Mutations at homologous positions to ABCB3 p.Leu464
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB3 |
p.Leu464Phe
|
N
D
?
|
| ABCB1 |
p.Leu1031Met
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Glu393Cys
p.Pro1028Gln
p.Thr1036Ala
|
D
D
?
N
D
?
N
N
?
|
| ABCB11 |
p.Leu413Trp
p.Arg415Gln
p.Arg415*
p.Ile420Thr
p.Ile1078Thr
|
D
N
?
N
N
?
-
-
?
D
D
?
N
D
?
|
| ABCB4 |
p.Gly392Glu
p.Gly392Lys
p.Glu395Gly
|
D
D
?
D
D
?
D
D
?
|
| ABCB5 |
p.Ala562Arg
|
N
N
?
|
| ABCB6 |
p.Gly588Ser
|
D
D
?
|
The alignment around the queried position:
ABCB3 428
Y
I
Y
G
D
M
L
S
N
V
G
A
A
E
K
V
F
S
Y
M
D
R
Q
P
N
L
P
S
P
G
-
-
T
L
A
P
T
T
-
Q
G
V
V
K
F
Q
D
V
S
F
A
Y
P
N
R
P
D
R
P
V
L
K
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
504
ABCB1 350
I
E
F
A
N
A
R
A
Y
E
I
F
K
I
N
K
S
I
D
S
Y
S
S
G
H
K
P
D
N
-
I
K
G
N
L
F
V
H
R
K
E
V
K
L
K
G
L
N
L
K
Q
S
G
Q
T
V
A
L
V
428
ABCB1 993
A
D
Y
K
A
K
I
S
A
H
I
I
M
I
I
K
P
L
I
D
S
Y
S
T
E
G
L
M
N
T
-
E
G
N
V
F
G
E
V
V
F
T
R
P
D
L
Q
G
L
S
L
E
V
K
Q
L
A
L
V
1071
ABCB2 523
S
I
Y
P
R
V
Q
K
A
V
G
S
S
E
K
I
F
E
Y
L
D
R
T
P
R
C
P
P
S
G
-
-
L
L
T
P
L
H
-
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
D
V
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
599
ABCB4 352
C
I
D
A
A
N
A
R
G
A
Y
V
F
D
I
I
D
N
N
P
K
I
D
S
F
S
E
R
G
H
K
P
D
S
-
I
K
N
L
F
N
D
V
H
F
S
P
S
R
A
N
V
K
I
L
K
G
L
N
L
K
V
Q
S
G
Q
A
L
V
G
430
ABCB4 992
S
F
A
P
D
Y
A
K
A
K
L
S
A
A
H
L
F
M
L
F
E
R
Q
P
L
I
D
S
Y
S
E
E
L
K
P
D
K
-
F
E
G
N
I
T
F
N
E
V
V
F
Y
P
T
A
N
V
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
G
S
1070
ABCB5 528
V
L
A
P
E
Y
S
K
A
K
S
G
A
A
H
L
F
A
L
L
E
K
K
P
N
I
D
S
R
S
Q
E
G
K
P
D
T
-
C
E
G
N
L
E
F
R
E
V
S
F
F
Y
C
R
P
V
F
I
L
R
G
L
S
L
S
I
E
R
G
K
T
V
A
F
V
G
S
606
ABCB6 549
T
Y
Y
R
M
I
T
N
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
A
G
P
L
R
F
Q
-
-
K
R
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
E
-
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
624
ABCB7 429
T
V
Y
R
T
R
Q
A
L
I
D
M
N
T
L
F
T
L
L
K
V
D
T
Q
I
K
D
K
V
M
A
S
P
L
Q
I
T
P
Q
T
A
T
V
A
F
D
N
V
H
F
E
Y
I
E
G
Q
K
-
-
V
L
S
G
I
S
F
E
V
P
A
G
K
K
V
A
I
V
G
G
506
ABCB8 430
V
L
F
G
Q
V
V
R
G
L
S
A
G
A
R
V
F
E
Y
M
A
L
N
P
C
I
P
L
S
G
G
C
C
V
P
K
E
Q
-
L
R
G
S
V
T
F
Q
N
V
C
F
S
Y
P
C
R
P
G
F
E
V
L
K
D
F
T
L
T
L
P
P
G
K
I
V
A
L
V
G
Q
508
ABCB9 464
S
V
Y
S
G
L
M
Q
G
V
G
A
A
E
K
V
F
E
F
I
D
R
Q
P
T
M
V
H
D
G
-
-
S
L
A
P
D
H
-
L
E
G
R
V
D
F
E
N
V
T
F
T
Y
R
T
R
P
H
T
Q
V
L
Q
N
V
S
F
S
L
S
P
G
K
V
T
A
L
V
G
P
540
ABCB10 450
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
528
ABCB11 378
P
C
L
E
F
A
T
G
A
T
S
I
F
E
T
I
D
R
K
P
I
I
D
C
M
S
E
D
Y
K
D
-
I
K
G
E
E
F
N
V
T
F
H
Y
P
S
P
E
V
K
I
L
N
L
N
M
I
K
P
G
E
M
T
A
L
V
P
456
ABCB11 1036
S
Y
T
P
S
A
K
K
I
S
A
A
F
F
Q
L
D
P
P
I
S
V
Y
N
T
A
G
E
K
W
D
N
-
F
Q
G
K
D
F
V
D
K
F
T
Y
P
S
P
D
S
Q
V
L
N
G
L
S
V
S
I
S
P
G
Q
T
L
F
G
1114