Mutations at homologous positions to ABCC1 p.Val105
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC1 |
p.Val105Ile
|
N
N
?
|
| ABCC3 |
p.Val104Met
|
D
N
?
|
| ABCC8 |
p.His105Pro
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC1 |
p.Leu102Trp
p.Pro104Ala
p.Val108Ile
p.Pro110Ala
|
N
N
?
N
D
?
N
N
?
N
D
?
|
| ABCC2 |
p.Arg100*
p.Arg100Gln
|
-
-
?
N
N
?
|
| ABCC3 |
p.Arg99Gln
|
N
N
?
|
| ABCC7 |
p.Met1Val
p.Arg3Trp
p.Pro5Leu
|
N
N
D
D
D
?
D
D
D
|
| ABCC8 |
p.Glu100Lys
p.Glu100*
|
N
N
?
-
-
?
|
The alignment around the queried position:
ABCC1 66
Q
M
T
L
K
K
A
L
G
F
L
I
V
A
L
F
Y
E
R
R
G
I
F
A
F
L
S
-
-
-
T
L
L
G
I
T
M
L
L
A
T
F
L
I
Q
L
E
R
R
K
G
V
Q
-
S
S
G
I
M
L
F
141
ABCC2 60
S
T
T
K
L
Y
L
A
K
Q
V
F
V
G
F
L
L
I
L
A
I
E
L
A
L
V
L
T
E
D
S
-
G
Q
A
T
V
P
A
V
Y
T
-
-
-
N
P
S
L
Y
L
G
T
W
L
L
V
L
L
I
Q
Y
S
W
C
V
Q
K
N
S
W
F
L
S
L
F
135
ABCC3 65
I
L
S
L
S
K
L
K
M
V
L
G
V
L
L
W
C
V
S
W
A
D
L
F
Y
S
F
H
G
L
V
H
G
A
P
A
P
F
F
V
T
-
-
-
P
L
V
V
G
V
T
M
L
L
A
T
L
L
I
Q
Y
E
R
L
Q
G
V
Q
-
S
S
G
V
L
I
I
F
140
ABCC4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
L
P
V
Y
Q
E
V
K
P
N
P
L
Q
D
-
-
-
-
-
-
-
-
16
ABCC5 13
P
S
P
G
Y
R
S
V
R
R
T
S
T
S
G
T
H
R
D
R
E
D
S
K
F
R
R
T
R
L
E
C
Q
D
A
L
E
T
A
A
R
A
-
-
-
-
-
-
-
-
-
-
-
-
-
E
G
L
S
L
D
A
S
M
H
S
Q
L
R
I
L
D
E
E
H
P
K
G
79
ABCC6 64
R
M
S
P
L
F
K
A
K
M
V
L
G
F
A
L
I
V
L
C
T
S
S
V
A
V
A
L
W
K
I
Q
Q
G
T
P
E
A
P
E
F
L
I
H
-
-
-
P
T
V
W
L
T
T
M
S
F
A
V
F
L
I
H
T
R
K
K
V
Q
-
S
S
G
V
L
F
G
Y
139
ABCC7 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Q
S
L
E
K
A
S
-
-
-
-
-
-
-
-
-
-
-
-
11
ABCC8 67
H
F
-
H
L
W
I
L
T
F
M
L
L
F
L
C
E
L
S
G
V
S
H
H
L
L
Y
M
P
-
-
-
A
M
F
M
A
T
V
V
Y
Y
N
I
T
S
N
P
K
I
A
L
L
V
Y
142
ABCC9 65
H
F
P
-
G
N
L
R
W
I
L
T
F
A
L
L
F
V
H
V
C
E
I
A
E
G
I
V
S
D
S
R
R
E
S
R
H
L
H
L
F
M
P
-
-
-
A
V
M
G
F
V
A
T
T
T
S
I
V
Y
Y
H
N
I
E
T
S
N
F
P
K
L
L
L
A
L
F
L
Y
140
ABCC10 61
P
C
S
P
G
W
R
L
R
L
A
A
S
F
L
L
S
V
F
P
L
L
D
L
L
P
V
A
L
P
P
G
A
G
P
G
P
I
G
L
E
V
L
A
G
C
V
A
A
V
A
W
I
S
H
S
L
A
L
W
V
L
A
H
S
P
H
H
S
R
G
P
L
A
L
L
V
A
140
ABCC11 10
P
N
S
S
G
G
L
V
N
G
I
D
I
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
D
M
V
S
G
L
I
Y
K
T
Y
T
L
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
D
G
P
W
S
Q
Q
E
R
N
P
E
A
P
G
R
A
A
V
P
P
W
G
62
ABCC12 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
V
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
G
P
Y
L
I
S
D
L
D
Q
R
G
R
R
R
S
F
A
-
-
-
E
23