Mutations at homologous positions to ABCB1 p.Ile306
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Ile306Cys
p.Ile306Glu
p.Ile306Arg
p.Ile306Ala
p.Met949Ala
p.Met949Cys
p.Met949Arg
|
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCB4 |
p.Met948Ile
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ala301Thr
p.Ala301Val
p.Ala301Cys
p.Ala301Asp
p.Ala302Cys
p.Ala302Arg
p.Phe303Cys
p.Phe303Arg
p.Leu304Cys
p.Tyr307Cys
p.Tyr307Phe
p.Tyr307Arg
p.Tyr310Phe
p.Phe944Ala
p.Phe944Cys
p.Thr945Ala
p.Thr945Cys
p.Thr945Arg
p.Thr945Glu
p.Gln946Ala
p.Gln946Cys
p.Gln946Arg
p.Ala947Leu
p.Ala947Cys
p.Ala947Val
p.Met948Ala
p.Met948Ile
p.Tyr950Ala
p.Tyr950Cys
p.Tyr950Phe
p.Tyr950Arg
p.Phe951Ala
p.Ser952Ala
p.Ser952Arg
p.Tyr953Ala
p.Tyr953Cys
p.Tyr953Phe
p.Tyr953Arg
p.Ala954Leu
p.Ala954Cys
|
N
N
?
N
N
?
N
N
?
D
N
?
N
N
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
N
N
?
D
D
?
N
D
?
D
D
?
N
D
?
N
N
?
D
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
D
D
?
N
D
?
N
N
?
D
D
?
D
D
?
N
N
?
D
D
?
N
D
?
N
N
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
N
D
?
|
| ABCB11 |
p.Trp330*
p.Trp330Arg
p.Cys336Ser
p.Tyr337His
|
-
-
?
D
D
?
N
N
?
D
D
?
|
| ABCB3 |
p.Val379Ile
p.Val379Ala
p.Arg380Gln
|
N
N
N
N
N
?
D
N
?
|
| ABCB4 |
p.Gln945*
p.Ala946Thr
p.Phe947Ala
p.Tyr949Ala
p.Tyr949Phe
p.Tyr949Gln
p.Ala953Asp
|
-
-
?
N
D
?
N
N
?
D
D
?
N
N
?
D
D
?
D
D
?
|
The alignment around the queried position:
ABCB1 267
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
L
A
S
A
L
Y
G
L
V
S
-
Y
I
G
V
345
ABCB1 910
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
R
F
G
A
Y
L
V
A
H
-
K
L
M
S
F
E
D
V
V
988
ABCB2 440
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
G
G
Q
L
V
T
S
-
G
A
V
S
S
G
N
L
V
T
F
V
L
Y
Q
M
Q
F
T
Q
A
518
ABCB3 345
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
L
Y
L
L
R
V
L
H
L
G
V
Q
M
L
M
L
S
G
L
Q
Q
M
Q
D
-
G
E
L
T
Q
G
S
L
S
F
M
I
Y
Q
E
S
V
G
S
Y
V
423
ABCB4 269
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
T
L
V
I
S
-
K
E
T
I
G
N
A
M
T
V
F
F
S
I
L
I
G
A
F
V
347
ABCB4 909
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
F
S
Y
C
F
F
G
A
Y
L
I
V
N
-
G
H
M
R
F
R
D
V
I
V
F
A
I
V
F
A
V
A
L
987
ABCB5 445
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
F
I
Y
F
A
Y
A
A
G
F
R
F
G
A
Y
L
I
Q
A
-
G
R
M
T
P
E
G
M
F
I
V
F
T
A
I
A
Y
G
A
A
I
523
ABCB6 466
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
V
I
G
L
G
L
L
A
G
S
L
L
C
A
Y
F
V
T
E
-
Q
K
L
Q
V
G
D
Y
V
L
F
G
T
Y
I
I
Q
L
Y
M
P
L
544
ABCB7 346
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
I
F
S
V
G
L
T
A
I
M
V
L
A
S
Q
G
V
A
-
G
T
L
T
V
G
D
L
M
V
N
G
L
L
F
Q
L
S
L
P
L
424
ABCB8 347
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
A
F
N
C
M
V
L
G
T
L
F
I
G
G
S
L
V
A
G
-
Q
Q
L
T
G
G
D
L
M
S
F
L
V
A
S
Q
T
V
Q
R
S
M
425
ABCB9 381
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
T
L
L
V
V
Q
V
S
I
L
Y
Y
G
G
H
L
V
I
S
-
G
Q
M
T
S
G
N
L
I
A
F
I
I
Y
E
F
V
L
G
D
C
M
459
ABCB10 367
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
-
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
445
ABCB11 294
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
L
I
F
L
A
A
F
Y
G
S
T
L
V
L
D
E
G
E
T
P
G
T
L
V
Q
I
F
L
S
V
I
V
G
A
L
N
L
373
ABCB11 953
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
I
M
F
I
A
N
S
A
S
Y
R
Y
Y
I
S
-
E
G
L
H
F
S
Y
V
F
R
V
I
S
A
V
V
L
S
A
A
L
1031