Mutations at homologous positions to ABCC8 p.Gly70
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Gly70Glu
p.Gly70Ala
p.Gly70Arg
|
D
D
?
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC8 |
p.Pro69Arg
p.Pro69Leu
p.Asn72Ser
p.Asn72Ala
p.Arg74Trp
p.Arg74*
p.Arg74Lys
p.Arg74Asp
p.Arg74Ala
p.Arg74Tyr
p.Arg74Glu
p.Arg74Gln
|
D
D
?
N
D
?
N
N
?
N
D
?
D
D
?
-
-
?
N
N
?
D
D
?
N
D
?
D
D
?
N
D
?
N
D
?
|
| ABCC1 |
p.Pro69Ala
p.Asn71Gln
p.Thr73Ile
p.Thr75Ala
|
N
N
?
N
D
?
D
N
?
N
N
?
|
| ABCC11 |
p.Arg19His
|
D
N
?
|
| ABCC3 |
p.His68Tyr
|
N
N
?
|
| ABCC5 |
p.Glu22Gln
|
N
N
?
|
| ABCC7 |
p.Met1Val
p.Arg3Trp
p.Pro5Leu
|
N
N
D
D
D
?
D
D
D
|
| ABCC9 |
p.His69Arg
|
D
D
?
|
The alignment around the queried position:
ABCC8 32
N
V
V
F
L
L
F
I
T
F
I
L
W
G
S
S
S
K
V
H
H
H
S
T
W
L
H
F
-
H
L
W
I
L
T
F
M
L
L
F
L
C
E
L
S
G
V
S
H
H
L
L
Y
M
P
-
110
ABCC1 31
F
Q
T
V
L
V
V
F
Y
L
A
F
Y
F
L
Y
L
S
R
H
R
G
Y
I
Q
M
T
L
K
K
A
L
G
F
L
I
V
A
L
F
Y
E
R
R
G
I
F
A
F
L
S
-
110
ABCC2 25
L
C
F
Q
T
V
L
V
W
I
P
L
G
L
W
L
L
A
P
W
Q
L
L
H
V
Y
K
S
R
T
K
R
S
S
T
T
K
L
Y
L
A
K
Q
V
F
V
G
F
L
L
I
L
A
I
E
L
A
L
V
L
T
E
D
S
-
G
Q
A
T
V
P
A
V
Y
T
-
103
ABCC3 30
P
C
F
Q
N
S
L
L
A
W
V
P
C
I
Y
L
W
V
A
L
P
C
Y
L
L
Y
L
R
H
H
C
R
G
Y
I
I
L
S
L
S
K
L
K
M
V
L
G
V
L
L
W
C
V
S
W
A
D
L
F
Y
S
F
H
G
L
V
H
G
A
P
A
P
F
F
V
T
-
109
ABCC4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC5 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
K
D
I
D
I
G
K
E
Y
I
I
P
S
P
G
Y
R
S
V
R
R
T
S
T
S
G
T
H
R
D
R
E
D
S
K
F
R
R
T
R
L
E
C
Q
D
A
L
E
T
A
A
R
A
-
57
ABCC6 29
L
C
F
L
R
T
A
G
V
V
P
M
Y
L
W
V
L
G
P
I
Y
L
L
F
I
H
H
H
G
R
L
R
M
S
P
L
F
K
A
K
M
V
L
G
F
A
L
I
V
L
C
T
S
S
V
A
V
A
L
W
K
I
Q
Q
G
T
P
E
A
P
E
F
L
I
H
-
108
ABCC7 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC9 30
N
L
V
P
H
V
F
L
L
I
T
F
P
I
L
F
I
G
W
G
S
S
S
K
V
Q
I
H
N
T
W
L
H
F
P
-
G
N
L
R
W
I
L
T
F
A
L
L
F
V
H
V
C
E
I
A
E
G
I
V
S
D
S
R
R
E
S
R
H
L
H
L
F
M
P
-
108
ABCC10 27
H
C
F
T
Q
L
V
L
S
A
L
P
H
A
L
L
A
V
L
S
A
C
Y
L
G
T
P
R
S
P
D
-
Y
I
L
P
C
S
P
G
W
R
L
R
L
A
A
S
F
L
L
S
V
F
P
L
L
D
L
L
P
V
A
L
P
P
G
A
G
P
G
P
I
G
L
E
V
L
A
G
105
ABCC11 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
T
R
K
R
T
Y
W
V
P
N
S
S
G
G
L
V
N
G
I
D
I
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
D
M
V
S
G
L
I
Y
K
T
Y
T
L
Q
-
40
ABCC12 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
V
G
-
-
-
-
-
-
-
-
-
-
-
4