Mutations at homologous positions to ABCB4 p.Ala286
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCB4 |
p.Ala286Val
|
N
D
?
|
ABCB3 |
p.Cys362Ala
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
ABCB1 |
p.Asn280Cys
p.Lys285Thr
p.Gly288Val
|
N
D
?
N
D
?
D
D
?
|
ABCB11 |
p.Gln312His
p.Arg313Ser
p.Thr965Ser
|
N
N
?
N
N
?
N
N
?
|
The alignment around the queried position:
ABCB4 247
A
A
Y
K
A
G
V
A
E
E
A
L
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
T
L
V
I
S
-
326
ABCB1 245
L
A
Y
A
K
A
A
V
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
L
A
S
A
L
Y
G
L
V
S
-
324
ABCB1 888
K
E
L
E
G
K
I
A
T
E
A
I
E
N
T
V
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
R
F
G
A
Y
L
V
A
H
-
967
ABCB2 418
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
P
T
V
R
S
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
G
G
Q
L
V
T
S
-
497
ABCB3 323
D
A
V
A
R
A
G
Q
V
R
E
A
V
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
L
Y
L
L
R
V
L
H
L
G
V
Q
M
L
M
L
S
G
L
Q
Q
M
Q
D
-
402
ABCB4 887
K
L
E
A
A
G
K
I
A
T
E
A
I
E
N
I
R
T
V
V
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
F
S
Y
C
F
F
G
A
Y
L
I
V
N
-
966
ABCB5 423
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
F
I
Y
F
A
Y
A
A
G
F
R
F
G
A
Y
L
I
Q
A
-
502
ABCB6 444
T
Q
E
N
A
T
R
A
R
V
D
S
L
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
V
I
G
L
G
L
L
A
G
S
L
L
C
A
Y
F
V
T
E
-
523
ABCB7 324
K
A
D
N
D
A
G
N
A
A
I
D
S
L
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
I
F
S
V
G
L
T
A
I
M
V
L
A
S
Q
G
V
A
-
403
ABCB8 325
E
Q
I
A
R
A
M
G
V
A
D
E
A
L
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
A
F
N
C
M
V
L
G
T
L
F
I
G
G
S
L
V
A
G
-
404
ABCB9 359
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
M
K
T
V
R
S
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
T
L
L
V
V
Q
V
S
I
L
Y
Y
G
G
H
L
V
I
S
-
438
ABCB10 345
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
-
424
ABCB11 272
K
A
Y
A
K
G
V
V
A
D
I
S
S
M
R
T
A
A
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
L
I
F
L
A
A
F
Y
G
S
T
L
V
L
D
E
351
ABCB11 931
A
L
E
M
V
G
Q
T
N
E
A
L
S
N
I
T
V
A
G
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
I
M
F
I
A
N
S
A
S
Y
R
Y
Y
I
S
-
1010