Mutations at homologous positions to ABCC8 p.Ile60
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Ile60Gly
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC1 |
p.Asp61Glu
|
N
N
?
|
| ABCC6 |
p.Gly61Asp
p.Tyr62His
|
D
D
D
D
D
?
|
| ABCC7 |
p.Met1Val
p.Arg3Trp
p.Pro5Leu
|
N
N
D
D
D
?
D
D
D
|
| ABCC9 |
p.His60Tyr
|
D
N
D
|
The alignment around the queried position:
ABCC8 21
L
G
V
D
N
V
V
F
L
L
F
I
T
F
I
L
W
G
S
S
S
K
V
H
H
H
S
T
W
L
H
F
-
H
L
W
I
L
T
F
M
L
L
F
L
C
E
L
S
G
V
99
ABCC1 20
T
W
S
N
P
D
F
T
F
Q
T
V
L
V
V
F
Y
L
A
F
Y
F
L
Y
L
S
R
H
R
G
Y
I
Q
M
T
L
K
K
A
L
G
F
L
I
V
A
L
F
Y
E
R
R
G
99
ABCC2 19
-
-
-
-
-
E
A
D
P
L
C
F
Q
T
V
L
V
W
I
P
L
G
L
W
L
L
A
P
W
Q
L
L
H
V
Y
K
S
R
T
K
R
S
S
T
T
K
L
Y
L
A
K
Q
V
F
V
G
F
L
L
I
L
A
I
E
L
A
L
V
L
T
E
D
S
-
G
92
ABCC3 19
L
S
V
H
T
E
N
P
D
L
T
P
C
F
Q
N
S
L
L
A
W
V
P
C
I
Y
L
W
V
A
L
P
C
Y
L
L
Y
L
R
H
H
C
R
G
Y
I
I
L
S
L
S
K
L
K
M
V
L
G
V
L
L
W
C
V
S
W
A
D
L
F
Y
S
F
H
G
L
V
H
G
98
ABCC4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC5 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
K
D
I
D
I
G
K
E
Y
I
I
P
S
P
G
Y
R
S
V
R
R
T
S
T
S
G
T
H
R
D
R
E
D
S
K
F
R
R
T
R
L
E
C
46
ABCC6 18
E
P
E
P
A
A
T
S
L
L
S
L
C
F
L
R
T
A
G
V
V
P
M
Y
L
W
V
L
G
P
I
Y
L
L
F
I
H
H
H
G
R
L
R
M
S
P
L
F
K
A
K
M
V
L
G
F
A
L
I
V
L
C
T
S
S
V
A
V
A
L
W
K
I
Q
Q
G
97
ABCC7 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
ABCC9 19
V
L
Q
N
S
F
V
D
A
L
N
L
V
P
H
V
F
L
L
I
T
F
P
I
L
F
I
G
W
G
S
S
S
K
V
Q
I
H
N
T
W
L
H
F
P
-
G
N
L
R
W
I
L
T
F
A
L
L
F
V
H
V
C
E
I
A
E
G
I
V
S
D
S
R
R
97
ABCC10 19
-
-
-
L
W
E
G
D
T
T
G
H
C
F
T
Q
L
V
L
S
A
L
P
H
A
L
L
A
V
L
S
A
C
Y
L
G
T
P
R
S
P
D
-
Y
I
L
P
C
S
P
G
W
R
L
R
L
A
A
S
F
L
L
S
V
F
P
L
L
D
L
L
P
V
A
L
P
P
G
A
G
94
ABCC11 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
T
R
K
R
T
Y
W
V
P
N
S
S
G
G
L
V
N
G
I
D
I
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
D
M
V
S
29
ABCC12 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
V
G
3