Mutations at homologous positions to ABCB7 p.Leu144
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB7 |
p.Leu144Ala
|
N
D
?
|
| ABCB1 |
p.Val715Cys
p.Val715Ala
|
N
N
?
N
N
?
|
| ABCB4 |
p.Asp87Glu
p.Thr715Ile
|
N
N
?
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB7 |
p.Gly149Ala
|
N
D
?
|
| ABCB1 |
p.Thr76Ala
p.Ala80Glu
p.Ala80Gly
p.Ala80Pro
p.Ala80Cys
p.Ala80Arg
p.Tyr710Ala
p.Phe711Cys
p.Val712Cys
p.Val713Cys
p.Gly714Cys
p.Gly714Ala
p.Phe716Cys
p.Phe716Ala
p.Cys717Ser
p.Ala718Cys
p.Ala718Leu
p.Ile719Cys
p.Ile719Ala
p.Ile720Cys
|
N
D
?
D
N
?
N
N
?
D
N
?
N
N
?
N
N
?
D
D
?
N
D
?
N
D
?
N
D
?
D
D
?
D
D
?
N
D
?
N
N
?
N
D
?
N
D
?
D
D
?
N
D
?
N
N
?
N
D
?
|
| ABCB11 |
p.Glu96*
p.Gly758Arg
|
-
-
?
D
D
?
|
| ABCB2 |
p.Leu247Val
|
N
N
?
|
| ABCB4 |
p.Thr82Asn
p.Phe711Ser
|
D
D
?
N
D
?
|
The alignment around the queried position:
ABCB7 120
I
I
K
A
M
L
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Y
V
W
P
K
D
R
P
D
L
R
A
R
V
A
I
S
G
F
L
G
A
K
A
M
N
I
V
V
P
F
M
F
K
Y
A
V
D
S
L
N
Q
M
S
G
N
M
L
N
L
S
D
A
P
N
T
184
ABCB1 68
G
E
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
I
F
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
G
N
L
E
D
L
S
I
T
R
S
D
I
D
T
-
-
-
-
-
-
-
M
N
L
109
ABCB1 693
P
P
V
F
W
R
I
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
L
T
I
F
S
K
I
G
V
F
T
I
P
-
-
-
-
-
E
T
K
R
Q
750
ABCB2 232
-
-
-
P
V
R
R
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
C
L
G
S
E
T
R
R
S
L
F
L
V
L
V
V
L
S
S
L
G
E
M
A
I
P
F
F
T
G
R
L
T
D
W
I
L
-
-
-
-
-
-
-
-
-
D
G
S
A
D
282
ABCB3 134
N
K
V
L
M
W
R
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
R
P
D
L
P
L
L
V
A
A
F
F
F
L
V
L
A
V
L
G
T
L
I
P
H
Y
S
G
V
I
I
G
-
-
-
-
-
-
-
-
-
D
F
D
P
H
187
ABCB4 74
M
M
I
V
F
G
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
K
F
V
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
A
G
N
F
S
F
V
N
F
S
-
L
S
L
L
N
P
G
-
-
-
-
-
-
-
-
-
-
K
I
L
E
E
111
ABCB4 693
P
P
V
S
F
L
K
V
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
K
T
E
W
P
Y
V
V
G
V
C
A
I
A
N
G
L
A
S
V
I
S
E
I
I
F
G
D
D
-
-
-
-
-
-
A
V
K
Q
Q
749
ABCB5 229
P
E
V
S
L
L
K
I
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
K
P
E
W
P
F
V
V
L
G
T
L
A
S
V
L
N
G
T
V
H
P
V
F
S
I
I
F
A
K
I
I
T
M
F
G
N
N
D
K
-
-
-
-
-
-
T
T
L
K
H
285
ABCB6 230
V
R
S
A
A
Q
Q
S
T
W
R
D
F
G
R
K
L
R
L
L
S
G
Y
L
W
P
R
G
S
P
A
L
Q
L
V
V
L
I
C
L
G
L
M
G
L
E
A
L
N
V
L
V
P
I
F
Y
R
N
I
V
N
L
L
T
E
K
A
P
-
-
-
-
W
N
S
L
A
W
T
305
ABCB8 131
R
-
F
N
W
K
L
F
W
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Q
F
L
H
P
H
L
L
V
L
G
V
A
V
V
L
A
L
G
A
A
L
V
N
V
Q
I
P
L
L
L
G
Q
L
V
E
V
V
A
K
Y
T
R
-
-
-
-
-
-
D
H
V
G
S
186
ABCB9 171
G
-
A
T
L
Q
K
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
Y
T
K
P
D
V
A
F
L
V
A
A
S
F
F
L
I
V
A
A
L
G
E
T
F
L
P
Y
Y
T
G
R
A
I
D
G
I
V
I
-
-
-
-
-
-
-
-
-
Q
K
S
M
D
223
ABCB10 153
G
L
P
E
A
R
K
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-
-
-
-
-
-
V
D
Y
S
D
209
ABCB11 79
V
L
L
I
F
G
T
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
V
F
I
D
Y
D
V
L
Q
E
L
Q
I
P
G
K
A
V
N
N
T
V
T
N
S
S
L
N
N
T
N
G
T
C
G
L
-
-
-
-
-
L
N
I
S
136
ABCB11 737
E
P
A
P
V
R
R
I
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
F
S
A
P
E
W
P
Y
M
L
V
S
V
G
A
A
V
N
T
V
T
P
L
A
F
L
F
S
Q
I
L
G
T
F
S
I
P
D
K
-
-
-
-
-
-
E
E
R
S
793