ABCB2 p.Leu247Val
| Predicted by SNAP2: | A: D (53%), C: N (66%), D: D (75%), E: D (75%), F: N (87%), G: D (71%), H: D (71%), I: N (82%), K: D (75%), M: N (78%), N: D (75%), P: D (80%), Q: D (66%), R: D (75%), S: D (63%), T: D (63%), V: N (82%), W: D (66%), Y: D (59%), |
| Predicted by PROVEAN: | A: N, C: N, D: N, E: N, F: N, G: D, H: N, I: N, K: D, M: N, N: N, P: D, Q: N, R: D, S: N, T: N, V: N, W: N, Y: N, |
[switch to compact view]
Comments [show]
None has been submitted yet.
[hide] Nonclassical behavior of the mouse CD1 class I-lik... J Immunol. 1997 Mar 1;158(5):2143-9. Teitell M, Holcombe HR, Brossay L, Hagenbaugh A, Jackson MJ, Pond L, Balk SP, Terhorst C, Peterson PA, Kronenberg M
Nonclassical behavior of the mouse CD1 class I-like molecule.
J Immunol. 1997 Mar 1;158(5):2143-9., [PMID:9036959]
Abstract [show]
The mouse CD1 (mCD1) molecule is a class I-like molecule that is encoded outside of the MHC. We show here that mCD1 shares several properties with Ag-presenting class I molecules, including a requirement for beta2-microglobulin for stable cell-surface expression in T lymphocyte transfectants and thymocytes. mCD1 is also capable of binding to mouse CD8alphabeta heterodimers participating in the activation of CD8+ T cells in a manner similar to classical class I molecules. However, mCD1 surface expression is not decreased at high temperatures in cells that lack the transporter associated with Ag processing (TAP), including both RMA-S and Drosophila melanogaster cells. The data indicate that mCD1 does not require TAP to be expressed in a stable fashion at the cell surface. We speculate that the ability of mCD1 to reach the cell surface in transporter-deficient cells may reflect its ability to present a distinct set of ligands. The properties of mCD1 described here can account, in part, for the selection of the diverse populations of T cells that are known to be mCD1 reactive.
Comments [show]
None has been submitted yet.
No. Sentence Comment
140 mCDl is identical to this consensus CD8-binding sequencefor only 4 of the 11 positions, and it has a conserved amino acid change (leucine for valine at position 247) in a fifth position.
X
ABCB2 p.Leu247Val 9036959:140:130
status: NEW