ABCC5 p.Ile1251Val
| Predicted by SNAP2: | A: D (71%), C: D (53%), D: D (91%), E: D (85%), F: D (71%), G: D (85%), H: D (80%), K: D (85%), L: D (53%), M: N (57%), N: D (85%), P: D (91%), Q: D (80%), R: D (85%), S: D (75%), T: D (75%), V: N (87%), W: D (80%), Y: D (80%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, G: D, H: D, K: D, L: N, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: N, W: D, Y: D, |
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[hide] Multidrug resistance in the chronic lymphoprolifer... Leuk Lymphoma. 2010 Oct;51(10):1793-804. Drain S, Catherwood MA, Alexander HD
Multidrug resistance in the chronic lymphoproliferative disorders.
Leuk Lymphoma. 2010 Oct;51(10):1793-804., [PMID:20615085]
Abstract [show]
Multidrug resistance (MDR) is a phenomenon in malignancy whereby tumor cells generate mechanisms to resist cytotoxic treatments. Several such mechanisms have been identified. However, to date the most significant research on MDR has involved the adenosine triphosphate binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp) and multidrug resistance associated protein (MRP). These proteins have natural functions involving substrate transport in normal cells but are detrimental to treatment when expressed in the membrane of tumor cells. It remains unclear whether ABC mediated MDR functions primarily through protein up-regulation or via a relevant signaling mechanism, or is simply due to selective pressure on an already resistant tumor cell subpopulation. Here we present an overview of MDR in the chronic lymphoproliferative disorders (CLPDs), in particular that attributed to the ABC transporter protein family.
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No. Sentence Comment
209 Exon rs designation Allele change Synonymous/ non-synonymous Residue effect 29 rs2235051 G-C Synonymous Gly-1249-Gly 29 rs28364274 A-G Non-synonymous Ile-1251-Val 29 rs35721439 A-C Non-synonymous Lys-1256-Thr *Most SNPs have been investigated as far as the amino acid level.
X
ABCC5 p.Ile1251Val 20615085:209:150
status: NEW