ABCC3 p.Arg1297His

Predicted by SNAP2: A: D (66%), C: D (71%), D: D (91%), E: D (85%), F: D (85%), G: D (80%), H: D (95%), I: D (80%), K: D (63%), L: D (95%), M: D (75%), N: D (95%), P: D (91%), Q: N (61%), S: D (91%), T: D (66%), V: D (75%), W: D (85%), Y: D (80%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Gradhand U, Kim RB
Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2).
Drug Metab Rev. 2008;40(2):317-54., [PMID:18464048]

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[hide] Muller PJ, Dally H, Klappenecker CN, Edler L, Jager B, Gerst M, Spiegelhalder B, Tuengerthal S, Fischer JR, Drings P, Bartsch H, Risch A
Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients.
Int J Cancer. 2009 Apr 1;124(7):1669-74., 2009-04-01 [PMID:19107936]

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[hide] Conseil G, Deeley RG, Cole SP
Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.
Pharmacogenet Genomics. 2005 Aug;15(8):523-33., [PMID:16006996]

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[hide] Yu XQ, Xue CC, Wang G, Zhou SF
Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs.
Curr Drug Metab. 2007 Dec;8(8):787-802., [PMID:18220559]

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[hide] Stieger B, Meier PJ
Pharmacogenetics of drug transporters in the enterohepatic circulation.
Pharmacogenomics. 2011 May;12(5):611-31., [PMID:21619426]

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[hide] Klaassen CD, Aleksunes LM
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Pharmacol Rev. 2010 Mar;62(1):1-96. Epub 2010 Jan 26., [PMID:20103563]

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[hide] Nies AT, Schwab M, Keppler D
Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.
Expert Opin Drug Metab Toxicol. 2008 May;4(5):545-68., [PMID:18484914]

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[hide] Ansari M, Sauty G, Labuda M, Gagne V, Rousseau J, Moghrabi A, Laverdiere C, Sinnett D, Krajinovic M
Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia.
Pharmacogenomics J. 2012 Oct;12(5):386-94. doi: 10.1038/tpj.2011.17. Epub 2011 May 24., [PMID:21606946]

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[hide] Kobayashi K, Ito K, Takada T, Sugiyama Y, Suzuki H
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.
Pharmacogenet Genomics. 2008 Sep;18(9):823-33., [PMID:18698235]

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[hide] Campa D, Vodicka P, Pardini B, Novotny J, Forsti A, Hemminki K, Barale R, Canzian F
Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?
Eur J Cancer. 2008 Apr;44(6):854-7. Epub 2008 Mar 7., [PMID:18313914]

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[hide] Fukushima-Uesaka H, Saito Y, Maekawa K, Hasegawa R, Suzuki K, Yanagawa T, Kajio H, Kuzuya N, Noda M, Yasuda K, Tohkin M, Sawada J
Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.
Drug Metab Pharmacokinet. 2007 Apr;22(2):129-35., [PMID:17495421]

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[hide] Gradhand U, Tegude H, Burk O, Eichelbaum M, Fromm MF, Konig J
Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene.
Life Sci. 2007 Mar 27;80(16):1490-4. Epub 2007 Jan 20., [PMID:17300812]

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[hide] Lee YM, Cui Y, Konig J, Risch A, Jager B, Drings P, Bartsch H, Keppler D, Nies AT
Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).
Pharmacogenetics. 2004 Apr;14(4):213-23., [PMID:15083066]

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[hide] Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF
Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.
Pharmacogenetics. 2004 Mar;14(3):155-64., [PMID:15167703]

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[hide] Kelly L, Fukushima H, Karchin R, Gow JM, Chinn LW, Pieper U, Segal MR, Kroetz DL, Sali A
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
Protein Sci. 2010 Nov;19(11):2110-21., [PMID:20799350]

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[hide] Kerb R
Implications of genetic polymorphisms in drug transporters for pharmacotherapy.
Cancer Lett. 2006 Mar 8;234(1):4-33. Epub 2006 Feb 28., [PMID:16504381]

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[hide] Giraud C, Manceau S, Treluyer JM
ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies.
Expert Opin Drug Metab Toxicol. 2010 May;6(5):571-89., [PMID:20367109]

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[hide] Kock K, Grube M, Jedlitschky G, Oevermann L, Siegmund W, Ritter CA, Kroemer HK
Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy.
Clin Pharmacokinet. 2007;46(6):449-70., [PMID:17518506]

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[hide] Ulzurrun E, Stephens C, Ruiz-Cabello F, Robles-Diaz M, Saenz-Lopez P, Hallal H, Soriano G, Roman E, Fernandez MC, Lucena MI, Andrade RJ
Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.
PLoS One. 2014 Apr 14;9(4):e94675. doi: 10.1371/journal.pone.0094675. eCollection 2014., [PMID:24732756]

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[hide] Templeton I, Eichenbaum G, Sane R, Zhou J
Case study 5. Deconvoluting hyperbilirubinemia: differentiating between hepatotoxicity and reversible inhibition of UGT1A1, MRP2, or OATP1B1 in drug development.
Methods Mol Biol. 2014;1113:471-83. doi: 10.1007/978-1-62703-758-7_22., [PMID:24523126]

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