ABCMdb

PMID: 23760269

Billet A, Luo Y, Balghi H, Hanrahan JW
Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR).
J Biol Chem. 2013 Jul 26;288(30):21815-23. doi: 10.1074/jbc.M113.479360. Epub 2013 Jun 11., [PubMed]

Sentences

No. Mutations Sentence Comment

102 ABCC7 p.Ser660Ala ABCC7 p.Ser737Ala ABCC7 p.Ser795Ala ABCC7 p.Ser813Ala ABCC7 p.Ser686Ala ABCC7 p.Ser790Ala ABCC7 p.Ser768Ala ABCC7 p.Ser712Ala ABCC7 p.Ser700Ala ABCC7 p.Ser422Ala ABCC7 p.Ser670Ala ABCC7 p.Ser753Ala ABCC7 p.Thr788Ala ABCC7 p.Thr690Ala ABCC7 p.Thr787Ala Carbachol Stimulates CFTR through PKA and Non-PKA Signaling Pathways-To explore PKA-independent regulation of CFTR without using inhibitors that might have confounding effects on other pathways, we studied the activation of 15SA-CFTR (S422A/S660A/S670A/S686A/T690A/S700A/S712A/ S737A/S753A/S768A/T787A/T788A/S790A/S795A/S813A). Login to comment 130 ABCC7 p.Ser686Ala ABCC7 p.Ser790Ala ABCC7 p.Thr791Ala ABCC7 p.Ser809Ala ABCC7 p.Thr604Ala ABCC7 p.Ser707Ala ABCC7 p.Thr582Ala ABCC7 p.Ser641Ala To study PKC regulation without using inhibitors that could perturb other signaling pathways, we used BHK cells expressing 9CA-CFTR, a mutant that lacks all 9 PKC consensus sites in the RD and NBD1 regulatory extension (T582A/T604A/S641A/T682/S686A/S707A/ S790A/T791A/S809A) (13). Login to comment