ABCMdb

PMID: 9441945

Ueda K, Taguchi Y, Morishima M
How does P-glycoprotein recognize its substrates?
Semin Cancer Biol. 1997 Jun;8(3):151-9., [PubMed]

Sentences

No. Mutations Sentence Comment

80 ABCB1 p.Gly185Val associated with a Gly-to-Val substitution at position 185, in the predicted cytoplasmic loop between TM2 and TM3. Login to comment 98 ABCB1 p.Gly185Val ABCB1 p.Val338Ala ABCB1 p.Phe335Ala ABCB1 p.Gly830Val ABCB1 p.Gly812Val ABCB1 p.Gly141Val The effects of amino acid substitutions on substrate specificity of P-glycoprotein can generally be classified into two groups.46 The first group is of mutations Gly185-to-Val, 51,52 Gly141-to-Val, and Gly187- to-Val,54 all in the first cytoplasmic loop; Gly288-to- Val54 in the second cytoplasmic loop; Phe335-to-Ala 39 and Val338-to-Ala 40 in TM6; Gly812-to-Val and Gly830-to-Val 54 in the fourth cytoplasmic loop. Login to comment 100 ABCB1 p.Pro866Ala ABCB1 p.Phe978Ala ABCB1 p.Pro223Ala ABCB1 p.Gly341Val ABCB4 p.Tyr949Ala The other group consists of mutations Pro223-to-Ala 46 in TM4; Gly341-to-Val 40 in TM6; Pro866-to-Ala 46 in TM10; Phe978-to-Ala 39 in TM12; Ser939-to-Phe, Tyr949-to-Ala, and Phe953-to-Ala in TM11 of mouse mdr1;42,44 and Ser941-to-Phe 43 in TM11 of mouse mdr3. Login to comment