Mutations at homologous positions to ABCC7 p.Ala1113
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Ala1113Cys
|
N
N
?
|
| ABCC1 |
p.Phe1213Trp
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Val1108Leu
p.Ile1109Cys
p.Phe1110Cys
p.Phe1111Ser
p.Phe1111Cys
p.Ile1112Cys
p.Val1114Cys
p.Thr1115Cys
p.Thr1115Ala
p.Phe1116Cys
p.Ile1117Cys
p.Ser1118Phe
p.Ser1118Ala
p.Ser1118Cys
p.Ser1118Val
p.Ser1118Gln
p.Ser1118Thr
|
N
N
N
N
?
N
D
?
D
D
?
N
N
?
N
N
?
D
N
?
N
N
?
N
N
?
N
N
?
N
N
?
D
N
N
N
?
N
N
N
N
?
D
N
?
N
N
?
|
| ABCC1 |
p.Asn1208Ala
p.Cys1209Ser
p.Cys1209Ala
|
D
D
?
D
D
?
N
D
?
|
| ABCC6 |
p.Gly1181Asp
|
D
N
?
|
| ABCC8 |
p.Ala1256Thr
p.Leu1260Ala
p.Leu1260Trp
p.Leu1260Ile
p.Leu1260Gly
p.Ala1263Thr
|
N
D
?
N
D
?
D
D
?
N
N
?
N
D
?
N
N
?
|
The alignment around the queried position:
ABCC7 1074
E
T
F
H
L
N
L
F
L
S
T
R
I
I
-
-
-
G
1150
ABCC1 1174
F
I
H
Q
S
L
V
N
Q
K
A
S
I
V
A
N
L
A
V
L
V
I
V
L
A
A
L
F
A
V
I
S
H
S
-
-
L
S
G
L
V
G
L
V
L
V
L
L
V
M
S
1251
ABCC2 1182
F
L
K
H
N
E
R
I
D
T
N
Q
K
C
V
F
S
W
I
T
S
N
R
W
L
A
I
L
E
L
V
G
N
L
T
V
F
F
S
A
L
M
M
V
I
Y
D
T
-
-
L
S
G
D
T
V
G
F
V
L
S
A
L
N
I
T
Q
T
L
N
L
V
M
T
1259
ABCC3 1170
F
E
I
S
D
T
K
V
D
A
N
Q
R
S
C
Y
P
Y
I
I
S
N
R
W
L
S
I
G
V
E
F
V
G
N
C
V
V
L
F
A
A
L
F
A
V
I
G
R
S
-
-
L
N
P
G
L
V
G
L
V
L
V
F
A
L
M
I
R
M
M
1247
ABCC4 923
C
Q
E
L
F
D
A
H
Q
D
L
H
S
E
A
W
F
L
F
L
T
T
S
R
W
F
A
V
R
L
D
A
I
A
M
F
V
I
I
V
A
F
G
S
L
I
L
A
K
T
-
-
L
D
A
G
Q
V
G
L
A
L
S
Y
A
L
T
L
M
G
M
F
Q
C
V
Q
S
1000
ABCC5 1073
F
L
H
R
Y
Q
E
L
L
D
D
N
Q
A
P
F
F
L
F
T
C
A
M
W
L
A
V
R
L
D
L
I
S
I
A
L
I
T
T
T
G
L
M
I
V
L
M
H
G
Q
-
-
I
P
P
A
Y
A
G
L
A
I
S
Y
A
V
Q
L
T
G
L
F
Q
F
T
V
R
L
A
1150
ABCC6 1146
F
V
A
Q
N
N
A
R
V
D
E
S
Q
R
I
S
F
P
L
V
A
D
R
W
L
A
A
N
V
E
L
L
G
N
L
V
F
A
A
A
T
C
A
V
L
S
K
A
H
-
-
L
S
A
G
L
V
F
S
V
S
A
A
L
Q
V
T
Q
T
L
Q
W
V
V
N
1223
ABCC8 1222
F
Q
K
L
E
T
D
S
N
N
I
A
L
F
L
T
A
A
N
R
W
L
E
M
E
Y
G
C
V
V
I
A
V
T
S
I
S
N
S
L
H
R
E
L
S
A
G
L
V
G
L
G
L
Y
A
L
S
N
Y
L
N
W
M
V
R
N
L
1301
ABCC9 1194
F
K
Q
L
E
L
T
D
T
N
N
I
A
Y
L
F
L
S
A
A
N
R
W
L
E
V
R
T
D
Y
L
G
A
C
I
V
L
T
A
S
I
A
S
I
S
G
S
S
N
-
-
-
-
S
G
L
V
L
G
L
L
Y
A
L
T
I
T
N
Y
L
N
W
V
V
R
N
L
1269
ABCC10 1126
F
E
E
E
N
L
R
L
L
E
L
N
Q
R
C
Q
F
A
T
S
A
T
M
Q
W
L
D
I
R
L
Q
L
M
G
A
A
V
V
S
A
I
A
G
I
A
L
V
Q
H
Q
Q
G
L
A
N
P
G
L
V
G
L
S
L
S
A
L
S
L
T
G
L
L
S
G
L
V
S
S
F
1205
ABCC11 1021
F
I
S
Q
F
K
R
L
T
D
A
Q
N
N
Y
L
L
L
F
L
S
S
T
R
W
M
A
L
R
L
E
I
M
T
N
L
V
T
L
A
V
A
L
F
V
A
F
G
I
S
S
-
-
T
P
Y
S
F
K
V
M
A
V
N
I
V
L
L
A
S
S
F
Q
A
T
A
I
G
1098
ABCC12 1010
C
I
T
-
-
-
-
-
-
-
-
-
-
Y
H
L
L
Y
F
N
C
A
L
R
W
F
A
L
R
M
D
V
L
M
N
I
L
T
F
T
V
A
L
L
V
T
L
S
F
S
S
-
-
I
S
T
S
S
K
L
S
L
S
Y
I
I
Q
L
S
G
L
L
Q
V
C
V
R
T
G
1077