Mutations at homologous positions to ABCC7 p.Cys76
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Cys76Ser
p.Cys76Trp
p.Cys76Arg
|
D
D
?
D
D
?
D
D
?
|
| ABCC3 |
p.Thr306Ile
|
D
D
?
|
| ABCC8 |
p.Ala294Thr
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Ala72Asp
p.Leu73Phe
p.Arg74Trp
p.Arg74Gln
p.Arg75Gln
p.Arg75*
p.Arg75Glu
p.Arg75Leu
p.Trp79*
p.Trp79Arg
p.Arg80Glu
|
D
D
D
D
?
D
N
D
D
N
D
N
-
-
D
D
D
D
D
D
-
-
N
D
D
N
?
|
| ABCC1 |
p.Lys319Asp
p.Pro323Ala
p.Tyr324Ala
p.Tyr324Trp
p.Tyr324Phe
|
D
D
?
N
D
?
D
D
?
N
D
?
N
N
?
|
| ABCC2 |
p.Ala313Gly
p.Lys316Ala
|
D
D
?
N
D
?
|
| ABCC3 |
p.Gly308Val
|
D
D
?
|
| ABCC8 |
p.Gly296Arg
|
N
D
D
|
The alignment around the queried position:
ABCC7 69
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
N
F
F
F
F
I
V
L
-
-
-
-
113
ABCC1 291
V
D
A
N
E
E
V
A
V
K
S
P
Q
K
E
W
N
P
S
-
-
-
-
-
-
-
-
-
-
L
F
K
V
L
Y
T
F
G
F
L
M
S
F
F
F
A
I
L
M
M
F
S
G
Q
I
L
L
L
I
F
N
D
-
-
-
-
-
356
ABCC2 278
K
N
Q
Q
D
A
L
E
D
V
E
K
K
K
K
K
S
G
T
K
D
V
P
K
S
W
L
M
K
L
F
T
F
Y
M
V
L
L
F
L
L
L
V
N
I
F
T
F
V
S
P
Q
L
L
K
L
L
I
S
F
A
S
D
-
-
-
-
-
353
ABCC3 279
-
N
A
S
G
E
D
E
V
L
L
G
A
R
P
-
R
P
R
K
P
S
-
-
-
-
-
-
-
-
-
-
F
L
K
A
L
L
A
F
S
S
F
L
I
S
A
C
F
K
L
I
Q
D
L
L
S
F
I
N
P
Q
L
L
S
I
L
I
R
F
I
S
N
-
-
-
-
-
342
ABCC4 78
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
L
T
R
A
I
I
K
C
Y
W
K
S
Y
L
V
L
G
I
F
T
L
I
E
E
S
A
K
V
I
Q
P
I
F
L
G
K
I
I
N
Y
F
E
N
Y
D
P
-
-
126
ABCC5 167
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
L
R
R
V
V
W
I
F
C
R
T
R
L
I
L
S
I
V
C
L
M
I
T
Q
L
A
G
F
S
G
P
A
F
M
V
K
H
L
L
E
Y
T
Q
A
-
-
-
-
211
ABCC6 279
G
M
A
P
E
T
E
P
F
L
R
Q
E
G
S
Q
W
R
P
-
-
-
-
-
-
-
-
-
-
-
-
L
L
K
A
I
W
Q
V
F
H
S
T
F
L
L
G
T
L
L
I
S
D
V
F
R
F
T
V
P
K
L
L
S
L
F
L
E
F
I
G
D
-
-
-
-
-
342
ABCC8 284
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
A
L
S
H
F
R
R
L
V
L
S
S
T
F
I
L
L
L
G
F
A
G
P
L
C
I
F
G
I
D
L
K
E
N
D
F
334
ABCC9 282
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
P
S
I
W
L
A
M
Y
R
A
F
G
R
P
I
L
L
S
S
T
F
R
Y
L
A
D
L
L
G
F
A
G
P
L
C
I
S
G
I
V
Q
R
V
N
E
T
Q
N
G
T
332
ABCC10 273
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
L
W
R
A
L
Y
G
A
F
G
R
C
Y
L
A
L
G
L
L
K
L
V
G
T
M
L
G
F
S
G
P
L
L
L
S
L
L
V
G
F
L
E
E
-
-
-
-
-
316
ABCC11 151
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
L
L
V
M
L
R
F
Q
R
T
R
L
I
F
D
A
L
L
G
I
C
F
C
I
A
S
V
L
P
I
L
I
I
P
K
I
L
E
Y
S
E
E
-
-
-
-
195
ABCC12 111
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
L
S
H
V
V
W
K
F
Q
R
T
R
V
L
M
D
I
V
A
N
I
L
C
I
I
M
A
A
I
G
P
V
I
L
I
H
Q
I
L
Q
Q
T
E
R
-
-
-
-
155