Mutations at homologous positions to ABCC3 p.Ser1233
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC3 |
p.Ser1233Ala
|
N
N
?
|
| ABCC1 |
p.Ser1237Ala
|
N
N
?
|
| ABCC7 |
p.Ala1136Thr
p.Ala1136Cys
p.Ala1136Ser
|
N
N
?
D
D
?
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC3 |
p.Ser1229Ala
p.Ser1231Ala
p.Tyr1232Phe
p.Gln1235Ala
p.Thr1237Ala
p.Thr1237Ser
p.Thr1237Leu
p.Thr1237Gly
|
N
N
?
D
N
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
|
| ABCC1 |
p.Ser1233Ala
p.Ser1235Ala
p.Tyr1236Phe
p.Tyr1236Trp
p.Gln1239Ala
p.Thr1241Ala
p.Thr1242Ala
p.Thr1242Cys
p.Thr1242Ser
p.Thr1242Asp
p.Thr1242Lys
p.Thr1242Leu
|
N
N
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
|
| ABCC10 |
p.Tyr1190Ala
|
D
D
?
|
| ABCC11 |
p.Gln1086Glu
|
D
D
?
|
| ABCC2 |
p.Asn1244Lys
|
D
N
?
|
| ABCC7 |
p.Ile1131Val
p.Ile1131Cys
p.Ile1131Leu
p.Ile1132Cys
p.Leu1133Cys
p.Thr1134Phe
p.Thr1134Ala
p.Thr1134Glu
p.Thr1134Cys
p.Leu1135Cys
p.Leu1135Ala
p.Met1137Ala
p.Met1137Val
p.Met1137Arg
p.Met1137Cys
p.Met1137Thr
p.Asn1138Ala
p.Asn1138Cys
p.Ile1139Val
p.Ile1139Cys
p.Ile1139Ala
p.Met1140Lys
p.Met1140Cys
p.Met1140Ile
p.Met1140Ala
p.Met1140Leu
p.Ser1141Ala
p.Ser1141Lys
p.Ser1141Cys
p.Ser1141Arg
|
N
N
?
N
D
?
N
N
?
N
N
?
D
D
?
D
D
?
N
N
?
D
N
?
D
N
?
N
N
?
N
N
?
D
D
?
N
N
D
D
D
D
?
D
D
?
D
N
?
D
D
?
N
N
D
D
?
D
D
?
D
N
D
N
?
D
N
?
D
N
?
D
N
?
N
N
?
D
N
?
N
N
?
D
N
?
|
| ABCC8 |
p.Thr1285Leu
p.Met1289Thr
p.Met1289Leu
p.Val1290Gln
|
D
D
?
D
N
?
D
N
?
D
D
?
|
The alignment around the queried position:
ABCC3 1196
S
I
G
V
E
F
V
G
N
C
V
V
L
F
A
A
L
F
A
V
I
G
R
S
-
-
L
N
P
G
L
V
G
L
V
L
V
F
A
L
M
I
R
M
M
S
D
L
E
S
N
I
V
A
V
E
R
V
K
E
Y
S
K
T
E
T
E
-
-
-
-
1270
ABCC1 1200
A
V
L
V
I
V
L
A
A
L
F
A
V
I
S
H
S
-
-
L
S
G
L
V
G
L
V
L
V
L
L
V
M
S
S
E
M
E
T
N
I
V
A
V
E
R
L
K
E
S
E
T
E
K
E
-
-
-
-
1274
ABCC2 1208
A
I
L
E
L
V
G
N
L
T
V
F
F
S
A
L
M
M
V
I
Y
D
T
-
-
L
S
G
D
T
V
G
F
V
L
S
A
L
N
I
T
Q
T
L
N
L
V
M
T
S
E
I
E
T
N
I
V
A
V
E
R
I
E
T
K
V
E
N
E
-
-
-
-
1282
ABCC4 949
A
V
R
L
D
A
I
A
M
F
V
I
I
V
A
F
G
S
L
I
L
A
K
T
-
-
L
D
A
G
Q
V
G
L
A
L
S
Y
A
L
T
L
M
G
M
F
Q
C
V
Q
S
A
E
V
E
N
M
M
I
S
V
E
R
V
I
E
Y
T
D
L
E
K
E
-
-
-
-
1023
ABCC5 1099
A
V
R
L
D
L
I
S
I
A
L
I
T
T
T
G
L
M
I
V
L
M
H
G
Q
-
-
I
P
P
A
Y
A
G
L
A
I
S
Y
A
V
Q
L
T
G
L
F
Q
F
T
V
R
L
A
S
E
T
E
A
R
F
T
S
V
E
R
I
N
H
Y
I
K
T
L
S
L
-
-
-
-
1173
ABCC6 1172
A
A
N
V
E
L
L
G
N
L
V
F
A
A
A
T
C
A
V
L
S
K
A
H
-
-
L
S
A
G
L
V
F
S
V
S
A
A
L
Q
V
T
Q
T
L
Q
W
V
V
N
T
D
E
N
S
I
V
S
V
M
A
T
P
K
-
-
-
-
1246
ABCC7 1100
I
I
-
-
-
G
S
M
V
V
F
F
I
M
P
T
E
K
P
T
1176
ABCC8 1248
E
M
E
Y
G
C
V
V
I
A
V
T
S
I
S
N
S
L
H
R
E
L
S
A
G
L
V
G
L
G
L
Y
A
L
S
N
Y
L
N
W
M
V
R
N
L
A
D
M
L
Q
L
G
A
V
K
R
I
H
L
L
K
T
E
A
-
-
-
-
1324
ABCC9 1220
E
V
R
T
D
Y
L
G
A
C
I
V
L
T
A
S
I
A
S
I
S
G
S
S
N
-
-
-
-
S
G
L
V
L
G
L
L
Y
A
L
T
I
T
N
Y
L
N
W
V
V
R
N
L
A
D
L
E
V
Q
M
G
A
V
K
K
V
N
S
F
L
T
M
E
S
E
-
-
-
-
1292
ABCC10 1152
D
I
R
L
Q
L
M
G
A
A
V
V
S
A
I
A
G
I
A
L
V
Q
H
Q
Q
G
L
A
N
P
G
L
V
G
L
S
L
S
A
L
S
L
T
G
L
L
S
G
L
V
S
S
F
T
Q
T
E
A
M
L
V
S
V
E
R
L
E
E
Y
T
C
D
L
P
Q
-
-
-
-
1228
ABCC11 1047
A
L
R
L
E
I
M
T
N
L
V
T
L
A
V
A
L
F
V
A
F
G
I
S
S
-
-
T
P
Y
S
F
K
V
M
A
V
N
I
V
L
L
A
S
S
F
Q
A
T
A
I
G
L
E
T
E
A
Q
F
T
A
V
E
R
I
L
Q
Y
M
K
M
C
V
S
-
-
-
-
1121
ABCC12 1026
A
L
R
M
D
V
L
M
N
I
L
T
F
T
V
A
L
L
V
T
L
S
F
S
S
-
-
I
S
T
S
S
K
L
S
L
S
Y
I
I
Q
L
S
G
L
L
Q
V
C
V
R
T
G
T
E
T
Q
A
K
F
T
S
V
E
L
L
R
E
Y
I
S
T
C
V
P
-
-
-
-
1100