S
M
G
E
M
T
A
G
Q
I
C
N
L
V
A
I
D
T
N
Q
L
M
W
F
F
F
L
C
P
N
L
W
A
M
P
V
Q
I
I
V
G
V
I
L
L
Y
Y
I
L
G
V
S
A
L
I
G
A
A
V
I
I
L
L
A
P
V
Q
Y
F
V
A
T
K
L
S
Q
A
Q
 485
ABCC9 402
N
L
S
M
G
E
M
T
L
G
Q
I
N
N
L
V
A
I
E
T
N
Q
L
M
W
F
L
F
L
C
P
N
L
W
A
M
P
V
Q
I
I
M
G
V
I
L
L
Y
N
L
L
G
S
S
A
L
V
G
A
A
V
I
V
L
L
A
P
I
Q
Y
F
I
A
T
K
L
A
E
A
Q
 481
ABCC10 374
-
-
-
-
-
R
P
P
T
G
E
A
L
N
L
L
G
T
D
S
E
R
L
L
N
F
A
G
S
F
H
E
A
W
G
L
P
L
Q
L
A
I
T
L
Y
L
L
Y
Q
Q
V
G
V
A
F
V
G
G
L
I
L
A
L
L
L
V
P
V
N
K
V
I
A
T
R
I
M
A
S
N
 448
ABCC11 253
I
H
-
-
-
-
I
T
S
G
E
A
I
S
F
F
T
G
D
V
N
Y
L
F
E
G
V
C
Y
G
P
L
V
L
I
T
C
A
S
L
V
I
C
S
I
S
S
Y
F
I
I
G
Y
T
A
F
I
A
I
L
C
Y
L
L
V
F
P
L
A
V
F
M
T
R
M
A
V
K
A
Q
 328
ABCC12 213
T
H
-
-
-
-
I
S
V
G
E
V
L
N
I
L
S
S
D
S
Y
S
L
F
E
A
A
L
F
C
P
L
P
A
T
I
P
I
L
M
V
F
C
A
A
Y
A
F
F
I
L
G
P
T
A
L
I
G
I
S
V
Y
V
I
F
I
P
V
Q
M
F
M
A
K
L
N
S
A
F
R
 288