ABCC8 p.Met1289Thr

Predicted by SNAP2: A: D (59%), C: D (75%), D: D (75%), E: D (63%), F: D (71%), G: D (71%), H: D (80%), I: D (66%), K: D (66%), L: D (66%), N: D (59%), P: D (85%), Q: N (66%), R: D (63%), S: N (53%), T: D (53%), V: D (63%), W: D (85%), Y: D (75%),
Predicted by PROVEAN: A: N, C: N, D: N, E: N, F: N, G: N, H: N, I: N, K: N, L: N, N: N, P: N, Q: N, R: N, S: N, T: N, V: N, W: N, Y: N,

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[hide] Hambrock A, de Oliveira Franz CB, Hiller S, Grenz A, Ackermann S, Schulze DU, Drews G, Osswald H
Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner.
J Biol Chem. 2007 Feb 2;282(5):3347-56. Epub 2006 Nov 30., [PMID:17138562]

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[hide] Ackermann S, Hiller S, Osswald H, Losle M, Grenz A, Hambrock A
17beta-Estradiol modulates apoptosis in pancreatic beta-cells by specific involvement of the sulfonylurea receptor (SUR) isoform SUR1.
J Biol Chem. 2009 Feb 20;284(8):4905-13. Epub 2008 Dec 18., [PMID:19095654]

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[hide] Hambrock A, de Oliveira Franz CB, Hiller S, Osswald H
Glibenclamide-induced apoptosis is specifically enhanced by expression of the sulfonylurea receptor isoform SUR1 but not by expression of SUR2B or the mutant SUR1(M1289T).
J Pharmacol Exp Ther. 2006 Mar;316(3):1031-7. Epub 2005 Nov 23., [PMID:16306272]

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[hide] Hambrock A, Kayar T, Stumpp D, Osswald H
Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.
Diabetes. 2004 Dec;53 Suppl 3:S128-34., [PMID:15561900]

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