ABCC8 p.Leu1014Phe
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PMID: 21651761
[PubMed]
Antonio-Nkondjio C et al: "Anopheles gambiae distribution and insecticide resistance in the cities of Douala and Yaounde (Cameroon): influence of urban agriculture and pollution."
No.
Sentence
Comment
79
To screen for the presence of the kdr alleles (L1014F and L1014S) conferring resistance to DDT and pyrethroids, DNA extracted from individuals exposed to insecticide was tested using the Hot Ligation Oligonucleotide Assay (HOLA) of Lynd et al [26] and the TaqMan assay [27].
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ABCC8 p.Leu1014Phe 21651761:79:47
status: NEW151 The L1014F allele was prevalent in all samples (Table 4).
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ABCC8 p.Leu1014Phe 21651761:151:4
status: NEW197 gambiae molecular forms Genotypes Kdrw/Kdrw Kdrw/KdrE Kdrw/S S/S Total F(Kdr) P(HW) Douala M form 228 1 170 62 460 0.68 P = 0.002 S form - - 1 - 1 Yaoundé M form 79 0 124 115 318 0.44 P = 0.0003 S form - - 2 - 2 Total 307 1 296 177 781 S, wild type; Kdrw, L1014F substitution « West Africa"; KdrE, L1014S substitution "East Africa", Kdrw/S, heterozygote; P(HW), goodness of fit to Hardy Weinberg Equilibrium (significant if P < 0.05).
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ABCC8 p.Leu1014Phe 21651761:197:261
status: NEW
PMID: 22384107
[PubMed]
Ndiath MO et al: "Resistance to DDT and pyrethroids and increased kdr mutation frequency in An. gambiae after the implementation of permethrin-treated nets in Senegal."
No.
Sentence
Comment
5
Species and molecular forms as well as the presence of L1014F and L1014S kdr mutations were assessed by PCR.
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ABCC8 p.Leu1014Phe 22384107:5:55
status: NEW8 During the longitudinal study, L1014F allelic frequency rose from 2.4% in year before the implementation of LLINs to 4.6% 0-12 months after and 18.7% 13-30 months after.
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ABCC8 p.Leu1014Phe 22384107:8:31
status: NEW22 Molecular identification of L1014F mutation indicated that target site resistance increased after the implementation of LLINs.
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ABCC8 p.Leu1014Phe 22384107:22:28
status: NEW80 Molecular identification and kdr genotyping In the subsample of mosquitoes used for bioassay and in adults sampled by HLC during the longitudinal study, detection of L1014F and L1014S kdr mutations (thereafter identified as kdr-w and kdr-e respectively) was performed by PCR [27,28].
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ABCC8 p.Leu1014Phe 22384107:80:166
status: NEW93 Before the implementation of LLINs, L1014F allelic frequency was low and not different when Figure 1. kdr mutation in An.
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ABCC8 p.Leu1014Phe 22384107:93:36
status: NEW96 gambiae with L1014F homozygote mutation (RR), heterozygote mutation (RS) or wild type (SS) sampled 24-13 months (n = 228) and 12-0 months (n = 99) before the implementation of long lasting insecticide-treated nets (LLINs) in July 2008, 0-12 months (n = 327) and 13-30 months after (n = 582).
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ABCC8 p.Leu1014Phe 22384107:96:13
status: NEW