PMID: 20842442

Long Y, Li Q, Cui Z
Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish.
Mol Biol Rep. 2011 Mar;38(3):1703-11. Epub 2010 Sep 15., [PubMed]
Sentences
No. Mutations Sentence Comment
142 ABCC1 p.Gly1433Asp
X
ABCC1 p.Gly1433Asp 20842442:142:156
status: NEW
view ABCC1 p.Gly1433Asp details
ABCC1 p.Gly771Asp
X
ABCC1 p.Gly771Asp 20842442:142:147
status: NEW
view ABCC1 p.Gly771Asp details
 Overexpression of ABCC1-G1420D sensitizes zebrafish embryos to heavy metals It has been shown that a mutation in the ABC signature of human ABCC1 (G771D or G1433D) abolished its ATP hydrolysis and transport function without effects on the substrates binding activity [26]. Login to comment