Mutations at homologous positions to ABCB11 p.Cys336
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
| SNAP2 PROVEAN Effect_dbs | ||
|---|---|---|
| ABCB11 | p.Cys336Ser | N N ? | 
| ABCB1 | p.Ser952Ala p.Ser952Arg | N N ? D D ? | 
Mutations +/- 5 a.a. around the position:
| ABCB11 | p.Tyr337His p.Leu339Val | D D ? N N ? | 
| ABCB1 | p.Leu304Cys p.Ile306Cys p.Ile306Glu p.Ile306Arg p.Ile306Ala p.Tyr307Cys p.Tyr307Phe p.Tyr307Arg p.Tyr310Phe p.Ala313Gly p.Phe314Cys p.Ala947Leu p.Ala947Cys p.Ala947Val p.Met948Ala p.Met948Ile p.Met949Ala p.Met949Cys p.Met949Arg p.Tyr950Ala p.Tyr950Cys p.Tyr950Phe p.Tyr950Arg p.Phe951Ala p.Tyr953Ala p.Tyr953Cys p.Tyr953Phe p.Tyr953Arg p.Ala954Leu p.Ala954Cys p.Gly955Val p.Cys956Ala p.Cys956Ser p.Phe957Ala p.Phe957Cys | N D ? D D ? D D ? D D ? D D ? D D ? N N ? D D ? N D ? N D ? N D ? D D ? N N ? D D ? N D ? N N ? D D ? D D ? D D ? D D ? D D ? N N ? D D ? N D ? D D ? D D ? N D ? D D ? D D ? N D ? N D ? N D ? N D ? N D ? N D ? | 
| ABCB4 | p.Ala946Thr p.Phe947Ala p.Met948Ile p.Tyr949Ala p.Tyr949Phe p.Tyr949Gln p.Ala953Asp p.Gly954Ser | N D ? N N ? N N ? D D ? N N ? D D ? D D ? N N ? | 
The alignment around the queried position:
ABCB11 297
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
L
I
F
L
A
A
F
Y
G
S
T
L
V
L
D
E
G
E
T
P
G
T
L
V
Q
I
F
L
S
V
I
V
G
A
L
N
L
N
A
    
        376
        ABCB1 270
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
L
A
S
A
L
Y
G
L
V
S
-
Y
I
G
V
    
        348
        ABCB1 913
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
R
F
G
A
Y
L
V
A
H
-
K
L
M
S
F
E
D
V
V
    
        991
        ABCB2 443
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
G
G
Q
L
V
T
S
-
G
A
V
S
S
G
N
L
V
T
F
V
L
Y
Q
M
Q
F
T
Q
A
E
V
L
    
        521
        ABCB3 348
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
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Y
L
L
R
V
L
H
L
G
V
Q
M
L
M
L
S
G
L
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Q
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D
-
G
E
L
T
Q
G
S
L
S
F
M
I
Y
Q
E
S
V
G
S
Y
V
Q
T
L
    
        426
        ABCB4 272
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
T
L
V
I
S
-
K
E
T
I
G
N
A
M
T
V
F
F
S
I
L
I
G
A
F
V
G
Q
A
    
        350
        ABCB4 912
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
F
S
Y
C
F
F
G
A
Y
L
I
V
N
-
G
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M
R
F
R
D
V
I
V
F
A
I
V
F
A
V
A
L
G
H
A
    
        990
        ABCB5 448
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
F
I
Y
F
A
Y
A
A
G
F
R
F
G
A
Y
L
I
Q
A
-
G
R
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T
P
E
G
M
F
I
V
F
T
A
I
A
Y
G
A
A
I
G
E
T
    
        526
        ABCB6 469
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
V
I
G
L
G
L
L
A
G
S
L
L
C
A
Y
F
V
T
E
-
Q
K
L
Q
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G
D
Y
V
L
F
G
T
Y
I
I
Q
L
Y
M
P
L
N
W
F
    
        547
        ABCB7 349
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
I
F
S
V
G
L
T
A
I
M
V
L
A
S
Q
G
V
A
-
G
T
L
T
V
G
D
L
M
V
N
G
L
L
F
Q
L
S
L
P
L
N
F
L
    
        427
        ABCB8 350
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
A
F
N
C
M
V
L
G
T
L
F
I
G
G
S
L
V
A
G
-
Q
Q
L
T
G
G
D
L
M
S
F
L
V
A
S
Q
T
V
Q
R
S
M
A
N
L
    
        428
        ABCB9 384
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
T
L
L
V
V
Q
V
S
I
L
Y
Y
G
G
H
L
V
I
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-
G
Q
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T
S
G
N
L
I
A
F
I
I
Y
E
F
V
L
G
D
C
M
E
S
V
    
        462
        ABCB10 370
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
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A
G
F
F
G
A
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G
N
L
I
V
L
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Y
K
G
G
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-
A
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M
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V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
    
        448
        ABCB11 956
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
I
M
F
I
A
N
S
A
S
Y
R
Y
Y
I
S
-
E
G
L
H
F
S
Y
V
F
R
V
I
S
A
V
V
L
S
A
A
L
R
A
    
        1034
        