Mutations at homologous positions to ABCC7 p.Phe1232
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Phe1232Cys
|
N
N
?
|
| ABCC4 |
p.Ala1063Gly
|
N
N
?
|
| ABCC8 |
p.Ala1366Thr
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Leu1227Ser
p.Glu1228Gly
p.Ile1230Thr
p.Ile1234Val
p.Ile1234Leu
p.Ser1235Arg
p.Ser1235Glu
p.Ser1235Asn
p.Gly1237Ala
p.Gly1237Ser
|
D
D
D
D
?
D
D
?
N
N
D
D
N
D
D
N
N
N
N
?
N
N
?
N
N
?
N
N
?
|
| ABCC2 |
p.Ile1324Ser
|
D
D
?
|
| ABCC3 |
p.Gly1316Ala
|
N
D
?
|
| ABCC4 |
p.Thr1062Cys
|
N
D
?
|
| ABCC6 |
p.Ala1291Thr
|
D
N
D
|
| ABCC8 |
p.Ala1369Ser
|
N
N
N
|
| ABCC9 |
p.Lys1333Leu
|
D
D
?
|
The alignment around the queried position:
ABCC7 1193
I
N
H
K
D
D
P
G
T
K
D
L
T
A
E
G
G
I
N
S
S
P
G
L
R
L
A
R
N
-
E
G
E
I
I
G
1271
ABCC1 1277
-
Q
I
Q
E
T
A
P
P
S
S
W
P
Q
G
R
V
E
N
L
R
E
D
L
D
F
V
L
R
H
I
N
V
T
I
N
G
G
E
V
G
I
V
G
R
T
G
G
S
L
L
G
L
F
R
I
N
E
S
E
G
E
I
I
I
D
G
1355
ABCC2 1285
-
V
D
-
K
R
P
P
D
W
P
S
K
G
I
Q
F
N
N
Y
Q
V
R
Y
P
E
L
D
L
V
L
R
G
I
T
C
D
G
S
M
E
K
I
G
V
V
G
R
T
G
A
G
K
S
S
L
T
N
C
L
F
R
L
A
A
G
G
Q
I
I
I
D
G
1362
ABCC3 1273
-
V
V
E
G
S
R
P
P
E
G
W
P
P
G
E
V
E
F
R
N
Y
S
V
Y
R
G
L
D
L
V
L
R
D
L
S
L
H
V
H
G
E
K
V
G
I
G
R
T
G
A
G
K
S
S
M
T
L
C
L
F
R
I
L
E
A
A
K
G
E
I
I
D
G
1351
ABCC4 1026
E
Y
Q
K
-
-
R
P
P
P
A
W
P
H
E
G
V
I
I
F
D
N
V
N
F
M
Y
S
P
G
G
P
L
V
L
K
H
L
L
I
K
S
Q
E
K
G
I
V
G
R
T
G
A
G
S
S
I
S
A
L
F
R
L
S
E
P
-
E
G
K
I
W
I
D
K
1102
ABCC5 1176
A
R
I
K
N
K
A
P
S
P
D
W
P
Q
E
G
E
V
T
F
E
N
A
E
M
R
Y
R
N
L
P
L
V
L
K
K
V
S
F
T
I
K
P
K
E
K
I
G
I
V
G
R
T
G
S
G
K
S
S
L
G
M
L
F
R
L
V
E
L
S
G
C
K
I
D
G
1255
ABCC6 1249
-
R
L
P
T
C
A
A
Q
P
P
P
Q
G
Q
I
E
F
D
F
G
L
Y
P
E
L
P
L
A
V
Q
G
V
S
F
K
I
H
G
K
V
G
I
R
G
K
S
L
A
S
L
L
L
Q
E
A
A
E
G
I
I
1327
ABCC8 1327
G
L
L
A
P
S
L
I
P
K
N
W
P
D
Q
K
I
Q
I
Q
N
L
S
V
R
Y
D
S
L
K
P
V
L
K
H
V
N
L
I
P
G
K
I
G
I
C
G
T
S
G
S
F
S
L
A
F
V
T
F
E
H
I
I
I
D
G
1406
ABCC9 1295
G
T
M
D
P
S
Q
V
P
E
H
W
P
Q
E
G
E
I
K
I
H
D
L
C
V
R
Y
E
N
N
L
K
P
V
L
K
H
V
A
Y
I
K
P
G
Q
K
V
G
I
C
G
R
T
G
S
G
S
S
L
S
L
A
F
F
R
M
V
D
I
F
D
G
K
I
V
I
D
G
1374
ABCC10 1231
-
G
Q
P
L
Q
L
G
T
G
-
W
L
T
Q
G
G
V
E
F
Q
D
V
V
L
A
Y
R
P
G
L
P
N
A
L
D
G
V
T
F
C
V
Q
P
G
E
K
L
G
I
V
G
R
T
G
S
G
K
S
S
L
L
L
V
L
F
R
L
L
E
P
S
S
G
R
V
L
L
D
G
1308
ABCC11 1124
L
H
M
E
G
T
S
C
P
Q
G
W
P
Q
H
G
E
I
I
F
Q
D
Y
H
M
K
Y
R
D
N
T
P
T
V
L
H
G
I
N
L
T
I
R
G
H
E
V
V
G
V
G
R
T
G
S
G
K
S
S
L
G
M
A
L
F
R
L
V
E
P
M
A
G
R
I
L
I
D
G
1203
ABCC12 1103
H
P
L
K
V
G
T
C
P
K
D
W
P
S
R
G
E
I
T
F
R
D
Y
Q
R
Y
R
D
N
T
P
L
V
L
D
S
L
N
L
N
I
Q
S
G
Q
T
V
G
I
V
G
R
T
G
S
G
K
S
S
L
G
M
A
L
F
R
L
V
E
P
A
S
G
T
I
F
I
D
E
1182