Mutations at homologous positions to ABCC8 p.Glu1326
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCC8 |
p.Glu1326Lys
|
N
D
?
|
Mutations +/- 5 a.a. around the position:
ABCC8 |
p.Glu1323Lys
|
D
D
?
|
ABCC2 |
p.Thr1286Cys
|
N
N
?
|
ABCC6 |
p.Glu1245Asp
|
N
D
D
|
ABCC7 |
p.Met1191Ile
p.Glu1194Ala
p.Ser1196*
p.Ser1196Thr
|
N
N
?
N
N
?
-
-
D
N
N
?
|
The alignment around the queried position:
ABCC8 1304
M
L
Q
L
G
A
V
K
R
I
H
L
L
K
T
E
A
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
Y
G
L
L
A
P
S
L
I
P
K
N
W
P
D
Q
K
I
Q
I
Q
N
L
S
V
R
Y
D
S
L
K
P
V
L
K
H
V
N
1366
ABCC1 1254
M
E
T
N
I
V
A
V
E
R
L
K
E
S
E
T
E
K
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
W
-
Q
I
Q
E
T
A
P
P
S
S
W
P
Q
G
R
V
E
N
L
R
E
D
L
D
F
V
L
R
H
I
N
V
1315
ABCC2 1262
I
E
T
N
I
V
A
V
E
R
I
E
T
K
V
E
N
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
W
-
V
D
-
K
R
P
P
D
W
P
S
K
G
I
Q
F
N
N
Y
Q
V
R
Y
P
E
L
D
L
V
L
R
G
I
T
C
1322
ABCC3 1250
L
E
S
N
I
V
A
V
E
R
V
K
E
Y
S
K
T
E
T
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
W
-
V
V
E
G
S
R
P
P
E
G
W
P
P
G
E
V
E
F
R
N
Y
S
V
Y
R
G
L
D
L
V
L
R
D
L
S
L
1311
ABCC4 1003
V
E
N
M
M
I
S
V
E
R
V
I
E
Y
T
D
L
E
K
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
W
E
Y
Q
K
-
-
R
P
P
P
A
W
P
H
E
G
V
I
I
F
D
N
V
N
F
M
Y
S
P
G
G
P
L
V
L
K
H
L
1063
ABCC5 1153
T
E
A
R
F
T
S
V
E
R
I
N
H
Y
I
K
T
L
S
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
A
P
A
R
I
K
N
K
A
P
S
P
D
W
P
Q
E
G
E
V
T
F
E
N
A
E
M
R
Y
R
N
L
P
L
V
L
K
K
V
S
F
1215
ABCC6 1226
E
N
S
I
V
S
V
M
A
T
P
K
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
W
-
R
L
P
T
C
A
A
Q
P
P
P
Q
G
Q
I
E
F
D
F
G
L
Y
P
E
L
P
L
A
V
Q
G
V
S
F
1287
ABCC7 1153
S
M
V
V
F
F
I
M
P
T
E
K
P
T
S
T
P
K
N
G
Q
L
S
K
V
I
I
N
H
K
D
D
P
G
T
K
D
L
T
A
E
G
G
I
N
S
1232
ABCC9 1272
L
E
V
Q
M
G
A
V
K
K
V
N
S
F
L
T
M
E
S
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
N
Y
E
G
T
M
D
P
S
Q
V
P
E
H
W
P
Q
E
G
E
I
K
I
H
D
L
C
V
R
Y
E
N
N
L
K
P
V
L
K
H
V
A
1334
ABCC10 1208
T
E
A
M
L
V
S
V
E
R
L
E
E
Y
T
C
D
L
P
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
P
Q
-
G
Q
P
L
Q
L
G
T
G
-
W
L
T
Q
G
G
V
E
F
Q
D
V
V
L
A
Y
R
P
G
L
P
N
A
L
D
G
V
T
F
1268
ABCC11 1101
T
E
A
Q
F
T
A
V
E
R
I
L
Q
Y
M
K
M
C
V
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
A
P
L
H
M
E
G
T
S
C
P
Q
G
W
P
Q
H
G
E
I
I
F
Q
D
Y
H
M
K
Y
R
D
N
T
P
T
V
L
H
G
I
N
L
1163
ABCC12 1080
T
Q
A
K
F
T
S
V
E
L
L
R
E
Y
I
S
T
C
V
P
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
C
T
H
P
L
K
V
G
T
C
P
K
D
W
P
S
R
G
E
I
T
F
R
D
Y
Q
R
Y
R
D
N
T
P
L
V
L
D
S
L
N
L
1142