Mutations at homologous positions to ABCB4 p.Tyr949

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

		SNAP2 PROVEAN Effect_dbs
ABCB4	p.Tyr949Ala details p.Tyr949Phe details p.Tyr949Gln details	D D ? N N ? D D ?
ABCB1	p.Tyr307Cys details p.Tyr307Phe details p.Tyr307Arg details p.Tyr950Ala details p.Tyr950Cys details p.Tyr950Phe details p.Tyr950Arg details	D D ? N N ? D D ? D D ? D D ? N N ? D D ?

Mutations +/- 5 a.a. around the position:

ABCB4	p.Gln945* details p.Ala946Thr details p.Phe947Ala details p.Met948Ile details p.Ala953Asp details p.Gly954Ser details	- - ? N D ? N N ? N N ? D D ? N N ?
ABCB1	p.Ala302Cys details p.Ala302Arg details p.Phe303Cys details p.Phe303Arg details p.Leu304Cys details p.Ile306Cys details p.Ile306Glu details p.Ile306Arg details p.Ile306Ala details p.Tyr310Phe details p.Thr945Ala details p.Thr945Cys details p.Thr945Arg details p.Thr945Glu details p.Gln946Ala details p.Gln946Cys details p.Gln946Arg details p.Ala947Leu details p.Ala947Cys details p.Ala947Val details p.Met948Ala details p.Met948Ile details p.Met949Ala details p.Met949Cys details p.Met949Arg details p.Phe951Ala details p.Ser952Ala details p.Ser952Arg details p.Tyr953Ala details p.Tyr953Cys details p.Tyr953Phe details p.Tyr953Arg details p.Ala954Leu details p.Ala954Cys details p.Gly955Val details	N N ? D D ? D D ? D D ? N D ? D D ? D D ? D D ? D D ? N D ? N N ? D N ? D N ? D N ? D D ? D D ? D D ? D D ? N N ? D D ? N D ? N N ? D D ? D D ? D D ? N D ? N N ? D D ? D D ? D D ? N D ? D D ? D D ? N D ? N D ?
ABCB11	p.Trp330* details p.Trp330Arg details p.Cys336Ser details p.Tyr337His details p.Leu339Val details	- - ? D D ? N N ? D D ? N N ?
ABCB3	p.Arg380Gln details	D N ?

The alignment around the queried position:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1042
ABCB4 672

K

N

S

Q

M

C

Q

K

S

L

D

V

E

T

D

G

L

E

A

N

V

P

P

V

S

F

L

K

V

L

K

L

N

K

T

E

W

P

Y

F

711
ABCB1 673

R

G

S

Q

A

Q

D

R

K

L

S

T

K

-

E

A

L

D

E

S

I

P

P

V

S

F

W

R

I

M

K

L

N

L

T

E

W

P

Y

-

711
ABCB1 1281

-

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-

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1281
ABCB2 809

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809
ABCB3 687

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687
ABCB4 1287

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1287
ABCB5 813

-

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813
ABCB6 843

-

-

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843
ABCB7 753

-

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753
ABCB8 736

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736
ABCB9 767

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767
ABCB10 739

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739
ABCB11 716

D

H

K

S

T

Y

E

E

D

R

K

D

K

D

I

P

V

Q

E

E

V

E

P

A

P

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755
ABCB11 1322

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1322

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