Mutations at homologous positions to ABCB1 p.Arg580
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Arg580Cys
|
D
D
?
|
| ABCB11 |
p.Arg1268Gln
|
D
D
?
|
| ABCB4 |
p.Arg582Gln
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ala576Gly
p.Lys578Cys
p.Thr581Cys
p.Thr581Glu
p.Glu1223Asp
p.Thr1226Cys
p.Cys1227Ser
|
D
D
?
N
D
?
D
D
?
D
D
?
N
N
?
D
D
?
N
D
?
|
| ABCB2 |
p.Pro749Thr
|
N
N
?
|
| ABCB3 |
p.Arg651Cys
p.Arg651Trp
p.Thr655Ala
p.Val656Leu
p.Val656Ala
|
N
N
?
D
N
?
D
D
?
N
N
?
N
D
?
|
| ABCB4 |
p.Gly581Ala
p.Ile585Val
|
D
D
?
N
N
?
|
The alignment around the queried position:
894ABCB1 543
L
V
N
K
I
L
A
S
A
L
D
T
E
A
V
Q
V
A
L
D
K
-
-
R
G
T
I
V
I
A
H
L
S
V
N
D
V
I
G
D
G
V
I
V
E
K
G
N
H
E
L
M
K
E
-
K
619
ABCB1 1188
R
A
L
V
R
Q
L
L
L
A
S
A
L
D
T
E
S
K
V
E
A
L
D
K
-
-
A
R
G
R
I
V
I
A
H
R
L
S
I
Q
N
A
D
L
I
V
V
F
Q
N
R
K
E
H
G
H
Q
Q
A
Q
-
1264
ABCB2 715
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
E
R
Y
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
L
M
E
K
-
K
793
ABCB3 619
R
A
L
V
R
D
P
R
V
L
I
L
D
A
T
S
A
L
D
V
-
-
-
-
Q
E
Q
A
L
Q
D
W
N
S
G
D
R
L
V
I
A
L
Q
V
Q
R
A
H
Q
I
L
V
L
Q
-
-
-
-
-
-
E
G
K
L
Q
K
L
A
Q
L
-
-
687
ABCB4 545
L
V
N
P
K
I
L
L
D
A
T
S
A
L
T
E
S
E
A
E
V
Q
A
A
L
D
K
-
-
A
R
E
T
T
V
I
H
S
V
N
A
D
I
A
F
D
G
V
I
V
E
Q
G
S
H
S
L
M
K
K
-
E
621
ABCB4 1194
R
A
L
I
R
Q
P
Q
I
L
L
L
D
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
-
-
A
R
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
F
Q
N
G
R
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
-
K
1270
ABCB5 723
R
A
L
L
Q
K
P
K
I
L
L
L
D
E
A
T
S
A
L
D
N
D
S
E
K
V
V
Q
H
A
L
D
K
-
-
A
R
T
G
R
T
C
L
V
V
T
H
R
L
S
A
I
Q
N
A
D
L
I
V
V
L
H
N
G
K
I
K
E
Q
G
T
H
Q
E
L
L
R
N
-
R
799
ABCB6 739
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
-
-
V
C
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
S
R
-
G
815
ABCB7 621
R
A
I
L
K
D
P
P
V
I
L
Y
D
E
A
T
S
S
L
D
S
I
T
E
E
T
I
L
G
A
M
K
D
-
-
V
V
K
H
R
T
S
I
F
I
A
H
R
L
S
T
V
V
D
A
D
E
I
I
V
L
D
Q
G
K
V
A
E
R
G
T
H
H
G
L
L
A
N
P
H
698
ABCB8 624
R
A
L
I
K
Q
P
T
V
L
I
L
D
E
A
T
S
A
L
D
A
E
S
E
R
V
V
Q
E
A
L
D
R
-
-
A
S
A
G
R
T
V
L
V
I
A
H
R
L
S
T
V
R
G
A
H
C
I
V
V
M
A
D
G
R
V
W
E
A
G
T
H
E
E
L
L
K
K
-
G
700
ABCB9 655
R
A
L
V
N
P
P
V
L
I
L
D
E
A
T
S
A
L
D
A
E
S
E
Y
L
I
Q
Q
A
I
H
G
-
-
N
L
Q
K
H
T
V
L
I
I
A
R
L
S
T
V
E
H
A
H
L
I
V
V
L
D
K
G
R
V
V
Q
Q
G
T
H
Q
Q
L
L
A
Q
-
G
731
ABCB10 646
R
A
L
L
K
N
P
K
I
L
L
L
D
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
-
-
L
M
D
G
R
T
V
L
V
I
A
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
723
ABCB11 571
R
A
L
I
P
K
I
L
L
D
M
A
L
D
E
A
M
Q
E
V
L
S
K
-
-
I
Q
H
G
H
T
I
I
S
V
A
H
L
S
V
R
A
A
D
T
I
G
F
E
H
G
T
A
V
R
G
T
H
E
E
L
L
E
R
-
K
647
ABCB11 1231
A
I
V
D
P
K
I
L
L
E
A
T
S
A
D
T
E
S
E
K
T
V
Q
V
A
L
D
K
-
-
A
R
E
G
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
D
I
I
A
V
M
A
Q
V
V
I
E
K
T
H
E
L
M
A
Q
-
K
1307