ABCC1 p.Gly771Asp

Predicted by SNAP2: A: D (85%), C: D (80%), D: D (95%), E: D (95%), F: D (95%), H: D (95%), I: D (91%), K: D (95%), L: D (95%), M: D (91%), N: D (91%), P: D (95%), Q: D (91%), R: D (95%), S: D (85%), T: D (91%), V: D (91%), W: D (95%), Y: D (95%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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Publications
[hide] Szentpetery Z, Sarkadi B, Bakos E, Varadi A
Functional studies on the MRP1 multidrug transporter: characterization of ABC-signature mutant variants.
Anticancer Res. 2004 Mar-Apr;24(2A):449-55., [PMID:15152943]

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[hide] Ren XQ, Furukawa T, Haraguchi M, Sumizawa T, Aoki S, Kobayashi M, Akiyama S
Function of the ABC signature sequences in the human multidrug resistance protein 1.
Mol Pharmacol. 2004 Jun;65(6):1536-42., [PMID:15155846]

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[hide] Szentpetery Z, Kern A, Liliom K, Sarkadi B, Varadi A, Bakos E
The role of the conserved glycines of ATP-binding cassette signature motifs of MRP1 in the communication between the substrate-binding site and the catalytic centers.
J Biol Chem. 2004 Oct 1;279(40):41670-8. Epub 2004 Jul 12., 2004-10-01 [PMID:15252017]

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[hide] Zhao Q, Chang XB
Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1.
J Biol Chem. 2004 Nov 19;279(47):48505-12. Epub 2004 Sep 7., 2004-11-19 [PMID:15355964]

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[hide] Frelet A, Klein M
Insight in eukaryotic ABC transporter function by mutation analysis.
FEBS Lett. 2006 Feb 13;580(4):1064-84. Epub 2006 Jan 19., 2006-02-13 [PMID:16442101]

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[hide] Chang XB
A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1.
Cancer Metastasis Rev. 2007 Mar;26(1):15-37., [PMID:17295059]

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[hide] Chang XB
Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.
Methods Mol Biol. 2010;596:223-49., [PMID:19949927]

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[hide] Long Y, Li Q, Cui Z
Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish.
Mol Biol Rep. 2011 Mar;38(3):1703-11. Epub 2010 Sep 15., [PMID:20842442]

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[hide] Heredi-Szabo K, Kis E, Molnar E, Gyorfi A, Krajcsi P
Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4.
J Biomol Screen. 2008 Apr;13(4):295-301. Epub 2008 Mar 18., [PMID:18349419]

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[hide] Fulop K, Jiang Q, Wetering KV, Pomozi V, Szabo PT, Aranyi T, Sarkadi B, Borst P, Uitto J, Varadi A
ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum.
Biochem Biophys Res Commun. 2011 Nov 25;415(3):468-71. Epub 2011 Oct 28., [PMID:22056557]

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