Mutations at homologous positions to ABCC8 p.Met1289
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC8 |
p.Met1289Thr
p.Met1289Leu
|
D
N
?
D
N
?
|
| ABCC1 |
p.Gln1239Ala
|
D
D
?
|
| ABCC11 |
p.Gln1086Glu
|
D
D
?
|
| ABCC3 |
p.Gln1235Ala
|
D
D
?
|
| ABCC7 |
p.Asn1138Ala
p.Asn1138Cys
|
D
N
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC8 |
p.Thr1285Leu
p.Val1290Gln
|
D
D
?
D
D
?
|
| ABCC1 |
p.Ser1235Ala
p.Tyr1236Phe
p.Tyr1236Trp
p.Ser1237Ala
p.Thr1241Ala
p.Thr1242Ala
p.Thr1242Cys
p.Thr1242Ser
p.Thr1242Asp
p.Thr1242Lys
p.Thr1242Leu
p.Tyr1243Phe
|
D
N
?
D
D
?
D
D
?
N
N
?
D
D
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
D
N
?
|
| ABCC10 |
p.Tyr1190Ala
|
D
D
?
|
| ABCC2 |
p.Asn1244Lys
|
D
N
?
|
| ABCC3 |
p.Ser1231Ala
p.Tyr1232Phe
p.Ser1233Ala
p.Thr1237Ala
p.Thr1237Ser
p.Thr1237Leu
p.Thr1237Gly
|
D
N
?
D
D
?
N
N
?
D
D
?
N
D
?
D
D
?
D
D
?
|
| ABCC7 |
p.Leu1133Cys
p.Thr1134Phe
p.Thr1134Ala
p.Thr1134Glu
p.Thr1134Cys
p.Leu1135Cys
p.Leu1135Ala
p.Ala1136Thr
p.Ala1136Cys
p.Ala1136Ser
p.Met1137Ala
p.Met1137Val
p.Met1137Arg
p.Met1137Cys
p.Met1137Thr
p.Ile1139Val
p.Ile1139Cys
p.Ile1139Ala
p.Met1140Lys
p.Met1140Cys
p.Met1140Ile
p.Met1140Ala
p.Met1140Leu
p.Ser1141Ala
p.Ser1141Lys
p.Ser1141Cys
p.Ser1141Arg
p.Thr1142Ala
p.Thr1142Cys
p.Thr1142Phe
p.Thr1142Ile
p.Leu1143Cys
p.Leu1143Ala
|
D
D
?
D
D
?
N
N
?
D
N
?
D
N
?
N
N
?
N
N
?
N
N
?
D
D
?
N
N
?
D
D
?
N
N
D
D
D
D
?
D
D
?
N
N
D
D
?
D
D
?
D
N
D
N
?
D
N
?
D
N
?
D
N
?
N
N
?
D
N
?
N
N
?
D
N
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
The alignment around the queried position:
ABCC8 1250
M
E
Y
G
C
V
V
I
A
V
T
S
I
S
N
S
L
H
R
E
L
S
A
G
L
V
G
L
G
L
Y
A
L
S
N
Y
L
N
W
M
V
R
N
L
A
D
M
L
Q
L
G
A
V
K
R
I
H
L
L
K
T
E
A
-
-
-
-
-
-
1324
ABCC1 1202
L
V
I
V
L
A
A
L
F
A
V
I
S
H
S
-
-
L
S
G
L
V
G
L
V
L
V
L
L
V
M
S
S
E
M
E
T
N
I
V
A
V
E
R
L
K
E
S
E
T
E
K
E
-
-
-
-
-
-
1274
ABCC2 1210
L
E
L
V
G
N
L
T
V
F
F
S
A
L
M
M
V
I
Y
D
T
-
-
L
S
G
D
T
V
G
F
V
L
S
A
L
N
I
T
Q
T
L
N
L
V
M
T
S
E
I
E
T
N
I
V
A
V
E
R
I
E
T
K
V
E
N
E
-
-
-
-
-
-
1282
ABCC3 1198
G
V
E
F
V
G
N
C
V
V
L
F
A
A
L
F
A
V
I
G
R
S
-
-
L
N
P
G
L
V
G
L
V
L
V
F
A
L
M
I
R
M
M
S
D
L
E
S
N
I
V
A
V
E
R
V
K
E
Y
S
K
T
E
T
E
-
-
-
-
-
-
1270
ABCC4 951
R
L
D
A
I
A
M
F
V
I
I
V
A
F
G
S
L
I
L
A
K
T
-
-
L
D
A
G
Q
V
G
L
A
L
S
Y
A
L
T
L
M
G
M
F
Q
C
V
Q
S
A
E
V
E
N
M
M
I
S
V
E
R
V
I
E
Y
T
D
L
E
K
E
-
-
-
-
-
-
1023
ABCC5 1101
R
L
D
L
I
S
I
A
L
I
T
T
T
G
L
M
I
V
L
M
H
G
Q
-
-
I
P
P
A
Y
A
G
L
A
I
S
Y
A
V
Q
L
T
G
L
F
Q
F
T
V
R
L
A
S
E
T
E
A
R
F
T
S
V
E
R
I
N
H
Y
I
K
T
L
S
L
-
-
-
-
-
-
1173
ABCC6 1174
N
V
E
L
L
G
N
L
V
F
A
A
A
T
C
A
V
L
S
K
A
H
-
-
L
S
A
G
L
V
F
S
V
S
A
A
L
Q
V
T
Q
T
L
Q
W
V
V
N
T
D
E
N
S
I
V
S
V
M
A
T
P
K
-
-
-
-
-
-
1246
ABCC7 1102
I
I
-
-
-
G
S
M
V
V
F
F
I
M
P
T
E
K
P
T
S
1178
ABCC9 1222
R
T
D
Y
L
G
A
C
I
V
L
T
A
S
I
A
S
I
S
G
S
S
N
-
-
-
-
S
G
L
V
L
G
L
L
Y
A
L
T
I
T
N
Y
L
N
W
V
V
R
N
L
A
D
L
E
V
Q
M
G
A
V
K
K
V
N
S
F
L
T
M
E
S
E
-
-
-
-
-
-
1292
ABCC10 1154
R
L
Q
L
M
G
A
A
V
V
S
A
I
A
G
I
A
L
V
Q
H
Q
Q
G
L
A
N
P
G
L
V
G
L
S
L
S
A
L
S
L
T
G
L
L
S
G
L
V
S
S
F
T
Q
T
E
A
M
L
V
S
V
E
R
L
E
E
Y
T
C
D
L
P
Q
-
-
-
-
-
-
1228
ABCC11 1049
R
L
E
I
M
T
N
L
V
T
L
A
V
A
L
F
V
A
F
G
I
S
S
-
-
T
P
Y
S
F
K
V
M
A
V
N
I
V
L
L
A
S
S
F
Q
A
T
A
I
G
L
E
T
E
A
Q
F
T
A
V
E
R
I
L
Q
Y
M
K
M
C
V
S
-
-
-
-
-
-
1121
ABCC12 1028
R
M
D
V
L
M
N
I
L
T
F
T
V
A
L
L
V
T
L
S
F
S
S
-
-
I
S
T
S
S
K
L
S
L
S
Y
I
I
Q
L
S
G
L
L
Q
V
C
V
R
T
G
T
E
T
Q
A
K
F
T
S
V
E
L
L
R
E
Y
I
S
T
C
V
P
-
-
-
-
-
-
1100