ABCMdb

ABCC3 p.Pro450Arg

Predicted by SNAP2:	A: N (66%), C: D (59%), D: D (66%), E: D (71%), F: D (66%), G: D (59%), H: D (59%), I: N (53%), K: D (66%), L: D (59%), M: D (53%), N: D (63%), Q: D (63%), R: D (71%), S: D (53%), T: D (63%), V: N (78%), W: N (53%), Y: D (53%),
Predicted by PROVEAN:	A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

[switch to compact view]
Comments [show]

None has been submitted yet.

Publications
[hide] P-glycoprotein: so many ways to turn it on. J Clin Pharmacol. 2008 Mar;48(3):365-78. Epub 2007 Dec 21. Callaghan R, Crowley E, Potter S, Kerr ID
P-glycoprotein: so many ways to turn it on.
J Clin Pharmacol. 2008 Mar;48(3):365-78. Epub 2007 Dec 21., [PMID:18156365]

Abstract [show]
Expression of the ABC transporter P-glycoprotein (P-gp or ABCB1) is associated with resistance to chemotherapy in cancer. However, early investigations into the regulation of ABCB1 expression revealed that the process is not a classical induction as observed for certain metabolizing enzymes. The process involves the cellular stress response pathway initiated by either inflicted (e.g., chemotherapy damage) or endogenous (e.g., hypoxia) factors. However, ABCB1 is also expressed in a number of noncancerous tissues. In particular, the protein is found at tissues providing a barrier or secretory function. The localization of ABCB1 in normal tissues will impact significantly on drug pharmacokinetics, in particular the absorption and elimination processes. This review also describes the mechanism underlying ABCB1 expression in noncancerous tissue, a process that does not involve the stress response.

Comments [show]

None has been submitted yet.

Sentences [show]
No. Sentence Comment
174 In the same study, one such compound, the anti-neoplastic ET-743, EXPRESSION OF P-GLYCOPROTEIN REVIEW/DRUG METABOLISM AND TRANSPORT 373 CAR CYP2B ABCC1-C3 PXR CYP3A ABCC1-C2 ABCB1 AhR CYP1A GST UDP-GT GST UDP-GT FXR LXR CYP7A ABCB11 ABCC2 GST UDP-GT P450R GST UDP-GT P450R GST UDP-GT P450R GST UDP-GT P450R ABCA1 ABCG1 ABCG5 ABCG8 Figure 4. Login to comment