Mutations at homologous positions to ABCB4 p.Asp87
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB4 |
p.Asp87Glu
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB4 |
p.Thr82Asn
p.Leu701Pro
p.Phe711Ser
|
D
D
?
D
D
?
N
D
?
|
| ABCB1 |
p.Thr76Ala
p.Ala80Glu
p.Ala80Gly
p.Ala80Pro
p.Ala80Cys
p.Ala80Arg
p.Glu707Ala
p.Trp708Arg
p.Pro709Gly
p.Pro709Ala
p.Tyr710Ala
p.Phe711Cys
|
N
D
?
D
N
?
N
N
?
D
N
?
N
N
?
N
N
?
D
D
?
D
D
?
N
D
?
N
D
?
D
D
?
N
D
?
|
| ABCB11 |
p.Thr87Arg
p.Glu96*
|
D
D
?
-
-
?
|
| ABCB2 |
p.Leu247Val
|
N
N
?
|
| ABCB3 |
p.Ser145Ala
|
N
N
?
|
The alignment around the queried position:
ABCB4 65
I
A
H
S
P
M
M
I
V
F
G
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
K
F
V
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
A
G
N
F
S
F
V
N
F
S
-
L
S
L
L
N
P
G
-
-
-
-
-
-
107
ABCB1 59
G
E
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
I
F
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
G
N
L
E
D
L
S
I
T
R
S
D
I
D
T
-
-
-
105
ABCB1 685
K
-
E
A
L
D
E
S
I
P
P
V
F
W
R
I
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
L
T
I
F
S
K
I
G
V
F
T
I
P
-
746
ABCB2 223
P
G
G
Q
G
G
S
G
N
-
-
-
P
V
R
R
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
C
L
G
S
E
T
R
R
S
L
F
L
V
L
V
V
L
S
S
L
G
E
M
A
I
P
F
F
T
G
R
L
T
D
W
I
L
-
-
-
-
-
278
ABCB3 125
Q
E
K
E
Q
D
Q
V
N
N
K
V
L
M
W
R
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
R
P
D
L
P
L
L
V
A
A
F
F
F
L
V
L
A
V
L
G
T
L
I
P
H
Y
S
G
V
I
I
G
-
-
-
-
-
183
ABCB4 684
E
T
D
G
L
E
A
N
V
P
P
V
S
F
L
K
V
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
K
T
E
W
P
Y
V
V
G
V
C
A
I
A
N
G
L
A
S
V
I
S
E
I
I
F
G
D
D
-
-
745
ABCB5 220
S
T
Q
S
K
E
I
S
L
P
E
V
S
L
L
K
I
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
L
N
K
P
E
W
P
F
V
V
L
G
T
L
A
S
V
L
N
G
T
V
H
P
V
F
S
I
I
F
A
K
I
I
T
M
F
G
N
N
D
K
-
-
281
ABCB6 221
E
D
Q
D
V
E
R
S
Q
V
R
S
A
A
Q
Q
S
T
W
R
D
F
G
R
K
L
R
L
L
S
G
Y
L
W
P
R
G
S
P
A
L
Q
L
V
V
L
I
C
L
G
L
M
G
L
E
A
L
N
V
L
V
P
I
F
Y
R
N
I
V
N
L
L
T
E
K
A
P
-
-
299
ABCB7 111
G
L
K
D
V
D
T
R
K
I
I
K
A
M
L
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Y
V
W
P
K
D
R
P
D
L
R
A
R
V
A
I
S
G
F
L
G
A
K
A
M
N
I
V
V
P
F
M
F
K
Y
A
V
D
S
L
N
Q
M
S
G
N
M
175
ABCB8 122
S
S
T
P
H
V
V
G
S
R
-
F
N
W
K
L
F
W
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Q
F
L
H
P
H
L
L
V
L
G
V
A
V
V
L
A
L
G
A
A
L
V
N
V
Q
I
P
L
L
L
G
Q
L
V
E
V
V
A
K
Y
T
R
-
-
182
ABCB9 162
G
R
P
P
P
E
Q
A
S
G
-
A
T
L
Q
K
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
Y
T
K
P
D
V
A
F
L
V
A
A
S
F
F
L
I
V
A
A
L
G
E
T
F
L
P
Y
Y
T
G
R
A
I
D
G
I
V
I
-
-
-
-
-
219
ABCB10 144
K
G
R
L
R
P
A
A
G
L
P
E
A
R
K
L
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-
-
205
ABCB11 70
F
H
G
I
A
Q
P
G
V
L
L
I
F
G
T
M
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
V
F
I
D
Y
D
V
L
Q
E
L
Q
I
P
G
K
A
V
N
N
T
V
T
N
S
S
L
N
N
T
N
G
T
C
G
L
-
132
ABCB11 728
K
D
I
V
Q
E
E
V
E
P
A
P
V
R
R
I
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
K
F
S
A
P
E
W
P
Y
M
L
V
S
V
G
A
A
V
N
T
V
T
P
L
A
F
L
F
S
Q
I
L
G
T
F
S
I
P
D
K
-
-
789