Mutations at homologous positions to ABCC7 p.Leu320
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Leu320Phe
p.Leu320Val
|
N
N
N
N
D
|
| ABCC1 |
p.Cys563Ser
p.Cys563Ala
|
N
N
?
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Phe315Ser
p.Phe316Leu
p.Val317Ala
p.Val317Glu
p.Val317Gln
p.Val318Ala
p.Phe319Val
p.Ser321Ala
p.Val322Ala
p.Val322Met
p.Leu323Pro
p.Pro324Ala
p.Pro324Gly
p.Tyr325Cys
|
D
N
?
N
N
?
N
N
?
D
D
?
D
D
?
N
N
?
N
N
?
N
N
?
D
N
?
N
N
D
N
?
N
N
?
N
D
?
D
D
?
|
| ABCC1 |
p.Thr564Ala
p.Phe565Leu
p.Phe565Ser
p.Phe565Ala
p.Tyr568Ala
p.Tyr568Ser
p.Tyr568Trp
p.Tyr568Phe
|
N
D
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
D
?
|
| ABCC2 |
p.Phe562Leu
|
D
D
?
|
| ABCC3 |
p.Leu548Gln
p.Thr550Ala
|
D
D
?
D
D
?
|
| ABCC8 |
p.Ala553Gly
p.Val560Gly
p.Val560Met
p.Gly561Ser
|
N
N
?
N
N
?
D
N
N
N
N
?
|
The alignment around the queried position:
ABCC7 281
E
K
E
L
R
T
L
T
A
N
S
S
-
-
-
357
ABCC1 524
F
K
D
K
V
L
A
I
Q
E
L
K
V
L
K
S
A
Y
L
S
A
V
G
F
V
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
602
ABCC2 521
F
R
D
Q
V
Q
N
L
R
K
K
E
L
K
N
L
L
A
F
S
Q
L
Q
C
V
V
I
F
V
F
Q
L
T
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
599
ABCC3 510
F
L
K
V
E
G
I
Q
G
E
L
Q
L
L
R
A
Y
L
H
T
T
T
T
F
T
W
M
C
S
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
588
ABCC4 295
F
S
N
L
I
T
N
L
R
K
E
I
S
K
I
L
R
S
S
C
L
R
G
M
N
L
A
S
F
F
S
A
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
372
ABCC5 377
F
S
Q
S
V
Q
K
I
R
E
E
E
R
R
I
L
E
K
A
G
Y
F
Q
S
I
T
V
G
V
A
P
I
V
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
453
ABCC6 510
F
L
D
R
L
G
I
G
Q
L
G
A
L
R
T
S
G
L
L
F
S
V
L
V
S
F
Q
V
S
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
587
ABCC8 518
F
R
T
V
E
T
T
R
K
E
M
T
R
A
A
I
Y
T
S
I
S
I
F
M
N
T
A
I
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
596
ABCC9 514
F
C
K
S
V
E
E
T
R
M
K
E
L
S
L
K
T
F
A
L
Y
T
S
L
S
I
F
M
N
A
A
I
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
591
ABCC10 481
L
G
A
R
V
E
A
C
R
A
R
E
L
G
R
L
R
V
I
K
Y
L
D
A
A
C
V
Y
L
W
A
A
L
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
557
ABCC11 361
F
A
K
I
I
E
D
L
R
R
K
E
R
K
L
L
E
K
C
G
L
V
Q
S
L
T
S
I
T
L
F
I
I
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
437
ABCC12 321
F
T
N
T
I
Q
D
I
R
R
R
E
R
K
L
L
E
K
A
G
F
V
Q
S
G
N
S
A
L
A
P
I
V
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
397