Mutations at homologous positions to ABCC7 p.Ala534
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Ala534Glu
p.Ala534Pro
p.Ala534Gln
|
N
N
D
N
N
?
N
N
?
|
| ABCC1 |
p.Gly756Asp
p.Gly756Ser
|
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Asp529Phe
p.Asp529Asn
p.Ile530Leu
p.Ser531Pro
p.Ser531Thr
p.Lys532Glu
p.Phe533Leu
p.Lys536*
p.Lys536Gln
p.Asp537Asn
p.Asp537Glu
p.Asp537Phe
p.Ile539Thr
|
D
D
?
D
D
?
N
N
N
N
?
N
N
?
N
N
?
N
N
-
-
N
N
?
D
D
?
D
D
D
D
?
N
N
?
|
| ABCC3 |
p.Thr742Cys
|
D
D
?
|
| ABCC6 |
p.Ile742Val
|
N
N
D
|
| ABCC8 |
p.Leu814Ala
p.Pro815Ala
p.Asp818Ala
p.Asp818Gly
p.Asp818Val
|
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
The alignment around the queried position:
970ABCC7 495
I
G
K
G
D
E
K
A
E
N
V
G
I
S
574
ABCC1 717
I
Q
N
S
L
E
N
I
L
G
Q
L
E
E
P
Y
Y
R
S
V
I
Q
A
A
L
L
P
D
L
E
I
L
P
S
D
R
T
E
I
G
E
K
G
V
N
S
G
Q
K
Q
R
V
S
L
A
R
A
Y
S
N
A
D
I
Y
L
F
L
S
796
ABCC2 710
I
Q
N
G
T
I
K
D
I
L
F
T
E
F
N
E
K
R
Y
Q
Q
V
L
E
A
C
A
L
P
D
L
E
M
L
P
G
G
D
L
A
E
I
G
E
G
I
N
L
S
G
G
Q
K
Q
I
S
L
A
R
A
T
Y
Q
N
L
D
I
Y
L
L
D
P
L
789
ABCC3 700
I
Q
N
C
T
L
Q
E
N
V
L
F
G
K
A
L
N
P
R
Y
Q
Q
T
L
E
A
C
A
L
L
A
D
L
E
M
L
P
G
G
D
Q
E
I
G
E
K
G
I
N
L
S
G
G
Q
R
Q
R
V
S
L
A
R
A
Y
S
D
A
I
F
L
L
D
D
P
L
S
779
ABCC4 484
V
F
S
T
L
R
S
N
I
L
F
G
K
Y
E
K
E
R
Y
E
K
V
I
K
A
C
A
L
K
K
D
L
Q
L
L
E
D
G
D
L
T
V
I
G
D
G
T
T
L
S
G
Q
K
A
R
V
N
L
A
R
V
Y
Q
D
A
D
I
L
D
D
P
L
S
563
ABCC5 634
I
L
N
A
T
L
R
D
N
I
L
F
G
K
E
Y
D
E
E
R
Y
N
S
V
L
N
S
C
C
L
R
P
D
L
A
I
L
P
S
S
D
L
T
E
I
G
E
R
G
A
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
L
Y
S
D
R
S
I
Y
I
L
D
D
P
L
S
713
ABCC6 702
V
Q
N
T
S
V
V
E
N
V
C
F
G
Q
E
L
P
P
W
L
E
V
E
A
C
A
L
Q
P
D
V
D
S
F
P
E
G
H
T
S
I
G
E
G
N
L
S
G
Q
K
Q
L
S
L
A
V
K
A
A
V
Y
L
L
D
P
L
781
ABCC8 778
L
L
N
A
T
V
E
E
N
I
I
F
E
S
P
F
N
K
Q
R
Y
K
M
V
I
E
A
S
L
P
D
I
D
I
H
G
Q
T
Q
I
G
E
G
I
N
L
G
G
Q
Q
I
S
V
A
A
L
Y
Q
H
A
N
V
V
F
L
P
F
S
857
ABCC9 761
L
L
N
A
T
V
E
E
N
I
T
F
G
S
P
F
N
K
Q
R
Y
K
A
V
T
D
A
C
S
L
Q
P
D
I
D
L
L
P
F
G
D
Q
T
E
I
G
E
R
G
I
N
L
S
G
G
Q
R
Q
R
I
C
V
A
R
A
L
Y
Q
N
T
N
I
V
F
L
D
D
P
F
S
840
ABCC10 675
I
Q
F
A
T
I
R
D
N
I
L
F
G
K
T
F
D
A
Q
L
Y
K
E
V
L
E
A
C
A
L
N
D
D
L
S
I
L
P
A
G
D
Q
T
E
V
G
E
K
G
V
T
L
S
G
G
Q
R
A
R
I
A
L
A
R
A
V
Y
Q
E
K
E
L
Y
L
L
D
D
P
L
A
754
ABCC11 583
I
V
S
G
N
I
R
E
N
I
L
M
G
G
A
Y
D
K
A
R
Y
L
Q
V
L
H
C
C
S
L
N
R
D
L
E
L
L
P
F
G
D
M
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
K
Q
R
I
S
L
A
R
A
V
Y
S
D
R
Q
I
Y
L
L
D
D
P
L
S
662
ABCC12 552
I
F
H
G
N
V
R
E
N
I
L
F
G
E
K
Y
D
H
Q
R
Y
Q
H
T
V
R
V
C
G
L
Q
K
D
L
S
N
L
P
Y
G
D
L
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
V
Y
S
D
R
Q
L
Y
L
L
D
D
P
L
S
631