ABCMdb

ABCC2 p.Ala80Gly

Predicted by SNAP2:	C: N (93%), D: D (53%), E: N (53%), F: N (72%), G: N (72%), H: N (57%), I: N (93%), K: D (53%), L: N (82%), M: N (82%), N: N (66%), P: N (61%), Q: N (66%), R: D (53%), S: N (87%), T: N (87%), V: N (97%), W: N (53%), Y: N (57%),
Predicted by PROVEAN:	C: N, D: N, E: N, F: N, G: N, H: N, I: N, K: N, L: N, M: N, N: N, P: N, Q: N, R: N, S: N, T: N, V: N, W: N, Y: N,

[switch to compact view]
Comments [show]

None has been submitted yet.

Publications
[hide] Influence of pre-hydration and pharmacogenetics on... Int J Hematol. 2013 Dec;98(6):702-7. doi: 10.1007/s12185-013-1464-z. Epub 2013 Nov 16. Yanagimachi M, Goto H, Kaneko T, Naruto T, Sasaki K, Takeuchi M, Tanoshima R, Kato H, Yokosuka T, Kajiwara R, Fujii H, Tanaka F, Goto S, Takahashi H, Mori M, Kai S, Yokota S
Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy.
Int J Hematol. 2013 Dec;98(6):702-7. doi: 10.1007/s12185-013-1464-z. Epub 2013 Nov 16., [PMID:24241962]

Abstract [show]
High-dose methotrexate therapy (HD-MTX) has been well established for the treatment of childhood acute lymphoblastic leukemia (ALL). The aims of this study were to investigate whether clinical and pharmacogenetic factors influence plasma MTX concentration and renal dysfunction in patients treated with HD-MTX. In a total of 127 courses of HD-MTX in 51 patients with childhood ALL, influence of clinical and pharmacogenetic factors on plasma MTX concentration and HD-MTX-related renal dysfunction was evaluated. Clinical factors included age, gender, duration of HD-MTX continuous-infusion and duration of pre-hydration before HD-MTX. Pharmacogenetic factors included 5 gene polymorphisms within the MTX pathway genes, namely, SLC19A1, MTHFR, ABCC2 and ABCG2. Short duration of pre-hydration before HD-MTX is the most important risk factor for prolonged high MTX concentration (p < 0.001, OR 6.40, 95 % CI 2.39-17.16) and renal dysfunction (p = 0.013, OR 3.15, 95 % CI 1.27-7.80). The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. We found the influence of MTHFR C677T polymorphism on prolonged high MTX concentration. We reconfirmed the importance of adequate pre-hydration before HD-MTX to prevent prolonged high MTX concentration and MTX-related renal dysfunction.

Comments [show]

None has been submitted yet.

Sentences [show]
No. Sentence Comment
50 Genotyping for SLC19A1 A80G (rs1051266), ABCG2 C421A (rs2231142), MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131) and ABCC2 C-24T (rs717620) were performed using the TaqMan technique (Applied Biosystems, Foster, CA, USA). Login to comment
52 Custom TaqMan SNP Genotyping Assays was used for SLC19A1 A80G and ABCG2 C421A [24] (see supplementary table 1). Login to comment