Mutations at homologous positions to ABCC8 p.Gln1060
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Gln1060Pro
|
D
N
?
|
| ABCC7 |
p.Ser912Leu
p.Ser912*
|
D
N
N
-
-
|
Mutations +/- 5 a.a. around the position:
| ABCC2 |
p.Gln1019His
p.Arg1023Ala
p.Val1024Ala
|
N
N
?
D
D
?
N
D
?
|
| ABCC4 |
p.Glu757Lys
|
D
N
?
|
| ABCC6 |
p.Gln981His
|
D
D
D
|
| ABCC7 |
p.Thr908Asn
p.Thr908Ser
p.Ser909Cys
p.Ser909Ile
p.Thr910Asn
p.Ser911Arg
p.Tyr913Cys
p.Tyr913Ser
p.Tyr913*
p.Tyr914*
p.Tyr917Cys
|
N
N
N
N
?
D
N
?
N
N
?
N
N
?
D
N
?
D
D
D
D
D
?
-
-
-
-
?
D
D
|
The alignment around the queried position:
ABCC8 1026
L
V
A
I
D
Y
W
L
A
K
W
T
D
S
A
L
T
L
T
P
A
A
R
-
-
-
-
-
N
C
S
L
S
Q
E
C
T
L
D
T
V
Y
A
M
V
F
T
V
L
C
S
L
G
I
V
L
C
L
V
T
S
V
T
V
E
W
T
G
L
K
V
A
K
R
L
H
R
S
L
1100
ABCC1 989
L
A
S
N
Y
W
L
S
L
W
T
D
D
I
-
-
-
-
-
-
-
-
-
-
-
-
V
G
T
Q
E
H
-
-
-
-
T
K
V
R
L
S
V
Y
G
L
G
I
S
Q
G
I
A
V
F
G
Y
M
A
V
S
I
G
G
I
L
A
S
L
V
D
L
1052
ABCC2 993
F
I
G
S
N
L
W
L
S
A
W
T
S
D
S
K
-
-
-
-
-
-
-
-
-
-
-
-
I
F
N
S
T
D
Y
P
A
S
R
D
M
G
V
Y
G
A
L
G
L
A
Q
G
F
V
F
I
A
F
W
S
A
F
G
F
V
H
A
S
N
I
L
H
Q
L
1060
ABCC3 985
A
I
G
A
N
V
W
L
A
W
T
N
D
A
M
-
-
-
-
-
-
-
-
-
-
-
-
A
D
S
R
Q
N
N
-
-
-
-
T
S
L
R
L
G
V
Y
A
A
L
G
I
L
Q
G
F
L
V
M
L
A
A
M
A
M
A
A
G
G
I
Q
A
A
R
V
L
H
Q
A
L
1048
ABCC4 728
Y
V
L
Q
D
W
W
L
S
Y
W
A
N
K
Q
S
L
N
-
-
-
-
-
-
V
T
V
N
G
G
G
N
V
T
K
L
D
L
N
W
Y
L
G
I
Y
S
G
L
T
V
A
T
L
F
G
I
A
R
S
L
L
V
F
Y
V
L
V
N
S
Q
L
N
K
801
ABCC5 873
T
A
F
S
T
W
W
L
S
Y
W
I
K
Q
G
S
G
N
T
T
V
T
R
G
N
E
T
S
V
S
D
-
S
M
K
D
N
P
H
M
Q
Y
Y
A
S
I
Y
A
L
S
M
A
V
M
L
I
L
K
A
I
R
G
V
V
F
V
K
G
T
L
R
A
S
S
R
L
H
D
E
L
951
ABCC6 961
S
F
C
G
Y
W
L
S
L
A
D
D
P
A
-
-
-
-
-
-
-
-
-
-
-
-
V
G
G
Q
T
Q
-
-
-
-
A
A
L
R
G
G
I
F
L
L
G
C
L
Q
A
I
G
L
F
A
S
M
A
A
V
L
G
G
A
R
A
S
R
L
L
F
Q
R
L
1024
ABCC7 876
A
L
V
V
L
L
L
G
N
P
L
G
H
S
-
-
-
N
S
A
V
I
I
V
F
V
T
A
M
G
F
G
L
L
T
L
I
T
V
I
L
952
ABCC9 1008
I
V
A
I
D
Y
W
L
A
T
W
T
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
Y
S
I
N
N
T
G
K
A
D
Q
T
Y
Y
V
A
G
S
I
L
G
A
G
I
F
L
C
L
V
T
L
T
V
E
W
M
G
L
T
A
A
K
N
L
H
H
N
L
1072
ABCC10 941
F
S
P
G
N
L
Y
I
P
V
F
P
L
P
K
A
-
-
-
-
-
-
-
-
-
-
-
-
A
P
N
G
S
S
D
-
-
-
-
I
R
F
Y
L
T
V
Y
A
T
I
A
G
V
N
S
L
C
T
L
L
R
A
V
L
F
A
A
G
T
L
Q
A
A
A
L
H
R
R
L
1004
ABCC11 820
T
I
F
S
F
W
W
L
S
Y
W
L
E
Q
G
S
G
T
S
S
R
E
S
G
T
M
A
D
L
G
N
I
A
D
N
P
Q
L
S
F
Y
Q
L
V
Y
G
L
N
A
L
L
L
I
C
V
G
V
C
S
S
G
I
F
T
K
V
T
R
K
A
S
T
A
L
H
N
K
L
899
ABCC12 809
A
A
F
S
N
W
W
L
G
L
W
L
D
K
G
S
R
M
T
C
G
P
Q
G
N
R
T
M
C
E
V
G
A
V
L
A
D
I
G
Q
H
V
Y
Q
W
V
Y
T
A
S
M
V
F
M
L
V
F
G
V
T
K
G
F
V
F
T
K
T
T
L
M
A
S
S
S
L
H
D
T
V
888