Mutations at homologous positions to ABCB11 p.Glu186

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 455
ABCB11 150
V
A
V
L
I
T
G
Y
I
Q
I
C
-
-
-
F
W
V
I
A
A
A
R
Q
I
Q
K
M
R
K
F
Y
F
R
R
I
M
R
M
E
I
G
W
F
D
-
-
C
N
S
V
G
E
L
N
T
R
F
S
D
D
I
N
K
I
N
D
A
I
A
D
Q
M
A
L
F
I
Q
R
M
 224
ABCB1 123
A
G
V
L
V
A
A
Y
I
Q
V
S
-
-
-
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
K
Q
F
F
H
A
I
M
R
Q
E
I
G
W
F
D
-
-
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
S
M
 197
ABCB1 764
I
I
S
F
I
T
F
F
L
Q
G
F
-
-
-
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
R
S
M
L
R
Q
D
V
S
W
F
D
D
P
K
N
T
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
I
G
S
R
L
A
V
I
T
Q
N
I
 840
ABCB2 296
I
A
S
A
V
L
E
F
V
G
D
G
-
-
-
I
Y
N
N
T
M
G
H
V
H
S
H
L
Q
G
E
V
F
G
A
V
L
R
Q
E
T
E
F
F
Q
-
-
Q
N
Q
T
G
N
I
M
S
R
V
T
E
D
T
S
T
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
 370
ABCB3 201
F
G
S
S
L
S
A
G
C
R
G
G
-
-
-
C
F
T
Y
T
M
S
R
I
N
L
R
I
R
E
Q
L
F
S
S
L
L
R
Q
D
L
G
F
F
Q
-
-
E
T
K
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
 275
ABCB4 125
A
G
V
L
V
A
A
Y
I
Q
V
S
-
-
-
F
W
T
L
A
A
G
R
Q
I
R
K
I
R
Q
K
F
F
H
A
I
L
R
Q
E
I
G
W
F
D
-
-
I
N
D
T
T
E
L
N
T
R
L
T
D
D
I
S
K
I
S
E
G
I
G
D
K
V
G
M
F
F
Q
A
V
 199
ABCB4 763
I
I
S
F
F
T
F
F
L
Q
G
F
-
-
-
T
F
G
K
A
G
E
I
L
T
R
R
L
R
S
M
A
F
K
A
M
L
R
Q
D
M
S
W
F
D
D
H
K
N
S
T
G
A
L
S
T
R
L
A
T
D
A
A
Q
V
Q
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
 839
ABCB5 299
V
I
C
F
V
S
Y
F
M
Q
G
L
-
-
-
F
Y
G
R
A
G
E
I
L
T
M
R
L
R
H
L
A
F
K
A
M
L
Y
Q
D
I
A
W
F
D
E
K
E
N
S
T
G
G
L
T
T
I
L
A
I
D
I
A
Q
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
N
A
 375
ABCB6 319
G
T
G
S
-
T
G
F
V
S
N
L
R
T
F
L
W
I
R
V
Q
Q
F
T
S
R
R
V
E
L
L
I
F
S
H
L
H
E
L
S
L
R
W
H
L
G
-
-
R
R
T
G
E
V
L
R
I
A
D
R
G
T
S
S
V
T
G
L
L
S
Y
L
V
F
N
V
I
P
T
L
 395
ABCB7 198
V
S
R
A
G
A
A
F
F
N
E
V
R
N
A
V
F
G
K
V
A
Q
N
S
I
R
R
I
A
K
N
V
F
L
H
L
H
N
L
D
L
G
F
H
L
S
-
-
R
Q
T
G
A
L
S
K
A
I
D
R
G
T
R
G
I
S
F
V
L
S
A
L
V
F
N
L
L
P
I
M
 275
ABCB8 200
I
L
Y
G
V
Q
G
L
L
T
F
G
Y
L
V
L
L
S
H
V
G
E
R
M
A
V
D
M
R
R
A
L
F
S
S
L
L
R
Q
D
I
T
F
F
D
-
-
A
N
K
T
G
Q
L
V
S
R
L
T
T
D
V
Q
E
F
K
S
S
F
K
L
V
I
S
Q
G
L
R
S
C
 277
ABCB9 237
I
G
S
S
F
A
A
G
I
R
G
G
-
-
-
I
F
T
L
I
F
A
R
L
N
I
R
L
R
N
C
L
F
R
S
L
V
S
Q
E
T
S
F
F
D
-
-
E
N
R
T
G
D
L
I
S
R
L
T
S
D
T
T
M
V
S
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
 311
ABCB10 223
L
C
G
A
A
A
N
A
I
R
V
Y
-
-
-
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
-
-
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
 297
ABCB11 807
C
V
S
L
F
T
Q
F
L
Q
G
Y
-
-
-
A
F
A
K
S
G
E
L
L
T
K
R
L
R
K
F
G
F
R
A
M
L
G
Q
D
I
A
W
F
D
D
L
R
N
S
P
G
A
L
T
T
R
L
A
T
D
A
S
Q
V
Q
G
A
A
G
S
Q
I
G
M
I
V
N
S
F
 883