Mutations at homologous positions to ABCA4 p.Cys764
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA4 |
p.Cys764Tyr
|
D
D
|
Mutations +/- 5 a.a. around the position:
ABCA4 |
p.Ala762Glu
p.Ser765Arg
p.Ser765Asn
p.Gly766Asp
p.Gly766Val
p.Val767Asp
|
D
D
?
D
D
D
N
D
D
?
D
D
?
D
D
|
ABCA12 |
p.Gly1179Arg
|
D
D
D
|
ABCA3 |
p.Gly378Arg
|
D
D
?
|
The alignment around the queried position:
ABCA4 725
H
Y
S
D
P
F
I
L
F
L
F
L
L
A
F
S
T
A
T
I
M
L
F
L
L
S
T
F
F
S
K
A
S
L
A
A
I
Y
F
T
L
Y
L
P
H
I
L
C
F
A
-
-
-
-
Q
D
R
M
T
A
E
L
K
K
A
V
L
S
P
V
800
ABCA1 710
L
P
Y
S
D
P
S
V
V
F
V
F
L
S
V
F
A
V
V
T
I
L
Q
F
L
I
S
T
L
F
S
R
A
N
L
A
A
A
C
G
G
I
I
Y
F
T
L
Y
L
P
Y
V
L
C
V
A
-
-
-
-
W
Q
D
Y
G
F
L
I
F
A
S
L
L
S
P
V
785
ABCA2 777
L
M
H
S
H
V
V
I
I
W
L
F
L
A
V
Y
A
V
A
T
I
M
F
C
F
L
V
S
V
L
Y
S
K
A
K
L
A
S
A
C
G
G
I
I
Y
F
L
S
Y
V
P
Y
M
Y
V
A
I
R
E
E
V
A
H
D
K
I
T
A
F
E
K
C
I
A
S
L
M
S
T
T
856
ABCA3 338
L
S
R
D
P
S
L
V
L
A
F
L
L
C
A
I
S
T
I
S
F
S
F
M
V
S
T
F
F
S
K
A
N
M
A
A
A
F
G
F
L
Y
F
F
T
Y
I
Y
F
F
V
A
P
-
-
-
-
R
Y
N
W
M
T
L
S
Q
K
L
C
S
C
L
L
S
N
V
413
ABCA5 292
P
Q
S
S
S
I
V
I
F
L
L
F
F
L
Y
G
L
S
S
V
F
F
A
L
M
L
T
P
L
F
K
K
S
-
-
-
-
K
H
V
G
I
V
E
F
F
V
T
V
A
F
G
F
I
G
L
-
M
I
I
L
I
E
S
F
P
K
S
L
V
W
L
F
S
P
F
C
H
C
T
366
ABCA6 293
V
M
T
G
F
M
V
I
F
I
L
F
F
L
Y
G
L
S
L
V
A
L
V
F
L
M
S
V
L
L
K
K
A
-
-
-
-
V
L
T
N
L
V
V
F
L
L
T
L
F
W
G
C
L
G
-
-
F
T
V
F
Y
E
Q
L
P
S
S
L
E
W
I
L
N
I
C
S
P
F
A
366
ABCA7 620
L
P
Y
S
H
P
G
V
V
F
L
F
L
A
A
F
A
V
A
T
V
T
Q
S
F
L
L
S
A
F
F
S
R
A
N
L
A
A
A
C
G
G
L
A
Y
F
S
L
Y
L
P
Y
V
L
C
V
A
-
-
-
-
W
R
D
R
L
P
A
G
G
R
V
A
A
S
L
L
S
P
V
695
ABCA8 295
I
L
S
G
F
M
V
V
F
S
L
F
L
L
Y
G
L
S
L
V
A
L
A
F
L
M
S
I
L
V
K
K
S
-
-
-
-
F
L
T
G
L
V
V
F
L
L
T
V
F
W
G
C
L
G
-
-
F
T
S
L
Y
R
H
L
P
A
S
L
E
W
I
L
S
L
L
S
P
F
A
368
ABCA9 296
V
L
T
G
F
V
M
V
F
T
L
F
L
L
Y
G
L
S
L
I
T
L
A
F
L
M
S
V
L
I
K
K
P
-
-
-
-
F
L
T
G
L
V
V
F
L
L
I
V
F
W
G
I
L
G
-
-
F
P
A
L
Y
T
R
L
P
A
F
L
E
W
T
L
C
L
L
S
P
F
A
369
ABCA10 206
F
H
T
G
F
M
V
I
F
T
L
Y
S
L
Y
G
L
S
L
I
A
L
A
F
L
M
S
V
L
I
R
K
P
-
-
-
-
M
L
A
G
L
A
G
F
L
F
T
V
F
W
G
C
L
G
-
-
F
T
V
L
Y
R
Q
L
L
S
L
G
W
V
L
S
L
L
S
P
F
A
279
ABCA12 1139
L
P
K
T
N
G
F
I
L
F
L
Y
F
S
D
Y
S
F
S
V
I
A
M
S
Y
L
I
S
V
F
F
N
N
T
N
I
A
A
L
I
S
L
I
Y
I
I
A
F
F
P
F
I
V
L
V
T
-
-
-
-
V
E
N
E
L
S
Y
V
L
K
V
F
M
S
L
L
S
P
T
1214
ABCA13 3642
F
A
H
S
N
T
F
I
V
F
L
F
L
L
D
F
G
M
S
V
V
M
L
S
Y
L
L
S
A
F
F
S
Q
A
N
T
A
A
L
C
T
S
L
V
Y
M
I
S
F
L
P
Y
I
V
L
L
V
-
-
-
-
L
H
N
Q
L
F
V
N
Q
T
F
L
C
L
L
S
T
T
3717