Mutations at homologous positions to ABCC8 p.Leu3
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Leu3Pro
|
N
N
?
|
| ABCC1 |
p.Leu3Arg
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC8 |
p.Met1Ala
p.Ala4Val
p.Cys6Ser
|
N
N
?
N
N
?
D
D
?
|
| ABCC1 |
p.Gly5Glu
p.Cys7Ala
|
N
N
?
D
D
?
|
| ABCC7 |
p.Met1Val
p.Arg3Trp
p.Pro5Leu
|
N
N
D
D
D
?
D
D
D
|
The alignment around the queried position:
ABCC8 1
P
F
G
S
E
A
A
Y
R
V
Q
L
G
V
D
N
V
V
F
L
L
F
I
T
43
ABCC1 1
M
A
R
F
-
S
A
D
S
D
L
W
D
W
T
W
S
N
P
D
F
T
F
Q
T
V
L
V
V
42
ABCC2 1
-
M
L
E
K
F
C
N
S
T
F
W
N
S
S
F
L
D
S
-
-
-
-
-
-
E
A
D
P
L
C
F
Q
T
V
L
V
W
I
P
36
ABCC3 1
-
-
M
D
A
L
C
G
S
G
E
L
S
F
W
D
N
L
S
V
H
T
E
N
P
D
L
T
P
C
F
Q
N
S
L
L
A
W
V
P
41
ABCC4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC5 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC6 1
-
-
M
A
A
P
A
E
P
C
A
G
Q
G
-
V
W
Q
T
E
P
E
P
A
A
T
S
L
L
S
L
C
F
L
R
T
A
G
V
V
40
ABCC7 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC9 1
M
S
L
S
F
C
G
-
-
N
N
I
S
Y
N
I
N
D
G
V
L
Q
N
S
F
V
D
A
L
N
L
V
P
H
V
F
L
L
I
T
41
ABCC10 1
-
-
M
E
R
L
L
A
Q
L
C
G
S
S
A
A
W
P
P
-
-
-
L
W
E
G
D
T
T
G
H
C
F
T
Q
L
V
L
S
A
L
P
38
ABCC11 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC12 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1