Mutations at homologous positions to ABCB1 p.Arg492
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Arg492Cys
|
N
D
?
|
| ABCB11 |
p.Arg520*
|
-
-
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ile488Cys
p.Arg489Cys
p.Tyr490Cys
p.Val495Cys
p.Ser1137Ile
|
N
D
?
N
D
?
N
D
?
N
D
?
N
D
?
|
| ABCB11 |
p.Asn515Thr
p.Arg517His
p.Asn1173Asp
p.Ile1183Thr
|
D
D
?
N
D
?
D
D
?
D
D
?
|
| ABCB2 |
p.Gln665Ala
|
N
N
?
|
| ABCB3 |
p.Ala565Thr
p.Cys571Ser
|
N
N
?
N
D
?
|
| ABCB4 |
p.Ile490Thr
p.Gly495Ala
p.Ile1137Ser
|
D
D
?
N
N
?
D
D
?
|
The alignment around the queried position:
801ABCB1 454
D
I
R
T
I
N
V
R
L
E
I
G
-
V
V
E
P
V
L
F
A
T
T
I
A
E
N
G
E
N
-
-
T
M
E
-
A
V
K
A
A
Y
F
I
M
F
L
E
G
529
ABCB1 1097
D
E
I
K
R
L
N
V
R
A
H
L
G
-
I
V
S
E
P
I
L
F
D
S
I
A
E
N
I
A
Y
G
D
N
R
V
V
Q
E
-
V
R
A
A
K
E
A
N
I
H
A
E
S
P
N
Y
S
V
G
D
K
G
T
1174
ABCB2 625
D
G
K
P
L
Q
Y
E
H
R
Y
L
H
R
Q
V
A
-
A
V
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
-
-
K
P
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
E
A
G
S
701
ABCB3 530
D
E
K
P
I
S
Q
Y
E
H
Y
L
H
S
Q
V
V
-
S
V
G
Q
P
V
L
F
S
G
S
V
R
N
N
I
Y
G
L
-
-
-
Q
S
E
D
D
K
V
A
A
A
Q
A
A
H
A
D
D
F
I
Q
E
M
E
H
G
I
Y
T
D
V
G
K
G
S
605
ABCB4 456
D
G
Q
I
R
N
F
N
V
N
L
R
E
I
I
G
-
V
S
Q
E
V
F
S
T
T
I
A
E
N
C
Y
G
R
N
-
-
V
T
M
D
E
-
I
K
K
A
V
K
E
A
Y
E
F
I
M
K
P
Q
K
F
D
T
L
G
R
G
A
531
ABCB4 1103
D
G
Q
E
A
K
K
L
N
V
Q
W
L
R
A
L
G
-
I
V
S
Q
P
I
L
F
D
C
S
I
A
E
N
A
Y
G
D
N
S
R
V
V
S
Q
D
E
-
I
V
S
A
A
K
A
A
N
I
H
F
I
E
T
L
P
H
K
E
T
R
V
G
D
K
T
1180
ABCB5 632
D
G
V
D
A
K
E
L
N
V
Q
W
L
R
S
Q
I
A
-
I
V
P
Q
E
P
V
L
F
N
C
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
P
L
D
E
-
I
K
E
A
A
N
A
N
I
H
S
F
I
E
G
L
P
E
K
Y
N
T
Q
V
G
L
K
G
A
709
ABCB6 650
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
-
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
R
-
-
-
V
T
A
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
725
ABCB7 532
A
G
Q
N
I
Q
D
V
S
L
E
S
L
R
R
A
V
G
-
V
V
P
Q
D
A
V
L
F
H
N
T
I
Y
Y
N
L
L
Y
G
N
-
-
-
I
S
A
S
P
E
E
V
Y
A
V
A
K
L
A
G
L
H
D
A
I
L
R
M
P
H
G
Y
D
T
Q
V
G
E
R
G
L
607
ABCB8 534
D
G
R
D
L
R
T
L
D
P
S
W
L
R
G
Q
V
V
G
F
I
S
Q
E
P
V
L
F
G
T
T
I
M
E
N
I
R
F
G
K
-
-
-
L
E
A
S
D
E
E
V
Y
T
A
A
R
E
A
N
A
H
E
F
I
T
S
F
P
E
G
Y
N
T
V
V
G
E
R
G
T
610
ABCB9 566
D
G
K
P
I
S
A
Y
D
H
K
Y
L
H
R
V
I
S
-
L
V
S
Q
E
P
V
L
F
A
R
S
I
T
D
N
I
S
Y
G
L
-
-
-
P
T
V
P
F
E
M
V
V
E
A
A
Q
K
A
N
A
H
G
F
I
M
E
L
Q
D
G
Y
S
T
E
T
G
E
K
G
A
641
ABCB10 554
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
-
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
632
ABCB11 482
G
H
D
I
S
L
I
Q
L
R
D
Q
-
I
V
E
Q
E
P
V
L
F
S
T
T
A
E
I
Y
G
E
D
-
-
A
T
M
E
D
-
V
Q
A
A
K
E
A
N
A
Y
N
M
D
L
P
Q
T
L
V
G
E
G
G
557
ABCB11 1140
D
G
H
D
K
N
V
Q
F
L
N
I
G
-
I
V
S
Q
E
P
V
L
F
A
C
S
I
M
D
I
K
Y
G
D
N
T
K
E
P
M
R
-
V
I
A
A
A
K
Q
A
Q
D
F
V
M
S
L
P
E
K
E
G
S
G
S
1217