Mutations at homologous positions to ABCB11 p.Val291
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB11 |
p.Val291Ala
|
N
D
?
|
| ABCB1 |
p.Val264Ser
p.Val907Ile
|
D
D
?
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB11 |
p.Gly295Cys
p.Gly295Arg
p.Gly295Ser
p.Arg948Cys
|
N
D
?
D
D
?
N
D
?
D
D
?
|
| ABCB1 |
p.Ala259Gln
p.Ala259Leu
p.Ala259Cys
p.Ala260Leu
p.Ile261Val
p.Arg262Ala
p.Arg262Thr
p.Arg262Ile
p.Thr263Ala
p.Ile265Ser
p.Ala266Cys
p.Ala266Phe
p.Ala266Leu
p.Phe267Cys
p.Phe267Ala
p.Gly268Val
p.Gly269Val
p.Phe904Cys
p.Arg905Cys
p.Arg905Thr
p.Arg905Ala
p.Ser909Cys
|
D
N
?
D
D
?
D
N
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCB3 |
p.Gly338Ala
|
N
N
?
|
| ABCB4 |
p.Ser908Ala
|
N
D
?
|
The alignment around the queried position:
ABCB11 252
I
G
I
G
A
T
I
L
S
V
S
K
F
T
D
Y
E
L
K
A
Y
A
K
G
V
V
A
D
I
S
S
M
R
T
A
A
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
I
R
K
G
I
V
M
G
F
F
T
F
V
C
331
ABCB1 225
L
V
S
F
T
D
K
L
L
A
Y
A
K
A
A
V
Q
L
N
K
L
E
E
A
R
I
I
K
K
A
304
ABCB1 868
S
G
Q
A
L
K
D
K
K
E
L
E
G
K
I
A
T
E
A
I
E
N
T
V
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
L
R
K
947
ABCB2 398
L
F
L
L
P
K
K
G
K
W
Q
L
L
E
V
Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
P
T
V
R
S
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
Q
E
V
A
Y
A
V
N
S
W
T
T
S
I
477
ABCB3 303
T
I
A
A
E
K
V
Y
N
T
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
A
G
Q
V
R
E
A
V
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
W
R
R
D
L
E
L
Y
L
L
R
V
382
ABCB4 227
L
G
L
S
A
A
V
W
A
K
I
L
S
A
F
S
K
E
L
A
A
Y
K
A
G
V
A
E
E
A
L
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
I
K
K
A
I
S
A
N
S
I
A
F
L
306
ABCB4 867
I
A
V
S
G
I
V
E
M
K
L
L
A
G
N
A
K
R
D
K
K
L
E
A
A
G
K
I
A
T
E
A
I
E
N
I
R
T
V
V
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Q
K
H
Y
G
I
T
S
I
S
946
ABCB5 403
L
A
V
T
G
M
I
E
T
A
A
M
T
G
F
A
N
K
D
K
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
S
C
Y
A
F
S
H
A
482
ABCB6 424
L
T
L
T
I
V
V
T
E
W
R
T
K
F
R
R
A
M
N
T
Q
E
N
A
T
R
A
R
V
D
S
L
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
W
K
S
S
A
S
L
V
L
L
N
Q
T
Q
N
L
503
ABCB7 304
Y
T
A
F
T
V
A
V
T
R
W
R
T
R
F
R
I
E
M
N
K
A
D
N
D
A
G
N
A
A
I
D
S
L
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
L
K
S
T
S
T
L
A
M
L
N
F
G
Q
S
A
383
ABCB8 305
L
M
G
V
G
T
L
M
G
S
G
L
R
K
L
S
R
Q
C
Q
E
Q
I
A
R
A
M
G
V
A
D
E
A
L
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
E
E
L
G
R
G
I
A
L
F
Q
G
L
S
N
I
384
ABCB9 339
I
M
M
V
S
N
I
Y
G
K
Y
Y
K
R
L
S
K
E
V
Q
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
M
K
T
V
R
S
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
R
K
E
A
A
A
Y
M
Y
Y
V
W
G
S
G
L
418
ABCB10 325
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
404
ABCB11 911
L
A
L
S
G
A
T
Q
T
R
M
L
G
F
S
D
A
L
E
M
V
G
Q
T
N
E
A
L
S
N
I
T
V
A
G
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
I
Q
K
A
I
Y
F
C
F
A
F
A
Q
C
990