Mutations at homologous positions to ABCB4 p.Phe941

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

		SNAP2 PROVEAN Effect_dbs
ABCB4	p.Met301Thr details p.Phe941Ser details	N D ? D D ?
ABCB1	p.Ile299Met details p.Ile299Cys details p.Phe942Ala details p.Phe942Cys details p.Phe942Arg details	N N ? N N ? D D ? D D ? D D ?

Mutations +/- 5 a.a. around the position:

ABCB4	p.Ile299Met details p.Ile299Cys details p.Gly302Ala details p.Ile936Ala details p.Gln945* details p.Ala946Thr details	N N ? N D ? D D ? N D ? - - ? N D ?
ABCB1	p.Thr294Cys details p.Thr294Ala details p.Ala295Cys details p.Asn296Cys details p.Asn296Ala details p.Ile297Cys details p.Ile297Arg details p.Ser298Cys details p.Ser298Ala details p.Ser298Arg details p.Gly300Val details p.Ala301Thr details p.Ala301Val details p.Ala301Cys details p.Ala301Asp details p.Ala302Cys details p.Ala302Arg details p.Phe303Cys details p.Phe303Arg details p.Leu304Cys details p.Ile937Ser details p.Ile937Cys details p.Phe938Ala details p.Phe938Cys details p.Gly939Val details p.Gly939Cys details p.Ile940Ser details p.Ile940Cys details p.Thr941Ala details p.Thr941Cys details p.Thr941Gly details p.Ser943Ala details p.Ser943Cys details p.Phe944Ala details p.Phe944Cys details p.Thr945Ala details p.Thr945Cys details p.Thr945Arg details p.Thr945Glu details p.Gln946Ala details p.Gln946Cys details p.Gln946Arg details p.Ala947Leu details p.Ala947Cys details p.Ala947Val details	D D ? N N ? N D ? D D ? D D ? N D ? D D ? N D ? N N ? D D ? D D ? N N ? N N ? N N ? D N ? N N ? D D ? D D ? D D ? N D ? D D ? N D ? N D ? D D ? D D ? D D ? N D ? N D ? N N ? N N ? N D ? N N ? N D ? D D ? N D ? N N ? D N ? D N ? D N ? D D ? D D ? D D ? D D ? N N ? D D ?
ABCB11	p.Gly327Glu details p.Trp330* details p.Trp330Arg details p.Gly982Arg details	D D ? - - ? D D ? D D ?
ABCB3	p.Arg373Cys details p.Ala374Asp details p.Ala374Thr details p.Val379Ile details p.Val379Ala details p.Arg380Gln details	D D ? D D ? D D ? N N N N N ? D N ?

The alignment around the queried position:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1042
ABCB4 672

K

N

S

Q

M

C

Q

K

S

L

D

V

E

T

D

G

L

E

A

N

V

P

P

V

S

F

L

K

V

L

K

L

N

K

T

E

W

P

Y

F

711
ABCB1 673

R

G

S

Q

A

Q

D

R

K

L

S

T

K

-

E

A

L

D

E

S

I

P

P

V

S

F

W

R

I

M

K

L

N

L

T

E

W

P

Y

-

711
ABCB1 1281

-

-

-

-

-

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-

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1281
ABCB2 809

-

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809
ABCB3 687

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687
ABCB4 1287

-

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-

1287
ABCB5 813

-

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813
ABCB6 843

-

-

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843
ABCB7 753

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753
ABCB8 736

-

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736
ABCB9 767

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767
ABCB10 739

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739
ABCB11 716

D

H

K

S

T

Y

E

E

D

R

K

D

K

D

I

P

V

Q

E

E

V

E

P

A

P

V

R

R

I

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A

P

E

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P

Y

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755
ABCB11 1322

-

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1322

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