Mutations at homologous positions to ABCB1 p.Ala354
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCB1 |
p.Ala354Cys
p.Ala354Gly
|
D
D
?
D
D
?
|
ABCB11 |
p.Ala382Gly
|
N
N
?
|
ABCB7 |
p.Glu433Lys
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
ABCB1 |
p.Ser349Cys
p.Ser349Ala
p.Pro350Cys
p.Pro350Ser
p.Ser351Asn
p.Ser351Ala
p.Ser351Cys
p.Ser992Asn
p.Ser992Cys
p.Ser992Ala
p.Ser993Cys
p.Ser993Ala
p.Ser993Arg
p.Phe994Cys
p.Pro996Gln
p.Ala999Thr
p.Ala999Trp
|
D
N
?
N
N
?
D
D
?
N
D
?
N
N
?
N
N
?
N
N
?
D
N
?
D
D
?
D
N
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
N
D
?
D
D
?
|
ABCB11 |
p.Arg387His
p.Tyr1041*
p.Ala1044Pro
|
D
D
?
-
-
?
D
D
?
|
ABCB4 |
p.Pro352Leu
p.Phe357Leu
|
D
D
?
D
D
?
|
ABCB6 |
p.Gln555Lys
|
D
D
D
|
The alignment around the queried position:
ABCB1 316
Y
G
L
V
S
-
Y
I
G
V
I
E
F
A
N
A
R
A
Y
E
I
F
K
I
N
K
S
I
D
S
Y
S
S
G
H
K
P
D
N
-
I
K
G
N
L
393
ABCB1 959
F
G
A
Y
L
V
A
H
-
K
L
M
S
F
E
D
V
V
A
D
Y
K
A
K
I
S
A
H
I
I
M
I
I
K
P
L
I
D
S
Y
S
T
E
G
L
M
N
T
-
E
G
N
V
1036
ABCB2 489
I
G
G
Q
L
V
T
S
-
G
A
V
S
S
G
N
L
V
T
F
V
L
Y
Q
M
Q
F
T
Q
A
E
V
L
L
S
I
Y
P
R
V
Q
K
A
V
G
S
S
E
K
I
F
E
Y
L
D
R
T
P
R
C
P
P
S
G
-
-
L
L
T
P
L
H
-
L
E
G
L
V
Q
564
ABCB3 394
G
L
Q
Q
M
Q
D
-
G
E
L
T
Q
G
S
L
S
F
M
I
Y
Q
E
S
V
G
S
Y
V
Q
T
L
V
Y
I
Y
G
D
M
L
S
N
V
G
A
A
E
K
V
F
S
Y
M
D
R
Q
P
N
L
P
S
P
G
-
-
T
L
A
P
T
T
-
Q
G
V
V
K
469
ABCB4 318
Y
T
L
V
I
S
-
K
E
T
I
G
N
A
M
T
V
F
F
S
I
L
I
G
A
F
V
G
Q
A
A
C
I
D
A
A
N
A
R
G
A
Y
V
F
D
I
I
D
N
N
P
K
I
D
S
F
S
E
R
G
H
K
P
D
S
-
I
K
N
L
395
ABCB4 958
F
G
A
Y
L
I
V
N
-
G
H
M
R
F
R
D
V
I
V
F
A
I
V
F
A
V
A
L
G
H
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
A
H
L
F
M
L
F
E
R
Q
P
L
I
D
S
Y
S
E
E
L
K
P
D
K
-
F
E
G
N
I
T
1035
ABCB5 494
F
G
A
Y
L
I
Q
A
-
G
R
M
T
P
E
G
M
F
I
V
F
T
A
I
A
Y
G
A
A
I
G
E
T
L
V
L
A
P
E
Y
S
K
A
K
S
G
A
A
H
L
F
A
L
L
E
K
K
P
N
I
D
S
R
S
Q
E
G
K
P
D
T
-
C
E
G
N
L
E
571
ABCB6 515
L
C
A
Y
F
V
T
E
-
Q
K
L
Q
V
G
D
Y
V
L
F
G
T
Y
I
I
Q
L
Y
M
P
L
N
W
F
G
T
Y
Y
R
M
I
T
N
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
A
G
P
L
R
F
Q
-
-
K
R
I
E
591
ABCB7 395
L
A
S
Q
G
V
A
-
G
T
L
T
V
G
D
L
M
V
N
G
L
L
F
Q
L
S
L
P
L
N
F
L
G
T
V
Y
R
T
R
Q
A
L
I
D
M
N
T
L
F
T
L
L
K
V
D
T
Q
I
K
D
K
V
M
A
S
P
L
Q
I
T
P
Q
T
A
T
V
A
473
ABCB8 396
I
G
G
S
L
V
A
G
-
Q
Q
L
T
G
G
D
L
M
S
F
L
V
A
S
Q
T
V
Q
R
S
M
A
N
L
S
V
L
F
G
Q
V
V
R
G
L
S
A
G
A
R
V
F
E
Y
M
A
L
N
P
C
I
P
L
S
G
G
C
C
V
P
K
E
Q
-
L
R
G
S
V
T
473
ABCB9 430
Y
G
G
H
L
V
I
S
-
G
Q
M
T
S
G
N
L
I
A
F
I
I
Y
E
F
V
L
G
D
C
M
E
S
V
G
S
V
Y
S
G
L
M
Q
G
V
G
A
A
E
K
V
F
E
F
I
D
R
Q
P
T
M
V
H
D
G
-
-
S
L
A
P
D
H
-
L
E
G
R
V
D
505
ABCB10 416
K
G
G
L
L
M
G
S
-
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
493
ABCB11 343
Y
G
S
T
L
V
L
D
E
G
E
T
P
G
T
L
V
Q
I
F
L
S
V
I
V
G
A
L
N
L
N
A
S
P
C
L
E
F
A
T
G
A
T
S
I
F
E
T
I
D
R
K
P
I
I
D
C
M
S
E
D
Y
K
D
-
I
K
G
E
E
421
ABCB11 1002
Y
Y
I
S
-
E
G
L
H
F
S
Y
V
F
R
V
I
S
A
V
V
L
S
A
A
L
R
A
F
S
Y
T
P
S
A
K
K
I
S
A
A
F
F
Q
L
D
P
P
I
S
V
Y
N
T
A
G
E
K
W
D
N
-
F
Q
G
K
D
1079