Mutations at homologous positions to ABCC6 p.Leu1063
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC6 |
p.Leu1063Arg
|
D
D
D
|
| ABCC7 |
p.Ile991Val
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC6 |
p.Arg1064Trp
|
D
D
D
|
| ABCC1 |
p.Pro1088Ala
p.Glu1089Gln
p.Glu1089Asp
p.Glu1089Ala
p.Glu1089Asn
p.Glu1089Leu
p.Glu1089Lys
p.Lys1092Arg
p.Lys1092Met
p.Lys1092Glu
p.Lys1092Ala
|
N
D
?
D
N
?
D
N
?
D
N
?
D
N
?
D
N
?
D
N
?
N
N
?
D
N
?
D
N
?
D
D
?
|
| ABCC2 |
p.Arg1100His
p.Arg1100Cys
p.Arg1100Ala
|
D
D
?
D
D
?
D
D
?
|
| ABCC7 |
p.Asp993Arg
p.Asp993Tyr
p.Asp993Gly
p.Asp993Cys
p.Phe994Cys
|
D
N
?
D
D
D
N
?
D
D
?
N
D
?
|
| ABCC8 |
p.Cys1141Ser
|
N
N
?
|
| ABCC9 |
p.Arg1116Cys
p.Arg1116His
|
D
D
D
D
D
D
|
The alignment around the queried position:
ABCC6 1024
L
W
D
V
V
S
P
I
S
F
F
E
R
T
P
I
H
L
L
N
R
F
K
E
T
D
T
V
V
D
I
P
D
K
S
L
L
M
Y
A
F
G
L
L
E
V
S
L
V
V
A
V
A
T
P
L
A
T
V
A
I
L
P
L
F
L
L
Y
A
G
F
Q
S
1103
ABCC1 1052
L
L
H
S
I
L
S
M
S
F
F
E
T
S
G
N
L
V
N
R
F
S
K
E
L
D
V
M
I
V
I
M
F
M
G
L
F
V
I
G
A
I
V
I
L
L
A
T
I
A
A
I
I
I
L
G
L
I
Y
F
F
V
Q
1131
ABCC2 1060
L
L
N
I
L
A
M
R
F
F
D
T
T
P
T
G
R
I
V
N
R
F
A
G
D
I
S
T
V
D
D
T
L
P
Q
S
L
S
W
I
T
C
F
G
I
I
S
T
L
V
M
I
C
M
T
P
V
F
T
I
I
V
I
P
L
G
I
I
Y
V
S
V
Q
M
1139
ABCC3 1048
L
L
H
N
K
I
R
S
P
Q
S
F
F
D
T
T
P
S
G
R
I
L
N
C
F
S
K
D
I
Y
V
V
D
E
V
L
A
P
V
I
L
M
L
L
N
S
F
F
N
A
I
S
T
L
V
V
I
M
A
S
T
P
L
F
T
V
V
I
L
P
L
A
V
L
Y
T
L
V
Q
R
1127
ABCC4 801
F
E
S
I
L
K
A
P
V
L
F
F
D
N
P
I
G
I
L
N
R
F
S
K
D
I
G
H
L
D
D
L
L
P
L
T
F
L
D
F
I
Q
T
L
L
Q
V
V
G
V
S
V
A
V
A
V
I
P
W
I
A
P
L
V
P
L
G
I
I
F
I
F
L
R
R
880
ABCC5 951
L
F
R
R
I
L
R
S
P
M
K
F
F
D
T
T
P
T
G
R
I
L
N
R
F
S
K
D
M
D
E
V
D
V
R
L
P
F
Q
A
E
M
F
I
Q
N
V
I
L
V
F
F
C
V
G
M
I
A
G
V
F
P
W
F
L
V
A
V
G
P
L
V
I
L
F
S
V
L
H
I
1030
ABCC7 952
L
P
T
L
N
K
A
G
I
N
F
A
I
L
D
L
L
P
L
T
F
I
Q
L
L
I
V
I
G
A
V
V
L
Q
I
V
A
T
V
V
F
L
A
1031
ABCC8 1100
L
L
N
R
I
I
L
A
P
M
R
F
F
E
T
T
P
L
G
S
I
L
R
F
S
S
D
N
I
D
Q
H
I
P
S
T
L
E
L
S
R
S
T
C
V
S
A
L
A
V
I
S
Y
V
T
P
V
F
L
V
L
L
P
L
A
I
V
Y
F
I
K
1179
ABCC9 1072
L
L
N
I
I
L
G
P
I
R
F
F
D
T
T
P
L
G
L
I
L
N
R
F
S
A
D
T
N
I
I
D
Q
H
I
P
P
T
L
E
S
L
T
S
T
L
L
C
L
S
A
I
G
I
S
Y
A
T
P
V
F
L
V
A
L
L
P
L
G
V
A
F
Y
F
I
Q
K
1151
ABCC10 1004
L
L
H
R
V
L
M
A
P
V
T
F
F
N
A
T
P
T
G
R
I
L
N
R
F
S
S
D
V
A
C
A
D
D
S
L
P
F
I
L
N
I
L
L
A
N
A
G
L
L
G
L
L
A
V
L
G
S
G
L
P
W
L
L
L
L
L
P
P
L
S
I
M
Y
Y
H
V
Q
R
1083
ABCC11 899
L
F
N
K
V
F
R
C
P
M
S
F
F
D
T
I
P
I
G
R
L
L
N
C
F
A
G
D
L
E
Q
L
D
Q
L
L
P
I
F
S
E
Q
F
L
V
L
S
L
M
V
I
A
V
L
L
I
V
S
V
L
S
P
Y
I
L
L
M
G
A
I
I
M
V
I
C
F
I
Y
Y
M
978
ABCC12 888
V
F
D
K
I
L
K
S
P
M
S
F
F
D
T
T
P
T
G
R
L
M
N
R
F
S
K
D
M
D
E
L
D
V
R
L
P
F
H
A
E
N
F
L
Q
Q
F
F
M
V
V
F
I
L
V
I
L
A
A
V
F
P
A
V
L
L
V
V
A
S
L
A
V
G
F
F
I
L
L
R
967