ABCB3 p.Leu180Gln
Predicted by SNAP2: | A: D (59%), C: D (53%), D: D (80%), E: D (75%), F: N (53%), G: D (63%), H: D (75%), I: N (61%), K: D (80%), M: N (66%), N: D (75%), P: D (75%), Q: D (71%), R: D (80%), S: D (63%), T: D (63%), V: N (66%), W: D (71%), Y: D (63%), |
Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: N, K: D, M: N, N: D, P: D, Q: D, R: D, S: D, T: D, V: N, W: D, Y: D, |
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[hide] Restriction of self-antigen presentation to cytoly... Eur J Immunol. 1995 Jul;25(7):2019-26. Gournier H, Pascolo S, Siegrist CA, Jehan J, Perarnau B, Garcia Z, Rose T, Neefjes J, Lemonnier FA
Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps.
Eur J Immunol. 1995 Jul;25(7):2019-26., [PMID:7542602]
Abstract [show]
Transport of an immunogenic self-peptide from the second domain of the mouse major histocompatibility complex (MHC) H-2Kd class I molecule is blocked at the TAP1-TAP2 peptide pump level due to its amino acid sequence and is not presented to cytolytic T lymphocytes (CTL). We demonstrate that first, TAP1-TAP2 pumps can restrict antigen presentation by selecting against internal peptide motifs which are not involved in peptide binding to MHC class I molecules. Second, some molecules targeted to the endoplasmic reticulum are processed for MHC class I presentation in the cytosol. Third, some abundantly expressed immunogenic self-peptides are cytosolically sequestered. The advantage for the host, in terms of the peripheral T cell repertoire is that the spared CTL can be used to recognize foreign antigens. It is, however, anticipated that this advantage will be exploited by pathogens to evade immune surveillance by similar strategies.
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No. Sentence Comment
33 H-2Kd molecules were immunoprecipitated as 2.4 Recombinant NP genes Paired synthetic oligonucleotides (Genset, Paris, France) corresponding to the 170-179 A3, Cw3, Kd, mutated Kd L174N, N176K, LlSOQ, mutated Cw3 N174L, K176N, mutated A3 N174L or mutated QIOb L174N peptide sequences (Table 1) were introduced in the NP coding region at the Bgl I1 site of the pTKNP Bgl I1 vector [28] providing the NP-A3, NP-Cw3, NP-Kd, mNP-Kd L174N, mNP-Kd N176K, mNP-Kd L180Q, mNP-Cw3 N174L, mNP-Cw3 K176N, mNP-A3 N174L and mNP-QlOhL174N constructs, which were verified by double-stranded DNA sequencing (Sequenase 7B, USB, Cleveland, OH).
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ABCB3 p.Leu180Gln 7542602:33:455
status: NEW