Mutations at homologous positions to ABCB3 p.Ala374
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB3 |
p.Ala374Asp
p.Ala374Thr
|
D
D
?
D
D
?
|
| ABCB1 |
p.Asn296Cys
p.Asn296Ala
p.Gly939Val
p.Gly939Cys
|
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCB11 |
p.Gly982Arg
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB3 |
p.Arg373Cys
p.Val379Ile
p.Val379Ala
|
D
D
?
N
N
N
N
N
?
|
| ABCB1 |
p.Ile293Cys
p.Thr294Cys
p.Thr294Ala
p.Ala295Cys
p.Ile297Cys
p.Ile297Arg
p.Ser298Cys
p.Ser298Ala
p.Ser298Arg
p.Ile299Met
p.Ile299Cys
p.Gly300Val
p.Ala301Thr
p.Ala301Val
p.Ala301Cys
p.Ala301Asp
p.Ala935Cys
p.His936Cys
p.Ile937Ser
p.Ile937Cys
p.Phe938Ala
p.Phe938Cys
p.Ile940Ser
p.Ile940Cys
p.Thr941Ala
p.Thr941Cys
p.Thr941Gly
p.Phe942Ala
p.Phe942Cys
p.Phe942Arg
p.Ser943Ala
p.Ser943Cys
p.Phe944Ala
p.Phe944Cys
|
N
D
?
D
D
?
N
N
?
N
D
?
N
D
?
D
D
?
N
D
?
N
N
?
D
D
?
N
N
?
N
N
?
D
D
?
N
N
?
N
N
?
N
N
?
D
N
?
D
D
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
N
D
?
N
D
?
N
N
?
N
N
?
N
D
?
D
D
?
D
D
?
D
D
?
N
N
?
N
D
?
D
D
?
N
D
?
|
| ABCB11 |
p.Gly327Glu
p.Asn979Asp
|
D
D
?
N
N
?
|
| ABCB2 |
p.Ala465Val
|
D
D
?
|
| ABCB4 |
p.Ile299Met
p.Ile299Cys
p.Met301Thr
p.Gly302Ala
p.Ala934Thr
p.Ile936Ala
p.Phe941Ser
|
N
N
?
N
D
?
N
D
?
D
D
?
D
D
?
N
D
?
D
D
?
|
The alignment around the queried position:
ABCB3 335
A
V
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
L
Y
L
L
R
V
L
H
L
G
V
Q
M
L
M
L
S
G
L
Q
Q
M
Q
D
-
G
E
L
T
Q
G
S
L
S
F
M
413
ABCB1 257
V
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
L
A
S
A
L
Y
G
L
V
S
-
Y
I
G
V
335
ABCB1 900
A
I
E
N
T
V
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
R
F
G
A
Y
L
V
A
H
-
K
L
M
S
F
E
D
V
V
978
ABCB2 430
A
L
S
A
M
P
T
V
R
S
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
G
G
Q
L
V
T
S
-
G
A
V
S
S
G
N
L
V
T
F
V
508
ABCB4 259
A
L
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
T
L
V
I
S
-
K
E
T
I
G
N
A
M
T
V
F
337
ABCB4 899
A
I
E
N
I
R
T
V
V
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
F
S
Y
C
F
F
G
A
Y
L
I
V
N
-
G
H
M
R
F
R
D
V
I
V
F
977
ABCB5 435
A
L
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
F
I
Y
F
A
Y
A
A
G
F
R
F
G
A
Y
L
I
Q
A
-
G
R
M
T
P
E
G
M
F
I
V
F
513
ABCB6 456
S
L
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
V
I
G
L
G
L
L
A
G
S
L
L
C
A
Y
F
V
T
E
-
Q
K
L
Q
V
G
D
Y
V
L
F
G
534
ABCB7 336
S
L
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
I
F
S
V
G
L
T
A
I
M
V
L
A
S
Q
G
V
A
-
G
T
L
T
V
G
D
L
M
V
N
414
ABCB8 337
A
L
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
A
F
N
C
M
V
L
G
T
L
F
I
G
G
S
L
V
A
G
-
Q
Q
L
T
G
G
D
L
M
S
F
L
415
ABCB9 371
T
I
S
A
M
K
T
V
R
S
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
T
L
L
V
V
Q
V
S
I
L
Y
Y
G
G
H
L
V
I
S
-
G
Q
M
T
S
G
N
L
I
A
F
I
449
ABCB10 357
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
-
A
H
M
T
V
G
E
L
S
S
F
L
435
ABCB11 284
I
S
S
M
R
T
A
A
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
L
I
F
L
A
A
F
Y
G
S
T
L
V
L
D
E
G
E
T
P
G
T
L
V
Q
I
F
363
ABCB11 943
A
L
S
N
I
T
V
A
G
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
I
M
F
I
A
N
S
A
S
Y
R
Y
Y
I
S
-
E
G
L
H
F
S
Y
V
F
R
V
I
1021