Mutations at homologous positions to ABCC7 p.His484
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.His484Tyr
p.His484Arg
|
D
N
D
N
?
|
| ABCC2 |
p.Gly699Ala
|
D
D
?
|
| ABCC3 |
p.Gly689Ala
|
D
D
?
|
| ABCC9 |
p.Asn733Asp
|
N
N
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Glu479*
p.Gly480Cys
p.Gly480Ser
p.Gly480Asp
p.Lys481Glu
p.Ser485Cys
p.Ser485Arg
p.Arg487Gln
p.Arg487Ala
p.Arg487Ser
p.Ser489*
|
-
-
N
D
D
D
D
D
D
D
N
?
N
D
N
N
?
D
N
?
D
N
?
D
N
?
-
-
D
|
| ABCC4 |
p.Tyr477Trp
|
D
D
?
|
| ABCC8 |
p.Trp739Cys
|
D
D
?
|
| ABCC9 |
p.Val729Phe
p.Val734Ile
|
D
D
?
N
N
|
The alignment around the queried position:
894ABCC7 446
-
I
E
R
L
L
G
L
I
M
G
E
E
P
S
I
K
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
I
498
ABCC1 667
S
I
E
A
L
A
V
V
G
Q
G
S
L
L
S
A
L
L
A
E
M
K
V
E
G
H
V
A
I
K
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
V
A
Y
V
P
Q
A
W
I
Q
N
720
ABCC2 660
D
I
M
A
G
Q
L
V
A
V
G
P
V
G
S
S
S
L
I
S
A
M
L
G
E
M
E
N
V
H
G
H
I
T
I
K
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
T
A
Y
V
P
Q
Q
S
I
Q
N
G
713
ABCC3 650
Q
V
P
K
G
A
L
V
A
V
V
G
P
V
G
C
G
K
S
S
L
V
S
A
L
L
E
M
E
K
L
E
G
K
V
H
M
K
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
V
A
Y
V
P
Q
Q
A
W
I
Q
N
C
703
ABCC4 434
T
V
R
P
G
E
L
L
A
V
V
P
V
G
A
G
K
S
S
L
L
S
A
V
L
G
E
L
A
P
S
H
G
L
V
S
V
H
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
R
I
A
V
S
Q
Q
P
W
V
F
S
487
ABCC5 584
E
I
Q
E
G
K
L
V
G
I
C
S
V
G
S
G
K
T
S
L
I
S
A
I
L
G
Q
M
T
L
L
E
G
S
I
A
I
S
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
F
A
Y
V
A
Q
Q
A
W
I
L
N
A
637
ABCC6 652
T
V
P
G
C
L
L
A
V
V
V
A
G
K
S
S
L
S
A
L
G
E
L
S
K
V
E
G
F
V
S
I
E
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
V
A
Y
V
P
A
W
V
Q
N
T
705
ABCC8 702
R
I
P
R
G
Q
L
T
M
I
V
G
Q
G
S
S
L
L
L
A
L
G
E
M
Q
K
V
G
A
V
F
S
S
L
P
D
S
E
G
E
D
P
S
P
E
R
E
T
A
T
D
L
D
I
R
K
R
G
P
V
A
Y
A
S
K
P
W
L
L
N
A
781
ABCC9 694
R
I
P
T
G
Q
L
T
M
I
V
G
Q
V
G
C
G
S
S
L
L
L
A
I
L
G
E
M
Q
T
L
E
G
K
H
W
S
N
E
S
-
-
-
-
E
P
S
F
E
A
T
R
S
-
-
-
-
-
R
N
R
Y
S
V
A
Y
A
A
Q
K
P
W
L
L
N
A
764
ABCC10 622
E
V
K
K
G
M
L
V
G
I
V
G
K
V
G
C
G
K
S
S
L
L
A
A
I
A
G
E
L
H
R
L
R
G
H
V
A
V
R
G
L
S
K
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
F
G
L
A
T
Q
E
P
W
I
Q
F
A
678
ABCC11 533
V
V
S
K
G
M
M
L
G
V
C
G
N
T
G
S
G
K
S
S
L
L
S
A
I
L
E
E
M
H
L
L
E
G
S
V
G
V
Q
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
L
A
Y
V
P
Q
Q
A
W
I
V
S
G
586
ABCC12 502
V
V
R
K
G
K
I
L
G
I
C
G
N
V
G
S
G
K
S
S
L
L
A
A
L
L
G
Q
M
Q
L
Q
K
G
V
V
A
V
N
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
L
A
Y
V
S
Q
Q
A
W
I
F
H
G
555