Mutations at homologous positions to ABCC7 p.Cys524
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Cys524*
p.Cys524Ser
p.Cys524Ala
p.Cys524Tyr
p.Cys524Thr
|
-
-
D
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCC2 |
p.Leu739Phe
p.Leu739Pro
|
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Ser519Gly
p.Val520Phe
p.Val520Ile
p.Ile521Phe
p.Gln525*
p.Leu526Ala
p.Glu527Gly
p.Glu527Gln
p.Glu527Asn
p.Glu528Asp
p.Glu528Gln
p.Glu528*
p.Asp529Phe
p.Asp529Asn
|
N
N
?
D
D
D
D
N
D
D
?
-
-
N
D
?
D
D
?
N
N
N
N
?
N
N
N
N
?
-
-
N
D
D
?
D
D
?
|
| ABCC1 |
p.Cys744Ala
|
N
D
?
|
| ABCC6 |
p.Leu726Pro
|
D
D
D
|
| ABCC8 |
p.Cys805Thr
p.Gln808Lys
|
N
D
?
N
D
?
|
The alignment around the queried position:
960ABCC7 487
-
-
I
I
G
K
G
D
E
K
A
E
N
V
G
I
S
564
ABCC1 707
S
V
A
Y
V
P
Q
A
W
I
Q
N
S
L
E
N
I
L
G
Q
L
E
E
P
Y
Y
R
S
V
I
Q
A
A
L
L
P
D
L
E
I
L
P
S
D
R
T
E
I
G
E
K
G
V
N
S
G
Q
K
Q
R
V
S
L
A
R
A
Y
S
N
A
786
ABCC2 700
T
T
A
Y
V
P
Q
Q
S
I
Q
N
G
T
I
K
D
I
L
F
T
E
F
N
E
K
R
Y
Q
Q
V
L
E
A
C
A
L
P
D
L
E
M
L
P
G
G
D
L
A
E
I
G
E
G
I
N
L
S
G
G
Q
K
Q
I
S
L
A
R
A
T
Y
Q
N
L
779
ABCC3 690
S
V
A
Y
V
P
Q
Q
A
W
I
Q
N
C
T
L
Q
E
N
V
L
F
G
K
A
L
N
P
R
Y
Q
Q
T
L
E
A
C
A
L
L
A
D
L
E
M
L
P
G
G
D
Q
E
I
G
E
K
G
I
N
L
S
G
G
Q
R
Q
R
V
S
L
A
R
A
Y
S
D
A
769
ABCC4 474
R
I
A
V
S
Q
Q
P
W
V
F
S
T
L
R
S
N
I
L
F
G
K
Y
E
K
E
R
Y
E
K
V
I
K
A
C
A
L
K
K
D
L
Q
L
L
E
D
G
D
L
T
V
I
G
D
G
T
T
L
S
G
Q
K
A
R
V
N
L
A
R
V
Y
Q
D
A
553
ABCC5 624
T
F
A
Y
V
A
Q
Q
A
W
I
L
N
A
T
L
R
D
N
I
L
F
G
K
E
Y
D
E
E
R
Y
N
S
V
L
N
S
C
C
L
R
P
D
L
A
I
L
P
S
S
D
L
T
E
I
G
E
R
G
A
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
L
Y
S
D
R
703
ABCC6 692
A
V
A
Y
V
P
A
W
V
Q
N
T
S
V
V
E
N
V
C
F
G
Q
E
L
P
P
W
L
E
V
E
A
C
A
L
Q
P
D
V
D
S
F
P
E
G
H
T
S
I
G
E
G
N
L
S
G
Q
K
Q
L
S
L
A
V
K
A
771
ABCC8 768
P
V
A
Y
A
S
K
P
W
L
L
N
A
T
V
E
E
N
I
I
F
E
S
P
F
N
K
Q
R
Y
K
M
V
I
E
A
S
L
P
D
I
D
I
H
G
Q
T
Q
I
G
E
G
I
N
L
G
G
Q
Q
I
S
V
A
A
L
Y
Q
H
A
847
ABCC9 751
S
V
A
Y
A
A
Q
K
P
W
L
L
N
A
T
V
E
E
N
I
T
F
G
S
P
F
N
K
Q
R
Y
K
A
V
T
D
A
C
S
L
Q
P
D
I
D
L
L
P
F
G
D
Q
T
E
I
G
E
R
G
I
N
L
S
G
G
Q
R
Q
R
I
C
V
A
R
A
L
Y
Q
N
T
830
ABCC10 666
-
F
G
L
A
T
Q
E
P
W
I
Q
F
A
T
I
R
D
N
I
L
F
G
K
T
F
D
A
Q
L
Y
K
E
V
L
E
A
C
A
L
N
D
D
L
S
I
L
P
A
G
D
Q
T
E
V
G
E
K
G
V
T
L
S
G
G
Q
R
A
R
I
A
L
A
R
A
V
Y
Q
E
K
744
ABCC11 573
S
L
A
Y
V
P
Q
Q
A
W
I
V
S
G
N
I
R
E
N
I
L
M
G
G
A
Y
D
K
A
R
Y
L
Q
V
L
H
C
C
S
L
N
R
D
L
E
L
L
P
F
G
D
M
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
K
Q
R
I
S
L
A
R
A
V
Y
S
D
R
652
ABCC12 542
T
L
A
Y
V
S
Q
Q
A
W
I
F
H
G
N
V
R
E
N
I
L
F
G
E
K
Y
D
H
Q
R
Y
Q
H
T
V
R
V
C
G
L
Q
K
D
L
S
N
L
P
Y
G
D
L
T
E
I
G
E
R
G
L
N
L
S
G
G
Q
R
Q
R
I
S
L
A
R
A
V
Y
S
D
R
621