ABCMdb

Mutations at homologous positions to ABCC8 p.Ile747

Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27

Mutations exactly at the same position:

		SNAP2 PROVEAN Effect_dbs
ABCC8	p.Ile747Val details	N N ?
ABCC2	p.Gly699Ala details	D D ?
ABCC3	p.Gly689Ala details	D D ?

Mutations +/- 5 a.a. around the position:

ABCC4	p.Tyr477Trp details	D D ?
ABCC7	p.Lys481Glu details p.His484Tyr details p.His484Arg details p.Ser485Cys details p.Ser485Arg details p.Arg487Gln details p.Arg487Ala details p.Arg487Ser details p.Ser489* details p.Phe490Leu details p.Cys491Ser details p.Cys491Arg details p.Cys491Ala details p.Cys491Phe details p.Cys491Val details	D N ? D N D N ? N D N N ? D N ? D N ? D N ? - - D D D ? N N ? D N N N ? D N ? N N ?
ABCC9	p.Asn733Asp details p.Val734Ile details	N N N N

The alignment around the queried position:

900
ABCC8 708

L

T

M

I

V

G

Q

G

S

S

L

L

L

A

L

G

E

M

Q

K

V

G

A

V

F

S

S

L

P

D

S

E

G

E

D

P

S

P

E

R

E

T

A

T

D

L

D

I

R

K

R

G

P

V

A

Y

A

S

K

P

W

L

L

N

A

T

V

E

E

N

I

787
ABCC1 673

L

A

V

V

G

Q

G

S

L

L

S

A

L

L

A

E

M

K

V

E

G

H

V

A

I

K

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

S

V

A

Y

V

P

Q

A

W

I

Q

N

S

L

E

N

I

726
ABCC2 666

L

V

A

V

G

P

V

G

S

S

S

L

I

S

A

M

L

G

E

M

E

N

V

H

G

H

I

T

I

K

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

T

T

A

Y

V

P

Q

Q

S

I

Q

N

G

T

I

K

D

I

719
ABCC3 656

L

V

A

V

V

G

P

V

G

C

G

K

S

S

L

V

S

A

L

L

E

M

E

K

L

E

G

K

V

H

M

K

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

S

V

A

Y

V

P

Q

Q

A

W

I

Q

N

C

T

L

Q

E

N

V

709
ABCC4 440

L

L

A

V

V

P

V

G

A

G

K

S

S

L

L

S

A

V

L

G

E

L

A

P

S

H

G

L

V

S

V

H

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

R

I

A

V

S

Q

Q

P

W

V

F

S

T

L

R

S

N

I

493
ABCC5 590

L

V

G

I

C

S

V

G

S

G

K

T

S

L

I

S

A

I

L

G

Q

M

T

L

L

E

G

S

I

A

I

S

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

T

F

A

Y

V

A

Q

Q

A

W

I

L

N

A

T

L

R

D

N

I

643
ABCC6 658

L

L

A

V

V

V

A

G

K

S

S

L

S

A

L

G

E

L

S

K

V

E

G

F

V

S

I

E

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

A

V

A

Y

V

P

A

W

V

Q

N

T

S

V

V

E

N

V

711
ABCC7 451

L

L

G

L

I

M

G

E

E

P

S

I

K

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

I

I

G

K

504
ABCC9 700

L

T

M

I

V

G

Q

V

G

C

G

S

S

L

L

L

A

I

L

G

E

M

Q

T

L

E

G

K

H

W

S

N

E

S

-

-

-

-

E

P

S

F

E

A

T

R

S

-

-

-

-

-

R

N

R

Y

S

V

A

Y

A

A

Q

K

P

W

L

L

N

A

T

V

E

E

N

I

770
ABCC10 628

L

V

G

I

V

G

K

V

G

C

G

K

S

S

L

L

A

A

I

A

G

E

L

H

R

L

R

G

H

V

A

V

R

G

L

S

K

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

F

G

L

A

T

Q

E

P

W

I

Q

F

A

T

I

R

D

N

I

684
ABCC11 539

M

L

G

V

C

G

N

T

G

S

G

K

S

S

L

L

S

A

I

L

E

E

M

H

L

L

E

G

S

V

G

V

Q

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

S

L

A

Y

V

P

Q

Q

A

W

I

V

S

G

N

I

R

E

N

I

592
ABCC12 508

I

L

G

I

C

G

N

V

G

S

G

K

S

S

L

L

A

A

L

L

G

Q

M

Q

L

Q

K

G

V

V

A

V

N

G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

T

L

A

Y

V

S

Q

Q

A

W

I

F

H

G

N

V

R

E

N

I

561