Mutations at homologous positions to ABCB1 p.Tyr1087

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

		SNAP2 PROVEAN Effect_dbs
ABCB1	p.Tyr444Arg details p.Tyr444* details p.Tyr444Phe details p.Tyr444Glu details p.Tyr444Leu details p.Tyr444Ala details p.Tyr1087Cys details p.Tyr1087Ala details p.Tyr1087Leu details p.Tyr1087Phe details p.Tyr1087Asp details p.Tyr1087Pro details p.Tyr1087Arg details	D D ? - - ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ?
ABCB11	p.Tyr472* details p.Tyr472Cys details	- - ? D D ?

Mutations +/- 5 a.a. around the position:

ABCB1	p.Leu439Cys details p.Leu443Cys details p.Leu443Val details p.Leu443* details p.Leu443Ala details p.Leu443Arg details p.Leu443Ser details p.Leu443Phe details p.Glu448Lys details p.Gly449Ala details p.Arg1085Cys details p.Phe1086Cys details p.Phe1086Ala details p.Phe1086Asp details p.Phe1086Arg details p.Phe1086Trp details p.Phe1086Leu details p.Phe1086Tyr details p.Phe1086* details p.Asp1088Cys details p.Asp1088Asn details p.Gly1092Glu details	D D ? N D ? N N ? - - ? D D ? D D ? D D ? N N ? N D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? D D ? N D ? - - ? D D ? D D ? D D ?
ABCB11	p.Arg470Gln details p.Arg470* details p.Arg1128His details p.Arg1128Cys details p.Asp1131Val details	D D ? - - ? D D ? D D ? D D ?
ABCB4	p.Arg444Glu details p.Glu450Gly details p.Leu1082Gln details p.Leu1082Cys details	D D ? D D ? D D ? N D ?
ABCB7	p.Glu523Gln details	N N ?

The alignment around the queried position:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1042
ABCB1 673

R

G

S

Q

A

Q

D

R

K

L

S

T

K

-

E

A

L

D

E

S

I

P

P

V

S

F

W

R

I

M

K

L

N

L

T

E

W

P

Y

-

711
ABCB1 1281

-

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-

-

-

-

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1281
ABCB2 809

-

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809
ABCB3 687

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-

687
ABCB4 672

K

N

S

Q

M

C

Q

K

S

L

D

V

E

T

D

G

L

E

A

N

V

P

P

V

S

F

L

K

V

L

K

L

N

K

T

E

W

P

Y

F

711
ABCB4 1287

-

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1287
ABCB5 813

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813
ABCB6 843

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843
ABCB7 753

-

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753
ABCB8 736

-

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736
ABCB9 767

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767
ABCB10 739

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739
ABCB11 716

D

H

K

S

T

Y

E

E

D

R

K

D

K

D

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P

V

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E

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755
ABCB11 1322

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1322

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