Mutations at homologous positions to ABCB4 p.Ala953

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

		SNAP2 PROVEAN Effect_dbs
ABCB4	p.Ala953Asp details	D D ?
ABCB1	p.Ala954Leu details p.Ala954Cys details	D D ? N D ?

Mutations +/- 5 a.a. around the position:

ABCB4	p.Met948Ile details p.Tyr949Ala details p.Tyr949Phe details p.Tyr949Gln details p.Gly954Ser details p.Arg957* details	N N ? D D ? N N ? D D ? N N ? - - D
ABCB1	p.Ile306Cys details p.Ile306Glu details p.Ile306Arg details p.Ile306Ala details p.Tyr307Cys details p.Tyr307Phe details p.Tyr307Arg details p.Tyr310Phe details p.Ala313Gly details p.Phe314Cys details p.Trp315Arg details p.Met949Ala details p.Met949Cys details p.Met949Arg details p.Tyr950Ala details p.Tyr950Cys details p.Tyr950Phe details p.Tyr950Arg details p.Phe951Ala details p.Ser952Ala details p.Ser952Arg details p.Tyr953Ala details p.Tyr953Cys details p.Tyr953Phe details p.Tyr953Arg details p.Gly955Val details p.Cys956Ala details p.Cys956Ser details p.Phe957Ala details p.Phe957Cys details	D D ? D D ? D D ? D D ? D D ? N N ? D D ? N D ? N D ? N D ? D D ? D D ? D D ? D D ? D D ? D D ? N N ? D D ? N D ? N N ? D D ? D D ? D D ? N D ? D D ? N D ? N D ? N D ? N D ? N D ?
ABCB11	p.Cys336Ser details p.Tyr337His details p.Leu339Val details p.Trp342Gly details	N N ? D D ? N N ? D D ?
ABCB3	p.Cys394Val details	N D ?

The alignment around the queried position:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1042
ABCB4 672

K

N

S

Q

M

C

Q

K

S

L

D

V

E

T

D

G

L

E

A

N

V

P

P

V

S

F

L

K

V

L

K

L

N

K

T

E

W

P

Y

F

711
ABCB1 673

R

G

S

Q

A

Q

D

R

K

L

S

T

K

-

E

A

L

D

E

S

I

P

P

V

S

F

W

R

I

M

K

L

N

L

T

E

W

P

Y

-

711
ABCB1 1281

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

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-

1281
ABCB2 809

-

-

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809
ABCB3 687

-

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687
ABCB4 1287

-

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-

-

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1287
ABCB5 813

-

-

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-

-

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-

813
ABCB6 843

-

-

-

-

-

-

-

-

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843
ABCB7 753

-

-

-

-

-

-

-

-

-

-

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-

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753
ABCB8 736

-

-

-

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-

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736
ABCB9 767

-

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767
ABCB10 739

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739
ABCB11 716

D

H

K

S

T

Y

E

E

D

R

K

D

K

D

I

P

V

Q

E

E

V

E

P

A

P

V

R

R

I

L

K

F

S

A

P

E

W

P

Y

M

755
ABCB11 1322

-

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1322

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