Mutations at homologous positions to ABCC2 p.Lys953
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCC2 |
p.Lys953Arg
|
N
N
?
|
ABCC7 |
p.Asp835*
p.Asp835Ala
p.Asp835Arg
|
-
-
?
N
D
?
N
D
?
|
Mutations +/- 5 a.a. around the position:
ABCC1 |
p.Ala953Cys
|
N
D
?
|
ABCC7 |
p.Lys830*
p.Glu831*
p.Glu831Ala
p.Cys832Ser
p.Cys832Ala
p.Phe833Leu
p.Phe834Leu
p.Asp836*
p.Asp836Tyr
p.Asp836Ala
p.Asp836Cys
p.Asp836Arg
p.Met837*
p.Met837Thr
p.Glu838Ala
p.Glu838Arg
p.Ile840Thr
|
-
-
-
-
D
N
N
D
N
N
?
N
N
?
D
N
?
N
N
?
-
-
?
N
N
N
N
?
N
D
?
D
N
?
-
-
?
N
N
?
N
N
?
N
N
?
N
N
?
|
The alignment around the queried position:
ABCC2 922
R
H
L
K
S
-
-
-
-
-
-
-
-
R
N
S
L
K
T
N
V
N
S
L
K
E
D
E
E
L
V
K
G
Q
K
L
I
K
E
F
I
E
T
G
V
K
F
S
I
Y
L
E
Y
L
A
I
G
-
L
F
S
I
F
I
L
A
F
V
M
N
S
V
A
992
ABCC1 923
D
I
S
R
-
-
-
-
-
-
-
-
-
-
-
-
-
H
H
N
S
T
A
E
L
Q
K
A
E
A
K
K
E
E
T
W
K
L
M
E
A
D
K
Q
T
G
Q
V
L
S
V
Y
W
D
Y
M
K
A
I
G
-
L
F
I
S
F
L
S
I
F
L
F
M
N
H
V
S
988
ABCC3 916
G
Q
G
R
-
-
-
-
-
-
-
-
V
P
R
H
L
G
P
S
E
K
V
Q
V
T
E
A
K
A
D
G
-
-
A
L
T
Q
E
E
K
A
A
I
G
T
V
E
L
S
V
F
W
D
Y
A
K
A
V
G
-
L
C
T
T
L
A
I
C
L
L
Y
V
G
Q
S
A
A
984
ABCC4 663
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
S
R
S
L
K
D
G
A
L
E
S
D
T
E
N
V
P
V
T
L
S
E
E
N
R
S
E
G
K
V
G
F
Q
A
Y
K
N
Y
F
R
A
G
A
H
W
I
V
F
I
F
L
I
L
L
N
T
A
A
Q
V
A
727
ABCC5 809
D
K
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
P
K
T
G
S
V
K
K
E
K
A
V
K
P
E
E
G
Q
L
V
Q
L
E
E
K
G
Q
G
S
V
P
W
S
V
Y
G
V
Y
I
Q
A
A
G
G
P
L
A
F
L
V
I
M
A
L
F
M
L
N
V
G
S
872
ABCC6 898
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
R
T
T
S
E
A
Q
T
E
V
P
L
D
D
P
D
R
A
G
W
P
A
G
K
D
S
I
Q
Y
G
R
V
K
A
T
V
H
L
A
L
R
A
V
G
-
P
C
L
Y
L
F
L
C
Q
Q
V
A
960
ABCC7 796
L
A
Q
N
L
T
E
L
Y
L
E
T
L
E
I
S
E
I
N
L
S
A
V
T
T
N
T
L
H
K
S
I
F
V
I
W
L
V
I
F
L
A
V
A
875
ABCC8 964
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
L
L
Q
D
E
E
E
E
E
E
E
A
A
E
S
E
E
D
D
N
L
S
S
M
L
H
Q
R
A
E
I
P
W
A
A
K
Y
L
S
S
A
G
-
I
L
L
L
S
L
V
F
S
Q
L
L
K
M
V
1025
ABCC9 946
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
K
A
Q
M
E
D
E
D
E
E
E
E
E
E
D
E
D
D
N
M
S
T
V
M
R
L
R
T
K
M
P
W
K
T
C
W
R
Y
L
T
S
G
G
-
F
F
L
L
I
L
M
I
F
S
K
L
L
K
H
S
V
1007
ABCC10 870
L
H
V
Y
Q
-
-
-
-
-
-
-
-
A
Y
W
K
A
V
G
Q
G
L
A
L
A
I
L
F
S
L
L
L
M
Q
A
T
R
N
A
A
D
W
W
L
S
H
W
I
S
Q
L
K
A
E
N
S
S
Q
E
A
Q
-
P
S
T
S
P
A
S
M
G
L
F
S
P
Q
L
L
L
940
ABCC11 756
S
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
L
A
T
S
L
E
E
S
L
N
G
N
A
V
P
E
H
Q
L
T
Q
E
E
E
M
E
E
G
S
L
S
W
R
V
Y
H
H
Y
I
Q
A
A
G
G
Y
M
V
S
C
I
I
F
F
F
V
V
L
I
V
F
L
819
ABCC12 745
D
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
K
E
S
E
T
G
S
E
F
V
D
T
K
V
P
E
H
Q
L
I
Q
T
E
S
P
Q
E
G
T
V
T
W
K
T
Y
H
T
Y
I
K
A
G
G
Y
L
L
S
L
F
T
V
F
L
F
L
L
M
I
G
S
808